RISK FACTORS AND PREVENTION OF GESTATIONAL DIABETES
DOI:
https://doi.org/10.11603/1681-2786.2022.3.13440Keywords:
gestational diabetes, risk factors, pregnancy, prevention, meta-analysisAbstract
Purpose: to evaluate the main risk factors for the development of gestational diabetes mellitus (GDM) and directions for its prevention.
Materials and Methods. An analysis of scientific sources of information (PubMed electronic database) regarding the medical and social problem of GCD was carried out. Bibliosemantic, analytical research methods were used.
Results. GDM causes short-term and long-term negative health consequences for both women and their children, such as pre-eclampsia during pregnancy, significantly increased risk of type 2 diabetes, cardiovascular disease, macrosomia, autism, childhood obesity, impaired glucose tolerance and vascular disorders. Epidemiological studies indicate genetic (heavy family history), environmental (exposure to perfluorooctanoic acid), behavioral (high body weight or obesity, smoking) risk factors for the development of HCD. Therefore, the correction of the latter, namely the popularization of the Mediterranean diet in women before and during pregnancy, the use of dosed physical activity contribute to the prevention of GDM. Among all the studies published to date of physical activity interventions with dietary modification for the prevention of GDM, the results of most studies indicate a beneficial effect, but only if the intervention is started early in the first trimester.
Conclusions. GDM not only increases the risk of complications during pregnancy for the mother and fetus, but also significantly increases the risk of type 2 diabetes, metabolic syndrome, and cardiovascular disease after pregnancy. That is why it is so important to take measures to correct the above-described risk factors for the development of HCD for adequate prevention of this disease.
References
Kwak, S.H., Kim, S.H., Cho, Y.M., Go, M.J., Cho, Y.S., Choi, S.H., … Park, K.S. (2012). A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes, 61, 531-541.
Bowers, K., Tobias, D.K., Yeung, E., Hu, F.B., & Zhang, C. (2012). A prospective study of prepregnancy dietary fat intake and risk of gestational diabetes. Am. J. Clin. Nutr., 95, 446-453.
Bowers, K., Yeung, E., Williams, M.A., Qi, L., Tobias, D.K., Hu, F.B., & Zhang, C. (2011). A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care, 34, 1557-1563.
Zhang, C., Sundaram, R., Maisog, J., Calafat, A.M., Barr, D.B., & Buck Louis, G.M. (2015). A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes. Fertil. Steril., 103, 184-189.
Zhang, C., Tobias, D.K., Chavarro, J.E., Bao, W., Wang, D., Ley, S.H., & Hu, F.B. (2014). Adherence to healthy lifestyle and risk of gestational diabetes mellitus: prospective cohort study. BMJ, 349, g5450.
Dodd, J.M., Turnbull, D., McPhee, A.J., Deussen, A.R., Grivell, R.M., Yelland, L.N., ... Robinson, J.S. (2014). Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. BMJ, 348, g1285.
Xiang, A.H., Wang, X., Martinez, M.P., Walthall, J.C., Curry, E.S., Page, K., … Getahun, D. (2015). Association of maternal diabetes with autism in offspring. JAMA, 313, 1425-1434.
Loy, S.L., Lek, N., Yap, F., Soh, S.E., Padmapriya, N., Tan, K.H., ... Chan, J.K. (2015). Association of maternal vitamin d status with glucose tolerance and caesarean section in a multiethnic Asian cohort: the growing up in Singapore towards healthy outcomes study. PLoS One, 10, e0142239.
Poston, L., Bell, R., Croker, H., Flynn, A.C., Godfrey K.M., Goff L., ... Briley, A-L. (2015). Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol., 3, 767-777.
Sanabria-Martinez, G., Garcia-Hermoso, A., Poyatos-Leon, R., Alvarez-Bueno, C., Sanchez-Lopez, M., & Martinez-Vizcaino, V. (2015). Effectiveness of physical activity interventions on preventing gestational diabetes mellitus and excessive maternal weight gain: a meta-analysis. BJOG, 122, 1167-1174.
Cordero, Y., Mottola, M.F., Vargas, J., Blanco, M., & Barakat, R. (2015). Exercise is associated with a reduction in gestational diabetes mellitus. Med. Sci. Sports Exerc., 47, 1328-1333.
Zhou, S.J., Yelland, L., McPhee, A.J., Quinlivan, J., Gibson, R.A., & Makrides, M. (2012). Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. Am. J. Clin. Nutr., 95, 1378-1384.
Zhang, C., Bao, W., Rong, Y., Yang H., Bowers, K., Yeung, E, & Kiely, M. (2013). Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum. Reprod. Update, 19, 376-390.
Koivusalo, S.B., Rono, K., Klemetti, M.M., Roine, R.P., Lindström, J., Erkkola, M., ... Stach-Lempinen, B. (2016). Gestational diabetes mellitus can be prevented by lifestyle intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): a randomized controlled trial. Diabetes Care, 39, 24-30.
Petrella, E., Malavolti, M., Bertarini, V., Pignatti, L., Neri, I., Battistini, N.C, & Facchinetti, F. (2014). Gestational weight gain in overweight and obese women enrolled in a healthy lifestyle and eating habits program. J. Matern. Fetal Neonatal Med., 27, 1348-1352.
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., ... Wiersinga, W. (2011). Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid, 21, 1081-1125.
