INFLUENCE OF INTESTINAL MICROBIOTA ON THE DEVELOPMENT AND COURSE OF PARKINSONʼS DISEASE

Authors

  • O. O. Kulyanda I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • R. I. Zaremba I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • O. S. Bilovus I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • O. V. Denefil I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • Ye. B. Dmukhalska I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2023.4.14434

Keywords:

intestinal microbiota, Parkinsonʼs disease, dysbiosis

Abstract

Purpose: to evaluate the influence of dysbiosis on the development and severity of the course of Parkinson's disease.

Materials and Methods. A comparative and systematic analysis of literature sources from the PubMed database, which relate to the importance of intestinal microbiota in the pathogenesis of Parkinson's disease, was conducted.

Results. One of the pathogenetic links in the development of Parkinsonʼs disease (PD) is dysbiosis of the intestinal microflora with a decrease in the diversity of microorganisms and changes in the metabolism of the intestinal microbiota; damage to the intestinal mucosa and increase its permeability; activation of the immune response with the consequences of systemic and neurogenic inflammation; disruption of gut-brain signaling mechanisms, including neural, endocrine, and metabolic pathways. Specific changes in the composition and metabolic activity of the intestinal microbiota can be used as biomarkers or additional criteria for the prevention of Parkinsonʼs disease. Therapeutic methods aimed at correcting the composition and metabolic activity of the intestinal microbiota, such as fecal transplantation, the use of psychobiotics and neuroactive derivatives of probiotic bacteria, bring positive results.

Conclusions. Research into the mechanisms of influence of microorganisms and their products on the functional activity of the central nervous system requires further development. It is important to consider the intestinal microbiome as a key object in the diagnosis and therapy of neuropsychiatric disorders and diseases. The approach aimed at correcting the composition and functional activity of the intestinal microbiota is a promising strategy for increasing the effectiveness of the treatment of psychoneurological pathologies. Using a microbiome approach allows for earlier detection of these diseases and predicting their course.

Author Biographies

O. O. Kulyanda, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

PhD (Medicine), Associate Professor, Associate Professor of the Department of Pathological Physiology, I. Horbachevsky Ternopil National Medical University

R. I. Zaremba, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

is a 4th-year student specialty «Medicine» of the I. Horbachevsky Ternopil National Medical University

O. S. Bilovus, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

is a 4th-year student specialty «Medicine» of the I. Horbachevsky Ternopil National Medical University

O. V. Denefil, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DM (Medicine), Professor, Head of the Department of pathological physiology, I. Horbachevsky Ternopil National Medical University

Ye. B. Dmukhalska, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

PhD (Biological Sciences), Associate Professor, Associate Professor of the Department of General Chemistry, I. Horbachevsky Ternopil National Medical University

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Published

2024-02-13

How to Cite

Kulyanda, O. O., Zaremba, R. I., Bilovus, O. S., Denefil, O. V., & Dmukhalska, Y. B. (2024). INFLUENCE OF INTESTINAL MICROBIOTA ON THE DEVELOPMENT AND COURSE OF PARKINSONʼS DISEASE . Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (4), 98–104. https://doi.org/10.11603/1681-2786.2023.4.14434

Issue

No. 4 (2023)

Section

The review of the scientific literature

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