EFFECT OF KRIOKSENODERM ON INDICATORS OF LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM UNDER ALLERGIC DERMATITIS
DOI:
https://doi.org/10.11603/1681-2786.2014.2.3384Abstract
Purpose: investigate the dynamics of the content of lipid peroxidation products and activity of catalase and ceruloplasmin in plasma and liver homogenates of allergic dermatitis on the condition of oral krioksenoderm.
Materials and methods. Experimental allergic contact dermatitis as a model of delayed-type reactions reproduced in guinea pigs. Allergen was used 2.4 dunytrohlorbenzol (DNHB) in a 5% alcohol-acetone solution. Fireplace sensitization formed on the back of the animal area (9 cm2), which previously was removed fur cover.
Results. After intragastric introduction of krioksenoderm is observed decrease in animals with allergic contact dermatitis content of lipid hydroperoxides and malondialdehyde (MDA). The most significant reduction of MDA in blood and liver, led of intragastric introduction of ksenoshkiry for 26 day of experiment. The activity of catalase and ceruloplasmin content were subjected improvement after a single intragastric administration.
Conclusion. Corrective action found krioksenoderm on the processes of lipid peroxidation and activity of antioxidant enzymes, suggesting the possibility of its use for therapeutic purposes.
KEY WORDS: allergic dermatitis, antioxidants, krioksenoderm.Downloads
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