Harreiter, J., Dovjak, G., & Kautzky-Willer, A. (2014). Gestational Diabetes Mellitus and Cardiovascular Risk after Pregnancy. Women’s Health, 10, 91-108.
De Groot, L., Abalovich, M., Alexander, E.K., Amino N., Barbour, L., Cobin, R.H., ... Sullivan, S. (2012). Management of thyroid dysfunction during pregnancy and postpartum: An endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab., 97, 2543-2565.
Fraser, A., Almqvist, C., Larsson, H., Langstrom, N., & Lawlor, D.A. (2014). Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families. Diabetologia, 57, 102-109.
D’Anna, R., Di Benedetto, A., Scilipoti, A., Santamaria, A., Interdonato, M.L., Petrella, E., ... Facchinetti, F. (2015). Myo-inositol supplementation for prevention of gestational diabetes in obese pregnant women: a randomized controlled trial. Obstet. Gynecol., 126, 310-315.
Bao, W., Michels, K.B., Tobias, D.K., Li, S., Chavarro, J.E., Gaskins, A.J., ... Zhang, C. (2016). Parental smoking during pregnancy and the risk of gestational diabetes in the daughter. Int. J. Epidemiol., 45, 160-169.
Phelan, S. (2010). Pregnancy: a “teachable moment” for weight control and obesity prevention. Am. J. Obstet. Gynecol., 202, e131-e138.
Tobias, D.K., Zhang, C., van Dam, R.M., Bowers, K., & Hu, F.B. (2011). Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis. Diabetes Care, 34, 223-229.
Russo, L.M., Nobles, C., Ertel, K.A., Chasan-Taber, L., & Whitcomb, B.W. (2015). Physical activity interventions in pregnancy and risk of gestational diabetes mellitus: a systematic review and meta-analysis. Obstet. Gynecol., 125, 576-582.
Tobias, D.K., Zhang, C., Chavarro, J., Bowers, K., Rich-Edwards, J., Rosner, B., ... Hu, F.B. (2012). Prepregnancy adherence to dietary patterns and lower risk of gestational diabetes mellitus. Am. J. Clin. Nutr., 96, 289-295.
Bao, W., Bowers, K., Tobias, D.K., Hu, F.B., & Zhang, C. (2013). Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetes Care, 36, 2001-2008.
Bao, W., Tobias, D.K., Olsen, S.F., & Zhang, C. (2014). Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetologia, 57, 2485-2491.
Bao, W., Bowers, K., Tobias, D.K., Olsen, S.F., Chavarro, J., Vaag, A., ... Zhang, C. (2014). Prepregnancy low-carbohydrate dietary pattern and risk of gestational diabetes mellitus: a prospective cohort study. Am. J. Clin. Nutr., 99, 1378-1384.
Chen, L., Hu, F.B., Yeung, E., Willett, W., & Zhang, C. (2009). Prospective study of pre-gravid sugar-sweetened beverage consumption and the risk of gestational diabetes mellitus. Diabetes Care, 32, 2236-2241.
Rayanagoudar, G., Hashi, A.A., Zamora, J., Khan, K.S., Hitman, G.A., & Thangaratinam, S. (2016). Quantification of the type 2 diabetes risk in women with gestational diabetes: a systematic review and meta-analysis of 95,750 women. Diabetologia, 59, 1403-1411.
Maratou, E., Hadjidakis, D.J., Kollias, A., Tsegka, K., Peppa M., Alevizaki M., ... Dimitriadis, G. (2009). Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur. J. Endocrinol., 160, 785-790.
Sullivan, S.D., Umans, J.G., & Ratner, R. (2012). Gestational diabetes: Implications for cardiovascular health. Curr. Diab. Rep., 12, 43-52.
Ruiz, J.R., Perales, M., Pelaez, M., Lopez, C., Lucia, A., & Barakat, R. (2013). Supervised exercise-based intervention to prevent excessive gestational weight gain: a randomized controlled trial. Mayo Clin. Proc., 88, 1388-1397.
Jing, W., Huang, Y., Liu, X., Luo, B., Yang, Y., & Liao, S. (2015). The effect of a personalized intervention on weight gain and physical activity among pregnant women in China. Int. J. Gynaecol. Obstet., 129, 138-141.
Tomic, V., Sporis, G., Tomic, J., Milanovic, Z., Zigmundovac-Klaic, D., & Pantelic, S. (2013). The effect of maternal exercise during pregnancy on abnormal fetal growth. Croat. Med. J., 54, 362-368.
Springer, D., Jiskra, J., Limanova, Z., Zima, T., & Potlukova, E. (2017). Thyroid in pregnancy: From physiology to screening. Crit. Rev. Clin. Lab. Sci., 54, 102-116.
Garduño-Garcia, J.D.J., Alvirde-Garcia, U., López-Carrasco, G., Mendoza, M.E.P., Mehta, R., Arellano-Campos, O., ... Aguilar-Salinas, C.A. (2010). TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur. J. Endocrinol., 163, 273-278.
Velasco, I., & Taylor, P. (2018). Identifying and treating subclinical thyroid dysfunction in pregnancy: emerging controversies. Eur. J. Endocrinol., 178, D1-D12.
Zhang, C., & Ning, Y. (2011). Effect of dietary and lifestyle factors on the risk of gestational diabetes: review of epidemiologic evidence. Am. J. Clin. Nutr., 94, 1975S-1979S.
Zhu, Y., & Zhang, C. (2016). Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective. Curr. Diab. Rep., 16, 7.
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