ANTIOXIDANT THERAPY IN WOMEN WITH ENDOMETRIOSIS DEPENDENT INFERTILITY

Authors

  • S. V. Khmil I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine
  • I. I. Kulyk Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine
  • R. P. Mykula Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2018.4.10031

Keywords:

endometriosis, infertility, antioxidant therapy, assisted reproductive technologies

Abstract

Purpose: Increase the effectiveness of auxiliary reproductive technologies protocols using integrated pregravid therapy, in women with genital endometriosis infertility.

Materials and methods. A randomized, clinical trial was conducted on 104 pregnant women with infertility and histologically confirmed diagnosis of genital endometriosis. Infertility treatment for all patients was performed using auxiliary reproductive technologies - extracorporeal fertilization of IVF / ICSI.

Results. After inclusion in the assisted reproductive technology program, all women were screened and divided into 2 groups depending on the treatment protocol: The I group (control) included 51 patients with endometriosis-associated infertility, which was performed by the COS using a standard "long" protocol. This group was divided into 2 subgroups; Group II - (experimental) 53 women with endometriosis-associated infertility, who were undergoing a modified COS scheme. The evaluation of the effectiveness of treatment with the use of pergravidder therapy was based on the following parameters: total dose of p-FSH, duration of stimulation, the number of follicles in diameter greater than 17 mm at the time of the introduction of the trigger of final maturation of the follicles, the total efficiency of the oocyte-cumulus complexes obtained in transvaginal puncture, degree of maturity of oocytes, the frequency of degenerative changes in the egg, the percentage of fertilization, the crushing of embryos, the blastocyst yield.

Conclusions. Pregravidder therapy with a combination of inositol and vitamin D, increases the sensitivity of ovaries to stimulation and improves the results of assisted reproductive technologies. Conducting surgical interventions in patients with genital endometriosis of Grade I and II severity is recommended after stimulation of supraovulation in ART programs.

Author Biographies

S. V. Khmil, I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine

Director of the Medical Center “The Clinic of Professor Stefan Khmil”, Merited Figure of Science and Technology of Ukraine, Professor, Sc.D., an obstetrician-gynecologist of the highest category, an expert in reproductive medicine

I. I. Kulyk, Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine

Head of the Department of Reproduction in the Medical Center “The Clinic of Professor Stefan Khmil”. Obstetrician-gynecologist, Reproductive medicine specialist

R. P. Mykula, Medical Center “Professor S. Khmil Clinic”, Ternopil, Ukraine

embryologist in the Medical Center “The Clinic of Professor Stefan Khmil”

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Published

2019-04-18

How to Cite

Khmil, S. V., Kulyk, I. I., & Mykula, R. P. (2019). ANTIOXIDANT THERAPY IN WOMEN WITH ENDOMETRIOSIS DEPENDENT INFERTILITY. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (4), 56–63. https://doi.org/10.11603/1681-2786.2018.4.10031

Issue

No. 4 (2018)

Section

The science for health care practice

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