EFFECTIVENESS OF THE PATIENTS TREATMENT WITH THE FIRST DIAGNOSED PULMONARY TUBERCULOSIS DEPENDING ON TOXICITY LIVER DAMAGE

Authors

  • O. M. Okusok Ternopil Regional TB Dispensary, Ternopil, Ukraine
  • L. A. Hryshchuk SHEI “Ternopil State Medical University by I.Ya. Horbachevsky Ministry of Health of Ukraine”, Ternopil, Ukraine
  • Y. M. Maliy Ternopil Regional TB Dispensary, Ternopil, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2017.2.8103

Keywords:

first diagnosed pulmonary tuberculosis, toxic liver damage, the effectiveness of treatment.

Abstract

Purpose: to analyze the effectiveness of the treatment of patients with newly diagnosed pulmonary tuberculosis depending on toxic liver damage.

Materials and methods. It was investigated 57 cases hospital treatment of patients with first diagnosed pulmonary tuberculosis. Patients were divided into 2 groups according to the occurrence of toxic liver lesions during treatment. Group 1 (29 patients) –during treatment  toxic liver damage were found, group 2 – (28 patients) – toxic liver damage during treatment not observed.

Results. It is established that the maximum number of toxic complications of the liver is observed on 2 (48.3%) month of hospital treatment. In the group of patients without liver toxicity during therapy cure rate efficiency  better than in the first group, in particular the cessation of bacterial excretion was noted in 88.0% , in the 1-st group – 75.0%, the closing of destruction cavities respectively in 77,8% against 62.5%.

Conclusions. Toxic liver damage affects the efficiency of hospital treatment of patients with pulmonary tuberculosis.

References

Balasanyants, G.S. & Sukhanov, D.S. (2011) Pobochnyye deystviya protivotuberkuleznykh preparatov i metody ikh ustraneniya [Side effects of antituberculosis drugs and methods for their elimination]. Sankt-Peterburg: Taktik-Studio [in Russian].

Wolf, S.B. (2016) Nezhelatel'nyye pobochnyye reaktsii na khimioterapiyu tuberkuleza [Undesirable side reactions to chemotherapy for tuberculosis]. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta – Journal of the Grodno State Medical University, 3, 141-146 [in Russian].

Zozuliak, V.I., Zozuliak, N.V. & Pylypenko I.I. (2015) Osoblyvosti porushennya biokhimichnykh pokaznykiv funktsiyi pechinky u khvorykh na destruktyvnyy tuberkul’oz lehen’ ta yikhnya korektsiya [Features abuse biochemical parameters of liver function in patients with destructive pulmonary tuberculosis and their correction]. Tuberkul’oz, lehenevi khvoroby, VIL-infektsiya – Tuberculosis, pulmonary disease, HIV infection, 2, 85-89 [in Ukrainian].

Feschenko, Y.I., Cherenko, S.A., Matveeva O.V., Yaychenya, V.P. & Logvina, I.A. (2014). Pobichni reaktsiyi protytuberkul’oznykh preparativ u protsesi otsinky naslidkiv likuvannya khvorykh na tuberkul’oz. [Side effects of TB drugs in the assessment of the effects of treatment for tuberculosis]. Tuberkul’oz, lehenevi khvoroby, VIL-infektsiya – Tuberculosis, pulmonary diseases, HIV, 4, 13-20. [in Ukrainian]..

Todoriko, L.D. & Sem'yaniv, I.O. (2015) Struktura suputn’oyi patolohiyi hepatobiliarnoyi systemy pry vpershe diahnostovanomu tuberkul’ozi lehen’ zalezhno vid spektra chutlyvosti [Structure comorbidity hepatobiliary system with newly diagnosed pulmonary tuberculosis based on spectral sensitivity]. Aktual’na infektolohiya Current infectiology, 4, 51-54 [in Ukrainian]..

Tuberkul’oz v Ukrayini: Analitychno-statystychnyy dovidnyk [Tuberculosis in Ukraine: analytical and statistical references]. (2016) Kyyiv [in Ukrainian].

Unifikovanyy klinichnyy protokol pervynnoyi, vtorynnoyi (spetsializovanoyi) ta tretynnoyi (vysokospetsializovanoyi) medychnoyi dopomohy. Tuberkul’oz u doroslykh [Unified clinical protocols of primary, secondary (specialized) and tertiary (highly specialized) medical care. Tuberculosis in Adults]. (2014). Nakaz MOZ Ukrayiny № 620 vid 04.09.2014 r – Prescript MOH Ukraine number 620 of 09/04/2014. [in Ukrainian].

Vidyasagar Ramappa, Guruprasad P. Aithal Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management . Clinical and Experimental Hepatology . 2013;3 (1): 37–49.

Yi-Shin Huang. Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury. Expert Opin Drug MetabToxicol. 2007;3(1):1-8.

Published

2017-09-26

How to Cite

Okusok, O. M., Hryshchuk, L. A., & Maliy, Y. M. (2017). EFFECTIVENESS OF THE PATIENTS TREATMENT WITH THE FIRST DIAGNOSED PULMONARY TUBERCULOSIS DEPENDING ON TOXICITY LIVER DAMAGE. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (2). https://doi.org/10.11603/1681-2786.2017.2.8103

Issue

Section

Organization of medical care