ANALYSIS OF RISK FACTORS FOR OBSTETRIC AND PERINATAL COMPLICATIONS PATHOGENETICALLY LINKED TO GESTATIONAL DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1681-2786.2025.4.15907Keywords:
gestational diabetes mellitus; metabolic disorders; quality of life; angiogenesis factors; placental dysfunction; maternal complications; neonatal outcomes.Abstract
Purpose: To analyze the prevalence of gestational diabetes mellitus among pregnant women and evaluate its impact on maternal and neonatal quality of life. Materials and Methods. A comprehensive review of contemporary scientific literature from the past ten years was conducted using databases such as PubMed, Scopus, and Web of Science. The selection included studies examining epidemiological data, metabolic and angiogenic markers, and clinical outcomes associated with gestational diabetes mellitus. Comparative and analytical methods were applied to summarize current findings and identify key determinants influencing disease development and pregnancy outcomes. Results. The analysis revealed a global increase in the prevalence of gestational diabetes mellitus, ranging from 2% to 38% depending on population and diagnostic criteria. GDM was shown to significantly contribute to maternal complications such as preeclampsia, hypertension, and metabolic syndrome, as well as adverse neonatal outcomes including macrosomia, hypoglycemia, and long-term metabolic disorders. Furthermore, alterations in angiogenic balance were identified as an important pathogenetic link between GDM and placental dysfunction. Early detection and preventive management strategies were found to improve pregnancy outcomes and reduce perinatal risks. Conclusion: Gestational diabetes mellitus represents a major metabolic and vascular challenge in pregnancy, underscoring the need for early diagnostic screening and targeted interventions to improve maternal and neonatal health outcomes.
References
McIntyre H. D., Catalano P., Zhang C., Desoye G., Mathiesen E. R., Damm P. Gestational diabetes mellitus. Nature Reviews Disease Primers. 2019. No 5. P. 47. DOI: https://doi.org/10.1038/s41572-019-0098-8
Plows J. F., Stanley J. L., Baker P. N., Reynolds C. M., Vickers M. H. The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences. 2018. No 19(11). DOI: https://doi.org/10.3390/ijms19113342
American Diabetes Association. Standards of Care in Diabetes–2024. Diabetes Care. 2024. No 47(Suppl. 1). P. S1–S167. DOI: https://doi.org/10.2337/dc24-SDIS
American College of Obstetricians and Gynecologists (ACOG). Gestational Diabetes Mellitus: ACOG Practice Bulletin No. 190. Obstetrics & Gynecology. 2018. No 131(2). P. e49–e64. DOI: https://doi.org/10.1097/AOG.0000000000002501
Chaiworapongsa T., Romero R., Espinoza J. Evidence supporting a role for angiogenic/anti-angiogenic factors in the pathophysiology of gestational diabetes mellitus. American Journal of Obstetrics and Gynecology. 2010. No 203(5). P. 446.e1–446.e12.
Weissgerber T. L., Mudd L. M. Preeclampsia and diabetes. Current Diabetes Reports. 2015. No 15(3). P. 9. DOI: https://doi.org/10.1007/s11892-015-0579-4
Нормальна вагітність: галузевий стандарт медичної допомоги : Наказ МОЗ України №1437 від 09.08.2022. Київ, 2022.
Rizov M., Andreeva P., Dimova I. Acquired placental deficiency – A new insight into the pathogenesis of gestational diabetes mellitus. Journal of Maternal-Fetal & Neonatal Medicine. 2017. No 30(17). P. 2043–2049.
Maynard S.E., Karumanchi S.A. Angiogenic factors and preeclampsia. Seminars in Nephrology. 2011. No 31(1). P. 33–46. DOI: https://doi.org/10.1016/j.semnephrol.2010.10.004
Zeisler H., Llurba E., Chantraine F. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia. New England Journal of Medicine. 2016. No 374. P. 13–22. DOI: https://doi.org/10.1056/NEJMoa1414838
Al-Ofi E., Alrafiah A., Maidi S., Almaghrabi S., Hakami N. Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes. International Journal of General Medicine. 2021. No 13(14). P. 3367–3375. DOI: https://doi.org/10.2147/IJGM.S316670
Bashir M., Ibrahim I., Eltaher F. et al. Screening pregnant women in a high-risk population with WHO-2013 or NICE diagnostic criteria does not affect the prevalence of gestational diabetes. Scientific Reports. 2021. No 11. P. 5604. DOI: https://doi.org/10.1038/s41598-021-84918-y
Betz C., Lenard A., Belting H.G., Affolter M. Cell behaviors and dynamics during angiogenesis. Development. 2016. No 143(13). P. 2249–2260. DOI: https://doi.org/10.1242/dev.135616
Bilyi Ye.Ye., Borzenko I., Tertyshnyk D. Early diagnosis of placental dysfunction in pregnant women with extragenital pathology. Proccedings of International Scientisic Congress “ISIC-2020”. 2020. P. 169–173.
Bogdanet, D., O’Shea, P., Lyons, C., Shafat, A., Dunne, F. The Oral Glucose Tolerance Test–Is It Time for a Change. A Literature Review with an Emphasis on Pregnancy. Journal of Clinical Medidcine. 2020. No 9. P. 3451. DOI: https://doi.org/10.3390/jcm9113451
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