EFFECTIVENESS OF CANEPHRON® N IN THE COMPLEX MANAGEMENT OF SUBCLINICAL GOUTY NEPHROPATHY
Background. The risk of chronic kidney failure increases by 3–10 times with the steady increasing of uric acid level in the blood. It is known that the protein fractions is closely correlated with the level of uric acid.
Objective. Microalbuminuria and microglobulinuria are predictors of kidney damage. The study involved 50 patients with gout who had never received preventive treatment of gouty nephropathy. We choosed Canephron N (Bionorica, Neumarkt, Germany) as a combined phytodrug with nephroprotective effect. All studied patients were men with obesity.
Results. According to standard examination kidney damage haven’t been found, but laboratory tests on microproteinuria showed that the vast majority of patients have signs of subclinical gouty nephropathy.
Conclusions. Canephron N in complex gout treatment helps to decrease uric acid level in the blood and increase its excretion.
Abdul-Ghani AS, El-Lati SG, Sacaan A, et al. Anticonvulsant effects of some Arab medicinal plants. Int J Crude Drug Res 1987; 25: 39–43.
Bratus V, Talaia T, Shumakov V. Obesity, insuline resistance, metabolic syndrome: basic and clinical aspects. The fourth wave, Kyiv, 413.
Brenner В. The kidney. 8th edition, 2007: Elsevier. – 1196 p.
Disorders of purine metabolism and gouty nephropaty [E-resource]. – Access mode: URL: http://www.lvrach.ru/2006/10/4534541/.
Dzhonnazarova D. Clinical and renal function in gout among residents of the Republic of Tajikistan. Abstract, 2013
Lukyanchuk E. Experience of the use of nimesulide for the relief of pain in gouty arthritis. The Ukrainian journal of rheumatology. No. 1 (51), 2013, 53–55.
European Scientific Cooperative on Phytotherapy. Centaurii herba (Centaury herb). In: ESCOP Monographs. 2nd ed. Stuttgart, Germany, and New York: Thieme-Verlag, 2003: 70–73.
European Scientific Cooperative on Phytotherapy. Rosmarini folium (Rosemary leaves). In: ESCOP Monographs. 2nd ed. Stuttgart, Germany, and New York: Thieme-Verlag; 2003: 429–436.
Gaybullaev AA, Kariev SS. Effects of the herbal combination Canephron_N on urinary risk factors of idiopathic calcium urolithiasis in an open study. Z Phytother 2013; 34: 16–20.
Gerald D, Nazia R, Fang N. Effect of Uratelowering Therapies on Renal Disease Progression in Patients with Hyperuricemia. The journal of Rheumatology, 2014. 955–962
Gracza L, Koch H, Löffler E. Isolierung von Rosmarinsäure aus Symphytum officinale und ihre antiinflammatorische Wirksamkeit in einem In-vitro. Modell. Arch Pharm 1985; 318:1090–1095.
Haloui M, Louedec L, Michel B, Lyoussi B. Experimental diuretic effects of osmarinus officinalis and Centaurium erythraea. J Ethnopharmacol 2000; 71: 465–472.
Hossamel Z, Brian F. Managing gout: How is it different in patients with chronic kidney disease? Cleveland clinical journal of medicine volume 77 / Number 12, 2010, 919–928.
Hovind P. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes. An inception cohort study. Diabetes. 2009. – V. 58. 1668–1671.
Jalal D. Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the coronary artery calcification in type 1 diabetes study. Nephrol Dial Transplant. 2010. N25. 1865–1869.
Kanbay M, Solak Y, Dogan E et al. Uric acid in hypertension and renal disease: The chicken or the egg? Blood Purif, 2010. – N 30. 288–295.
Kumarasamy Y, Nahar L, Cox PJ, et al. Bioactivity of secoiridoid glycosides from Centaurium erythraea. hytomedicine 2003; 10: 344–347.
Kumarasamy Y, Nahar L, Sarker SD. Bioactivity of gentiopicroside from the aerial parts of Centaurium erythraea. Fitoterapia 2003; 74: 151–154.
Martynyuk L, Martynyuk L, Ruzhitska O, Martynyuk O. Effect of the Herbal Combination Canephron N on Diabetic Nephropathy in Patients with Diabetes Mellitus: Results of a Comparative Cohort Study. The journal of alternative and complementary medicine, 2014, 1–7.
Microalbuminuria [E-resource]. – Access mode: URL: http://www.indap.info/mikroalbuminuriya.html.
Naber KG. Efficacy and safety of the phytotherapeutic drug Canephron_N in prevention and treatment of urogenital and gestational disease: review of clinical experience in Eastern Europe and Central Asia. Res Rep Urol 2013; 5: 39–46.
Novitsky V. Pathophysiology. Edited. Vladimir Novitsky, ED Goldberg, OI Urazova. – M .: GEOTAR Media, 2009. – T. 2. – with 848.
Rampart M, Beetjens JR, Bult H, et al. omplementdependent stimulation of prostacyclin biosynthesis; inhibition by rosmarinic acid. Biochem Pharmacol 1986; 35: 1397–1400.
Richard J, Takahiko N, Diana J, Laura G et al. Uric acid and chronic kidney disease: which is chasing which? Nephrology Dialysis Transplantation. Volume 28, Issue 9. 2221–2228.
Shuba N, Voronov T, Tkachenko N. Influence of complex phytodrug Canephron N on the level of uric acid in patients with hyperuricemia and arterial hypertension. ML №1 (77) 2011. 77–79.
Sterner W, Heisler E, Popp HO, Fischer H. Studien über die Canephron-Wirkung bei chronischen Nierenerkrankungen. Physikalische Medizin Rehabilitation 1973; 14: 239–258.
Testa A, Mallamaci F, Spoto B et al. Association of a Polymorphism in a Gene Encoding a Urate Transporter with CKD Progression. Clinical Journal of the American Society of Nephrology, 2014. 1059–1065.
The study of renal function [E-resource]. – Access mode: URL: http://www.biochemmack.ru/upload/uf/204/2042dda688fc61b5d5db08ad2350d6dc.pdf.
Valentao P, Fernandes E, Carvalho F, et al. Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine 2003;10: 517–522.
Viazzi F, Leoncini G, Ratto E et al. Mild hyperuricemia and subclinical renal damage in untreated primary hypertension. AJH, 2007. V. 20; 1276–1282.
Weiner D. Uric acid and incident kidney disease in the community. J Am Soc Nephrol, 2008. – V. 19, N 6. 1204–1211.
Yamahara J, Konoshima I, Sawada I, Fujimura H. Biologically active principles of crude drugs: pharmacological actions of Swertia japonica extracts, swertiamarine and gentianine. Yakugaku Zasshi 1978; 98: 1446–1451.
Yarnell E. Botanical medicines for the urinary tract. World J Urol 2002; 20: 285–293.
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