INFLUENCE OF PSYCHO-VEGETATIVE DISORDERS ON COGNITIVE STATUS AND QUALITY OF LIFE OF PATIENTS WITH CORONARY ARTERY DISEASE
DOI:
https://doi.org/10.11603/1681-2786.2019.3.10588Keywords:
coronary heart disease, hypertension, psycho-autonomic disorders, cognitive status, quality of lifeAbstract
Purpose: to study the influence of psycho-vegetative disorders, cognitive status and quality of life of patients with coronary artery disease with hypertension.
Materials and Methods. In a prospective monocenter, a double-open study in parallel groups involved 56 patients with CHD: stable angina pectoris of II-III functional class comorbid with hypertension aged 42 to 68 years (median age – 5.0 (54.0; 65.0) years, 26 women, 30 men). All patients underwent a comprehensive clinical examination according to generally accepted standards. ADD detection was performed using the HADS Hospital Alarm and Depression Scale; detection of cognitive impairment – using the Montreal Cognitive Functional Assessment Scale (MOSA), a quality of life study was conducted using the Seattle Questionnaire (SAQ) and the SF-36 questionnaire; assessment of autonomic dysfunction – using temporal and spectral indicators of heart rate variability (HRV). Depending on the presence of ADD patients were distributed as follows: group 1 – 34 patients in combination with ADD and group 2– 22 patients without ADD.
Results. In patients with CHD and hypertension with ADD, compared with patients without ADD, an autonomic imbalance was observed with a decrease in overall heart rate variability, predominance of sympathetic link activity against the background of parasympathetic effects suppression. In patients with coronary artery disease with hypertension with ADD revealed a deterioration in the quality of life of patients according to the Seattle questionnaire and general health questionnaire SF-36, as well as a moderate decrease in cognitive function by Moss. A positive correlation between total anxiety and depression and cognitive deficits (r = + 56; p <0.05), QOL quality of life (r = + 0.54; p <0.05), AF (r = + 0.50; p <0.05), LF / HF ratio (r = + 0.44; p <0.05), reverse with SDNN (r = + 0.34; p <0.05).
Conclusions. Associations between anxiety-depressive, autonomic disorders and deterioration of QOL components and cognitive status in patients with CHD comorbid with hypertension were revealed.
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