DYNAMICS OF THE POST-INFARCTION HEART REMODELING ON THE DATA OF ECHOCARDIOSCOPY IN THE APPLICATION OF RAMIPRIL AND ZOFENOPRIL

Authors

  • L. Yu. Bidovanets I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2018.3.9754

Keywords:

myocardial infarction, post-infarction cardiac remodeling, arterial pressure, Ramipril, Zofenopril

Abstract

Purpose: to evaluate the dynamics of post-infarction cardiac remodeling using the method of echocardioscopy in patients with myocardial infarction in the acute period, after 14 days of acute coronary event, and in the isolated period – 3 months later, with the use of drugs for the group of angiotensin converting enzyme inhibitors, Ramipril and Zofenopril.

Materials and Methods. We examined 54 patients, who were diagnosed with acute myocardial infarction at the time of hospitalization. We evaluated and compared heart size by the results of echocardiography, blood pressure, heart rate, and dual-dose magnitude.

Results and Discussion. The inclusion of Ramipril and Zofenopril in the complex therapy of patients with AMI is accompanied by almost the same effect on reducing blood pressure and its stable content within the physiological norm within three months of the post-infarction period. The use of Zofenopril in comparison with Ramipril in patients come through AMI after 3 months is accompanied by a significant decrease in heart rate, rate pressure product, end-systolic volume (by 18.7 %), an increase in the ejection fraction (by 16.8 %), which indicates a positive effect of the drug only on the value of blood pressure, but also on the state of the myocardium and its recovery in the post-infarction period.

Conclusions. Inclusion in the complex therapy of patients with acute myocardial infarction of Ramipril and Zofenopril creates prerequisites for reducing the severity of myocardial damage and its recovery in the post-infarction period.

Author Biography

L. Yu. Bidovanets, I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine

Cardiologist of the 2nd category, Doctor-echocardioscopic Ternopil city communal hospital № 2, correspondence postgraduate student of the department of therapy and family medicine of the educational and scientific institute of postgraduate education; I. Horbachevsky Ternopil State Medical University

References

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Published

2019-01-28

How to Cite

Bidovanets, L. Y. (2019). DYNAMICS OF THE POST-INFARCTION HEART REMODELING ON THE DATA OF ECHOCARDIOSCOPY IN THE APPLICATION OF RAMIPRIL AND ZOFENOPRIL. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (3), 5–9. https://doi.org/10.11603/1681-2786.2018.3.9754

Issue

No. 3 (2018)

Section

Health of the population:tendencies and forecasts

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