MEDICAL AND SOCIAL ASPECTS OF REHABILITATIVE TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND COMORBID DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1681-2786.2018.4.10034Keywords:
myocardial infarction, diabetes mellitus, cardiac rehabilitation, Charlson Comorbidity IndexAbstract
Purpose: to establish criteria for readiness for rehabilitation of patients with myocardial infarction (MI), depending on the presence of comorbid diabetes mellitus, taking into account the peculiarities of the functional condition of the body.
Materials and Methods. 371 patients with acute myocardial infarction and comorbid pathology were examined. Diagnosis, treatment and rehabilitation of the patients were performed according to the current protocols.
Results. An in-depth statistical analysis proved the influence of comorbid diabetes mellitus on various functional systems of the acute MI patient and other marker parameters that could be used to control metabolic, hemodynamic and regulatory disorders in restoring health in patients with MI. In addition to glucose, as the traditional marker of comorbid diabetes, other parameters included a level of fibrinogen, INR, ECR, number of peripheral blood lymphocytes, duration of history of arterial hypertension, and Charlson Comorbidity Index. In case of MI complications, prevalent in patients with diabetes mellitus, left ventricular aneurysm and Dressler syndrome were more commonly diagnosed in these patients.
Conclusions. 1. The combination of myocardial infarction with comorbid diabetes mellitus is an independent predictor of the worst functional condition of the body, and such patients often suffer from MI complications and cardiac insufficiency, requiring more thorough monitoring of marker functional parameters, and an individual approach to rehabilitation measures.
2. An integral parameter for assessing the functional condition of a patient when planning rehabilitation measures may be the Charlson Comorbidity Index, which quantitatively reflects the degree of comorbidity in patients with diabetes mellitus.
References
Moroz, D.M., Manoilenko, T.S., Dorohoi, A.P., Handziuk, V.A., & Revenko, I.L. (2016). Problemy zdorovia i medychnoi dopomohy ta model pokrashchennia v suchasnykh umovakh: posibnyk [Problems of health and medical care and the model of improvement in modern conditions: manual]. Kovalenko, V.M., & Kornatskyi, V.M. (Ed.) Kyiv: Hordon [in Ukrainian].
Shumakov, V.O., Malynovska, I.E., Tereshkevych, L.P., Voloshyna, O.V., & Kisilevych, L.F. (2013). Kliniko-statystychni ta kliniko-funktsionalni pokaznyky u patsiientiv z hostrym infarktom miokarda pry suputnomu tsukrovomu diabeti [Clinico-statistical and clinical-functional parameters in patients with acute myocardial infarction with concomitant diabetes mellitus]. Ukrainskyi kardiolohichnyi zhurnal – Ukrainian Cardiology Journal, 1, 33-36 [in Ukrainian].
Barkoudah, E., Skali, H., Uno, H., Solomon, S.D., & Pfeffer, M.A. (2012). Mortality rates in trials of subjects with type 2 diabetes. J. Am. Heart Assoc, 1 (1), 8-15.
Taylor, K.S., Heneghan, C.J., Farmer, A.J., Fuller, A.M., Adler, A.I., Aronson, J.K., & Stevens, R.J. (2013). All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large U.K. primary care data base. Diabetes Care, 36 (8), 2366-2371.
Shumakov, V.A., Malinovskaya, I.E., Tereshkevich, L.P., Voloshina, O.V., Kryachok, T.A., Gotenko, I.A., & Kisilevich, L.F. (2013). Sakharnyy diabet u bolnykh ostrym infarktom miokarda: kliniko-biokhimicheskiye i funktsionalnyye kharakteristiki [Diabetes mellitus in patients with acute myocardial infarction: clinical, biochemical and functional characteristics]. Ukrainskyi kardiolohichnyi zhurnal – Ukrainian Cardiological Journal, 6, 28-32 [in Ukrainian].
Zinman, B., Ruderman, N., Campaigne, B.N., DEVLIN, J.T., & Schneider, S.H. (2003). American Diabetes Association. Physical activity/exercise and diabetes mellitus. Diabetes Care, 26 (Suppl. 1), S73-S77.
Kränkel, N., Bahls, M., Van Craenenbroeck, E.M., Adams, V., Serratosa, L., Solberg, E.E., … & Kemps, H. (2018). Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work? Eur. J. Prev. Cardiol., 15, 2047487318805158. DOI: 10.1177/2047487318805158.
Pett, M.A. (1997). Nonparametric statistics for health care research: Statistics for small samples and unusual distributions. Thousand Oaks, CA: Sage Publications.
Beckman, J.A., Paneni, F., Cosentino, F., & Creager, M.A. (2013). Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: part II. Eur. Heart J., 34, 2444-2452
Timmer, J.R., Hoekstra, M., Nijsten, M.W., van der Horst, I.C., Ottervanger, J.P., Slingerland, R.J., … & van ‘t Hof, A.W. (2011). Prognostic value of admission glycosylated hemoglobin and glucose in nondiabetic patients with ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention. Circulation, 124, 704-711.
Ryden, L., Grant, P.J., Berne, C., Cosentino, F., Danchin, N., … & Xuereb, R.G. (2013). ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur. Heart J., 34 (39), 3035-3087.
Sarwar, N., Gao, P., Seshasai, S.R., Gobin, R., Kaptoge, S., Di Angelantonio, E., … & Danesh, J. (2010). Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet., 26, 375 (9733), 2215-22. doi: 10.1016/S0140-6736(10)60484-9.
Topchiy, I.I. (2008). Neytrofily i monotsity pri povrezhdenii sosudistogo endoteliya kak zvenya yedinoy patogeneticheskoy tsepi v razvitii khronicheskoy bolezni pochek i ateroskleroza [Neutrophils and monocytes with damage to the vascular endothelium as links of a single pathogenetic chain in the development of chronic kidney disease and atherosclerosis]. Zhurnal “Vnutrennyaya meditsina” – Journal “Internal Medicine”, 56 (11-12), 40-45 [in Russian].
Prystupiuk, O.M. (2013). Biomarkery ta factory ryzyku sertsevo-sudynnykh urazhen u khvorykh na tsukrovyi diabet typu 2 [Biomarkers and factors of the risk of cardiovascular diseases in patients with type 2 diabetes mellitus]. Likarska sprava – Medical Practice, 1, 73-76 [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).