THE ROLE OF ENDOTHELIAL DYSFUNCTION IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH ANKYLOSING SPONDYLARTHRITIS

Authors

  • S. I. Smiyan I. Horbachevsky Ternopil State Medical University
  • B. O. Koshak I. Horbachevsky Ternopil State Medical University
  • A. V. Bilukha I. Horbachevsky Ternopil State Medical University
  • D. O. Koshak I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/1681-2786.2018.2.9371

Keywords:

ankylosing spondylitis, arterial hypertension, endothelial dysfunction

Abstract

Purpose: to establish the role of endothelial dysfunction in the development of arterial hypertension in patients with ankylosing spondylarthritis.

Materials and Methods. A total of 110 patients with AS were examined with evaluation endothelium-dependent vasodilation (EDVD). All patients received antihypertensive therapy which did not change throughout all study.

Results. It was found that every third patient  suffered from hypertension, endothelial function disorders were detected in 71.8 % of patients. A large cohort of patients showed low levels of HDL and elevated levels of LDL.

At the same time, significant differences in disease activity and functional status were found in the group with hypertension.

Conclusions. We must assume that endothelial dysfunction, which occurs on the background of systemic inflammatory syndrome, is probably the main reason for the development of hypertension in patients with AS.

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Published

2018-09-27

How to Cite

Smiyan, S. I., Koshak, B. O., Bilukha, A. V., & Koshak, D. O. (2018). THE ROLE OF ENDOTHELIAL DYSFUNCTION IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH ANKYLOSING SPONDYLARTHRITIS. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (2). https://doi.org/10.11603/1681-2786.2018.2.9371

Issue

No. 2 (2018)

Section

The science for health care practice

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