MOLECULAR AND GENETIC VARIANTS OF THE VITAMIN D RECEPTOR GENE AT CHILDREN OF DIFFERENT REGIONS OF THE CARPATHIANS AT PRESENCE OF TEETH ANOMALIES AND DEFORMATIONS
DOI:
https://doi.org/10.11603/1681-2786.2014.2.3383Abstract
Purpose: To determine features of alleles distribution of vitamin D receptor gene at children living in different anthropogenous conditions.
Materials and methods. Epidemiological survey of 496 children from 6 to 15-years old, living in different regions of the Carpathians has been carried out. Investigated features of alleles distribution of vitamin D receptor gene in whey of blood, which took away in the morning on an empty stomach. Definition Bsml, Apal, Tagl polimorphism of vitamin D receptor gene (VDR) was performed by PCR with subsequent restriction analysis.
Results. It is established that presence of В-, t-, a-, A-alleles VDR gene at children with dentition anomalies and deformities of plain and foothill zones and B-and A-alleles in patients with dentition anomalies and deformities of mountain zone may act as a molecular and genetic markers of risk of teeth anomalies.
Conclusions. The revealed features can be applied at predicting of occurrence of pathological dentition apparatus conditions in children of the given region.
Key words: children, dentition anomalies and deformities, molecular and genetic marker of risk, vitamin D receptor.Downloads
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