Immediate implantation and loading in conditions of local application of platelet-rich fibrin

  • Ya. E. Vares Danylo Halytskyi Lviv National Medical University
  • V. Z. Slipyi Danylo Halytskyi Lviv National Medical University
Keywords: platelet-rich fibrin, A-PRF, dental implantation, immediate loading, osteogenesis


Summary. Today, the issue of stimulation of osteogenesis, prophylaxis of the atrophy of the margin of the alveolar bone, the protection around the implant bed from the ingestion of the connective tissue epithelium and the creation of sufficient volume of keratinized gums with excellent aesthetic parameters, especially in cases of immediate implantation and loading in the aesthetic zone is really urgent. 

The aim of the study – to learn the efficacy of local application of platelet-rich fibrin (PRF) produced by A-PRF+ technology in immediate implantation and loading in the frontal area.

Materials and Methods. The material of the research was included defects of the dentition in the frontal area and the nosology, the protocol of treatment of which required simultaneous removal of the tooth and immediate implantation.

Results and Discussion. The average duration of inpatient treatment was 3.5 days, while the period from the installation of the implant to the prosthesis was on average 3 days. The terms of complete epithelization of the wound and removal of sutures averaged 8.5 days. In all patients, the aesthetic and functional results of implant treatment using one-stage compression screw implants in combination with A-PRF+  were evaluated as perfect. In general, patients noted a significant and rapid improvement in dental health and quality of life after treatment.

Conclusions. Immediate implantation and loading in conditions of local application of PRF are a method of choice in different sites of the upper and lower jaw, especially in the aesthetic zone against a background of deficit or minimal proposal of bone tissue. The local application of PRF helps to facilitate the postoperative period, significantly improves both the condition of soft tissues around the implant and the aesthetic-functional indicators of ultimate rehabilitation, improving the quality of life of patients.


Belei, O.L., & Honcharuk-Khomyn, M.Iu. (2018). Analiz rezultativ vykorystannia pokhidnykh plazmy krovi pid chas protsedury dentalnoi implantatsii u patsiientiv pokhyloho viku [Analysis of the results of the most recent plasma of blood plasma during a procedure of dental implantation in a patient of a senile age]. Zhurnal klinichnykh ta eksperymentalnykh medychnykh doslidzhen – Journal of Clinical and Experimental Medical Researches, 5 (1), 52-62 [in Ukrainian].

Simonpieri, A. (2003). Subkrestalna implantatsiia. Mystetstvo keruvannia obsiahom periimplantnykh tkanyn [Subcrystalline implantation. The art of managing the volume of peri-implant tissues]. Implantolohiia. Parodontolohiia. Osteolohiia – Implantology. Periodontics. Osteology, 4, 39-45 [in Ukrainian].

Montanari, M., Callea, M., Yavuz, I., & Maglione, M. (2013). A new biological approach to guided bone and tissue regeneration. Case Reports, (apr09 1), bcr2012008240.

Mohamed, J.B., Alam, M.N., Singh, G., & Chandrasekaran, S.N. (2014). Alveolar bone expansion for implant placement in compromised aesthetic zone - case series. Journal of clinical and diagnostic research. JCDR, 8 (2), 237-238.

Boora, P., Rathee, M., & Bhoria, M. (2015). Effect of platelet rich fibrin (PRF) on peri-implant soft tissue and crestal bone in one-stage implant placement: A randomized controlled trial. Journal of Clinical and Diagnostic Research: JCDR, 9 (4), ZC18-ZC21.

Krasny, K., Kamiński, A., Krasny, M., Zadurska, M., Piekarczyk, P., & Fiedor, P. (2011). Clinical use of allogeneic bone granulates to reconstruct maxillary and mandibular alveolar processes. Transplantation Proceedings, 43 (8), 3142-3144.

Kocyigit, I.D., Tuz, H.H., Alp, Y.E., Atil, F., Tekin, U., & Coskunses, F.M. (2012). Correction of postsurgical alveolar ridge defect with vertical alveolar distraction of the onlay block graft. J Craniofac Surg., 23 (5),1550-1552. doi: 10.1097/SCS.0b013e31825c74b4.

Hamzacebi, B., Oduncuoglu, B., & Alaaddinoglu, E. (2015). Treatment of peri-implant bone defects with platelet-rich fibrin. The International Journal of Periodontics & Restorative Dentistry, 35 (3), 415-422.

Toffler, M., Toscano, N., Holtzclaw, D., Corso, M.D., & Dohan Ehrenfest, D.M. (2009). Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J. Implant. Adv. Clin. Dent., 1, 21-30.

Khomich, I., Rubnikovich, S., & Khomich, S. (2015). Immediate implantation and early functional loading with the use of ultrasound and autologous platelet-rich fibrin. International Journal of Oral and Maxillofacial Surgery, 44, e242.

Marrelli, M., & Tatullo, M. (2013). Influence of PRF in the healing of bone and gingival tissues. Clinical and histological evaluations. Eur. Rev. Med. Pharmacol. Sci., 17, 1958-1962.

Mourão, C.F.A.B., & Mourão, N.B.M.F. (2015). Plateletrich fibrin membrane in immediate dental implant loading. Dental Press Implantol., 9 (1), 104-109.

Öncü, E., & Alaaddinoğlu, E. (2015). The effect of platelet-rich fibrin on implant stability. The International Journal of Oral & Maxillofacial Implants, 30 (3), 578-582.

Fujioka-Kobayashi, M., Miron, R.J., Hernandez, M., Kandalam, U., Zhang, Y., & Choukroun, J. (2017). Optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. Journal of Periodontology, 88 (1), 112121.

Peck, M.T., Marnewick, J., & Stephen, L. (2011). Alveolar ridge preservation using leukocyte and platelet-rich fibrin: A report of a case. Case Reports in Dentistry, 1-5.

Choukroun, J., Diss, A., Simonpieri, A., Girard, M.-O., Schoeffler, C., Dohan, S. L., & Dohan, D.M. (2006). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 101 (3), 299-303.

Toffler, M. (2014). Guided bone regeneration (GBR) using cortical bone pins in combination with leukocyte- and platelet-rich fibrin (L-PRF). Compend. Contin. Educ. Dent., 35 (3), 192-198.

How to Cite
Vares, Y. E., & Slipyi, V. Z. (2019). Immediate implantation and loading in conditions of local application of platelet-rich fibrin. Clinical Dentistry, (2), 42-49.
Surgical stomatology