THE INFLUENCE OF CO-MORBID CONDITIONS ON THE SURVIVAL OF MALE PATIENTS WITH LARYNGEAL CANCER: RESULTS OF TEN YEARS OBSERVATION
DOI:
https://doi.org/10.11603/1681-2786.2021.2.12127Keywords:
laryngeal cancer, co-morbidity index, men, age, Kaplan-Mayer survival analysisAbstract
Purpose. To study the effect of co-morbid diseases on the survival of men with laryngeal cancer depending on age.
Materials and Methods. Epidemiological, medical-statistical and analytical methods are used in the work. The databases “Hospital Cancer Register” and the database of the Ternopil Regional Statistical Office on the population and mortality in the region for 2009–2019 were analyzed. Based on the calculated index of co-morbid conditions according to Charlson (1987) and the data of the official Hospital documentation “Report form № 20” the survival of patients with laryngeal cancer who were hospitalized in Ternopil Regional Clinical Oncology Dispensary was analyses.
Results. The survival function of patients with laryngeal cancer for the period 2009-2019 was analyzed by the method of multiple assessments (according to Kaplan-Mayer). It was found that the median survival in the general group of patients with laryngeal cancer was 914 days from the date of diagnosis (laryngeal cancer), and the 25th and 75th percentile of survival were 365 and 1986 days, respectively.
In the group of patients with laryngeal cancer in men younger than 60 years, the median survival was 580 days, and in the group older than 60 years – 578 days (without significant difference). However, a comparative statistical analysis of Cox’s F-test survival indicated a significant statistical difference in the survival of laryngeal cancer patients over 60 years of age and with a high co-morbidity index compared with the group of men less than 60 years of age and with a low co-morbidity index.
Conclusions. The cumulative survival rate of men with laryngeal cancer depends on the concomitant pathology detected at the time of diagnosis. The survival time of patients with laryngeal cancer in men over 60 years of age and a high co-morbidity index is shorter compared to the group of men less than 60 years and a low co-morbidity index. Male patients with laryngeal cancer older than 60 years and a high co-morbidity index require the elaborate of special treatment tactics, taking into account the identified co-morbid pathology.
References
Galaychuk, I.Y., Zhulkevych, I.V., Smiyan, S.I., Nykolyuk, V.D., & Komorovsky, R.R. (2019). Boreliozna limfadenopatiia u praktytsi onkoloha (klinichni sposterezhennia) [Borrelious lymphadenopathy in oncology practice (clinical observations)]. Onkolohiia – Oncology, 21, 3 [in Ukrainian]. DOI: 10.32471/oncology.2663-7928.t-21-3-2019-g.7896. Retrieved from: https://www.oncology.kiev.ua/article/7896/boreliozna-limfadenopatiya-u-prakticionkologa-klinichni-sposterezhennya.
Zhulkevych, I.V., & Halaichuk, I.Yo. (2019). Pervynna leheneva limfoma z bronkhoasotsiyovanoi limfoidnoi tkanyny (klinichne sposterezhenna) [Primary pulmonary lymphoma from bronchus-associated lymphoid tissue (clinical observation)]. Pathologia, 16 (2), 293-298 [in Ukrainian].
Fedorenko, Z.P., Hulak, L.O., Mykhailovych, Yu.Y., Horokh, Ye.L., Ryzhov, A.Yu., Sumkina, O.V., & Kutsenko, L. (2018). Rak v Ukraini, 2016–2017. Zakhvoriuvanist, smertnist, pokaznyky diialnosti onkolohichnoi sluzhby [Cancer in Ukraine, 2016–2017. Incidence, mortality, indicators for activities of the oncological service]. Biuleten Natsionalnoho kantser-reiestru Ukrainy – Bulletin of the National Cancer Registry of Ukraine, 19. Retrieved from: www.ncru.inf.ua/publications/BULL_19/index.htm. [in Ukrainian].
Fedorenko, Z., Michailovich, Yu., Goulak, L., Gorokh, Ye., Ryzhov, A., Soumkina, O., & Koutsenko, L. (2021). Rak v Ukraini, 2019–2020. Zakhvoriuvanist, smertnist, pokaznyky diialnosti onkolohichnoi sluzhby [Cancer in Ukraine, 2019–2020. Incidence, mortality, indicators for activities of the oncological service]. Biuleten Natsionalnoho kantser-reiestru Ukrainy – Bulletin of the National Cancer Registry of Ukraine, 22. Retrieved from: www.ncru.inf.ua/publications/BULL_22/index.htm. [in Ukrainian].
Mulcahy, C.F., Mohamed, A.S.R., Kanwar, A., Hutcheson, K.A., Ghosh, A., Vock, D., …, & Fuller, C.D. (2018). Age‐adjusted comorbidity and survival in locally advanced laryngeal cancer. Head Neck, 40 (9), 2060-2069. DOI: https://doi.org/10.1002/hed.25200.
