THE IMPACT OF ENDOMETRIOSIS ON THE HORMONAL SYSTEM OF WOMEN: CLINICAL CONSEQUENCES AND PROSPECTS OF TREATMENT
DOI:
https://doi.org/10.11603/1681-2786.2024.2.14796Keywords:
endometriosis, infertility, assisted reproductive technologies, in vitro fertilization, female hormonal systemAbstract
Purpose: to investigate the problem and impact of endometriosis on the hormonal system of women in modern scientific literature.
Materials and Methods. 25 sources of modern foreign scientific literature were analyzed. For this, the bibliosemantic method was used.
Results. Endometriosis is a complex disease that affects various aspects of the hormonal regulation of the female body. This literature review focuses on the following aspects:
- Hormone levels: In endometriosis, there is an imbalance of hormones, in particular, a decrease in testosterone levels and an increase in the activity of gonadotropins.
- Effect on the ovaries: women with endometriosis often have changes in ovarian function, such as accelerated depletion of the ovarian reserve and a decrease in preovulatory follicles.
- Apoptosis of follicles: elevation of proapoptotic factors in follicular fluid promotes follicular atresia in women with endometriosis.
- Relationship to Clinical Manifestations: Studies show that hormonal changes associated with endometriosis may be associated with clinical manifestations such as infertility and pain.
These results allow a better understanding of the mechanisms of interaction of endometriosis with the hormonal system and possible ways of influencing this disease through the regulation of hormonal balance.
Conclusions. The obtained results allow a better understanding of the mechanisms of interaction between endometriosis and the hormonal system, as well as potential ways to influence this condition through regulation of hormonal balance. Therefore, further research is aimed at understanding the deeper molecular mechanisms of interaction between endometriosis and the hormonal system, which will allow to develop new effective treatment strategies and improve the clinical prognosis for patients with this disease.
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