EVALUATION OF CHANGES IN PARAMETERS OF MENSTRUAL FUNCTION AGAINST THE BACKGROUND OF COVID-19 AND THE IMPACT ON REPRODUCTIVE FUNCTION
(literature review)
DOI:
https://doi.org/10.11603/1681-2786.2022.4.13339Keywords:
menstrual cycle, melatonin, COVID-19, ACE2, sleep disorders, hormones, reproductive function, infertilityAbstract
Purpose: to conduct an analysis of modern literature on changes in the parameters of menstrual function against the background of COVID-19 infection and its subsequent impact on reproductive function
Materials and Methods. Bibliosemantic and analytical methods of modern literature analysis were used to write this literature review.
Results. The analysis of literature data proved that the selected research topic is relevant at the moment, as the impact of COVID-19 on women’s reproductive function has been confirmed. The pathogenesis consists in the penetration of the SARS CoV-2 virus into the organs of the female reproductive system with the help of receptors of angiotensin-converting enzyme 2 (ACE2), which is expressed on the cells of these organs, and the occurrence of changes in the parameters of the menstrual cycle and hormones of the reproductive system. Also, the role of melatonin as a regulator of circadian sleep rhythms that is also responsible for the functioning of the menstrual cycle has been established. Since, according to the collected data, COVID-19 contributes to the occurrence of menstrual cycle disorders, as well as changes in sleep processes, menstrual cycle disorders may be directly or indirectly caused by deviations in melatonin concentrations in the body. The result is negative consequences for female reproductive function.
Conclusions. COVID-19 causes disruption of the menstrual cycle, which is reflected in the female reproductive system. Given the prevalence of this problem, it is relevant and requires in-depth study in order to investigate further consequences on the female body.
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