АCTIVITY OF LIPID PEROXIDATION PROCESSES IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS AND DIABETES MELLITUS TYPE 2

Abstract

From the pathogenetic point of view, diabetes is associated with a violation of the body's protective systems, including immune and antioxidant defense, as well as the development of oxidative stress.

The aim of the study – to determine the peculiarities of lipid peroxidation processes in blood plasma of patients with chronic generalized periodontitis in combination with type 2 diabetes mellitus.

Materials and Methods. A survey was conducted on 20 practically healthy persons (control group), 36 patients with clinically diagnosed type 2 diabetes mellitus (DM), 32 patients with a confirmed diagnosis of chronic generalized periodontitis (CGP) and 32 patients with combined DM and CGP (group 4).

Results and Discussion. Elevated levels of TBA-AP in the blood plasma of the patients of the group 4 of CGP in the background of type 2 diabetes were observed, they exceeded by 23.4 % the results of the group 2 and by 53.7 % of the group 3 (p <0.05 ). The level of active forms of oxygen, indices of diene and triene conjugates was also highest in patients with type 2 diabetes with a combined pathology of periodontal tissues. The data obtained indicate excessive activation of free-radical processes due to hyperproduction of ROS in all research groups, leading to the development of the pathologies studied.

Conclusions. In patients with chronic generalized periodontitis, the intensification of free radical oxidation processes was established, which was characterized by the growth of ROS and the concentration of diene, triene conjugates, and TBA-active products.