CEREBROPROTECTION BY GERMANIUM COORDINATION COMPOUNDS IN EXPERIMENTAL ACUTE GLOBAL BRAIN ISCHEMIA

  • V. D. Lukianchuk Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine
  • I. I. Seifullina Odesa I. I. Mechnikov National University, Odesa
  • O. E. Martsinko Odesa I. I. Mechnikov National University, Odesa, Ukraine
  • O. O. Shevchuk Ternopil State Medical University, Ternopil
Keywords: global brain ischemia, germanium coordination compounds, screening.

Abstract

Background. Stroke is among the leading causes of death and disability worldwide with rising incidence among young people today. This is the third most common cause of disability-adjusted life-years worldwide

Objective. The present study evaluated the cerebroprotective action of coordination compounds of germanium with underlying global cerebral ischemia in rats.

Methods. Global cerebral infarction was induced by bilateral common carotid artery occlusion. For primary screening we used numerous bis(citrate) germanates (stannates) compounds, which contained different metals: OL1-8, and VITAGERM-1,2,3 and 4. All germanium complexes used were injected intraperitoneally (1 % aqueous solution at a dose of 50 and 100 mg/kg in 35 min after bilateral common carotid artery occlusion). Piracetam was used as a reference drug. Criteria of cerebroprotection efficacy: survival of rats (%), ET50 (median effective time), observational Irwin’s test.

Results. Almost all bis(citrate) germanates (stannates), which contained different metals, possessed anti-ischemic activity of different intensity. The exceptions were cobalt-containing OL-6 and OL-2 compounds. The most significant efficacy of all investigated indices (which exceeded even reference drug) was evidenced for VITAGERM-1 – a coordination compound of germanium, diethylenetriaminepentaacetic acid and lithium.

Conclusions. Results of our experiments are the substitution for further more profound pharmacological investigation of VITAGERM-1 for stroke cerebroprotection and its implementation into clinics.

Author Biography

O. O. Shevchuk, Ternopil State Medical University, Ternopil
MD, PhD, assistant-professor of Pharmacology and Clinical Pharmacology Department

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Published
2018-07-25
How to Cite
Lukianchuk, V., Seifullina, I., Martsinko, O., & Shevchuk, O. (2018). CEREBROPROTECTION BY GERMANIUM COORDINATION COMPOUNDS IN EXPERIMENTAL ACUTE GLOBAL BRAIN ISCHEMIA. International Journal of Medicine and Medical Research, (1). https://doi.org/10.11603/ijmmr.2413-6077.2018.1.9253
Section
Biomedical Sciences