Steuer, C.E., El-Deiry, M., Parks, J.R., Higgins, K.A., & Saba, N.F. (2017). An update on larynx cancer. CA Cancer. J. Clin., 67 (1), 31-50. DOI: 10.3322/caac.21386.
(2021). Cancer Facts & Figures 2021. Atlanta: American Cancer Society.
Hu, M., Ampil, F., Clark, C., Sonavane, K., Caldito, G., & Nathan, C.A. (2012). Comorbid predictors of poor response to chemoradiotherapy for laryngeal squamous cell carcinoma. Laryngoscope, 122 (3), 565-571. DOI: 10.1002/lary.22489.
Rudolph, E., Dyckhoff, G., Becher, H., Dietz, A., & Ramroth, H. (2011). Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis. Eur. Arch. Otorhinolaryngol., 268 (2), 165-179. DOI: 10.1007/s00405-010-1395-8.
Fararouei, M., Daneshi, N., Mohammadianpanah, Μ., Reza Tabatabaei, H., Zare-Bandamiri, M., & Dianatinasab, M. (2017). Factors predicting survival in patients with early stage laryngeal cancer: A cohort study between 2000 to 2015. J. BUON, 22 (4), 996-1003.
Nahavandipour, A., Jakobsen, K.K., Grønhøj, C., Hebbelstrup Jensen, D., Kim Schmidt Karnov, K., Klitmøller Agander, T., ..., & von Buchwald, C. (2019). Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014. Acta Oncol., 58 (7), 977-982. DOI: 10.1080/0284186X.2019.1572923.
Morshed, K., Szymański, M., Siwiec, H., & Gołabek, W. (2008). Laryngeal cancer in farmers from Lublin region of Poland. Ann. Agric. Environ. Med., 15 (1), 13-19.
Igissinov, N., Zatoskikh, V., Moore, M.A., Igissinov, S., Aldiyarova, G., Tokmurziyeva, G., …, & Sarsenova S. (2013). Laryngeal cancer in Kazakhstan - ethnic, age and gender differences over time. Asian Pac. J. Cancer Prev., 14 (11), 7033-7038. DOI: 10.7314/apjcp.2013.14.11.7033.
Zhang, S.S., Xia, Q.M., Zheng, R.S., & Chen, W.Q. (2015). Laryngeal cancer incidence and mortality in China, 2010. J. Cancer. Res. Ther., 11 (Suppl 2), C143-148. DOI: 10.4103/0973-1482.168175.
Chatenoud, L., Garavello, W., Pagan, E., Bertuccio, P., Gallus, S., La Vecchia, C., …, & Bosetti, C. (2016). Laryngeal cancer mortality trends in European countries. Int. J. Cancer, 138 (4), 833-842. DOI: 10.1002/ijc.29833.
Jones, T.M., De, M., Foran, B., Harrington, K., & Mortimore, S. (2016). Laryngeal cancer: United Kingdom National Multidisciplinary guidelines. J. Laryngol. Otol., 130 (S2), S75-S82. DOI: 10.1017/S0022215116000487.
Matos, J.P., Castro Silva, J., & Monteiro, E. (2012). Causes of death in patients with laryngeal cancer in stages I and II. Acta Med. Port., 25 (5), 317-322.
Hill-Madsen, L., Kristensen, C.A., Andersen, E., Johansen, J., Andersen, L.J., Primdahl, H., …, & Lyhne, N.M. (2019). Subglottic squamous cell carcinoma in Denmark 1971–2015 – a national population-based cohort study from DAHANCA, the Danish Head and Neck Cancer group. Acta Oncol., 58 (10), 1509-1513. DOI: 10.1080/0284186X.2019.1645355.
World Health Organization. (2020). The Global Cancer Observatory. Retrieved from: https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf
Chen, A.Y., Matson, L.K., Roberts, D., & Goepfert, H. (2001). The significance of comorbidity in advanced laryngeal cancer. Head Neck., 23 (7), 566-572. DOI: 10.1002/hed.1079.
Bosetti, C., Garavello, W., Levi, F., Lucchini, F., Negri, E., & La Vecchia, C. (2006). Trends in laryngeal cancer mortality in Europe. Int. J. Cancer, 119 (3), 673-681. DOI: 10.1002/ijc.21855.
Nocini, R., Molteni, G., Mattiuzzi, C., & Lippi, G. (2020). Updates on larynx cancer epidemiology. Chin. J. Cancer Res., 32 (1), 18-25. DOI: 10.21147/j.issn.1000-9604.2020.01.03.
Charlson, M., Szatrowski, T.P., Peterson, J., & Gold, J. (1994). Validation of a combined comorbidity index. J. Clin. Epidemiol., 47 (11), 1245-1251. DOI: 10.1016/0895-4356(94)90129-5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Bulletin of Social Hygiene and Health Protection Organization of Ukraine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
