INFLUENCE OF COGNITIVE FUNCTIONING ON THE EFFECTIVENESS OF TREATMENT OF VETERANS WITH POST-TRAUMATIC STRESS DISORDER AND MILD TRAUMATIC BRAIN INJURY
DOI:
https://doi.org/10.61751/ijmmr/2.2023.30Keywords:
stress-related mental disorder, brain injury, cognitive disorders, executive function, treatment, veterans, comorbidityAbstract
A history of traumatic brain injury in veterans is associated with higher use of mental health services, regardless of psychiatric diagnoses, which makes it important to develop a comprehensive approach to treatment and evaluate its effectiveness. The study aimed to investigate the impact of cognitive functioning among 329 veterans with comorbid post-traumatic stress disorder and mild traumatic brain injury on the effectiveness of combination therapy. The following tests were used to assess cognitive functioning: the Ray-Osterritz test, the Symbolic Communication Test, the Stroop test, and the Verbal Fluency Test. Functioning was assessed using the World Health Organization Questionnaire for the Assessment of Disability. The effectiveness of the combination therapy was also assessed using the Four-Dimensional Symptom Inventory. The influence of cognitive functioning on the effectiveness of 8-week complex therapy for veterans with this comorbidity was confirmed. The results of the Trail Making Test had statistically significant negative correlations with the cognitive sphere scale (ρ = -0.237; p = 0.0117) and the integral index of the World Health Organization questionnaire for the assessment of disability (ρ= -0.192; p = 0.0424), as well as positive correlations with the scales of self-care (ρ = 0.2038; p = 0.0311) and daily activity (ρ = 0.2048; p = 0.0303). It was found that patients with post-traumatic stress disorder, mild traumatic brain injury and their comorbidity responded differently to therapy, which was determined by the clinical features of their cognitive processes, namely associative performance, control rigidity/flexibility, attention, working memory and executive function. The dynamics of cognitive functioning differed in each group. It was also found that cognitive symptoms were targeted by therapy, as evidenced by their reduction after the intervention. The data obtained will allow for a more efficient and comprehensive organization of specialised psychiatric care for veterans, and cognitive functioning is predictive of the effectiveness and duration of treatment
Received: 14.08.2023 | Revised: 16.10.2023 | Accepted: 28.11.2023
References
Chebotaryova L, Kovalenko O, Solonovych A, Solonovych O. Posttraumatic stress disorder and mild traumatic brain injury – common consequences of war: Issues of pathogenesis and differential diagnosis (review). Fam Med Eur Pract. 2023;(2):64–72. DOI: 10.30841/2786-720X.2.2023.282496
Simonovic M, Nedovic B, Radisavljevic M, Stojanovic N. The Co-occurrence of post-traumatic stress disorder and depression in individuals with and without traumatic brain injury: A comprehensive investigation. Medicina. 2023;59(8):e1467. DOI: 10.3390/medicina59081467
Bisson JI. Prevention and treatment of PTSD: The current evidence base. Eur J Psychotraumatol. 2021;12(1):e1824381. DOI: 10.1080/20008198.2020.1824381
Lippa SM, French LM, Brickell TA, Driscoll AE, Glazer ME, Tippett CE, et al. Post-traumatic stress disorder symptoms are related to cognition after complicated mild and moderate traumatic brain injury but not severe and penetrating traumatic brain injury. J Neurotrauma. 2021;38(22):3137–45. DOI: 10.1089/neu.2021.0120
Timmer ML, Jacobs B, Schonherr MC, Spikman JM, van der Naalt J. The spectrum of long-term behavioral disturbances and provided care after traumatic brain injury. Front Neurol. 2020;11:e246. DOI: 10.3389/fneur.2020.00246
Kong LZ, Zhang RL, Hu SH, Lai JB. Military traumatic brain injury: A challenge straddling neurology and psychiatry. Mil Med Res. 2022;9:e2. DOI: 10.1186/s40779-021-00363-y
Shively SB, Priemer DS, Stein MB, Perl DP. Pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and neuropsychiatric clinical expression. Psychiatr Clin North Am. 2021;44(3):443–58. DOI: 10.1016/j.psc.2021.04.003
Marklund N, Vedung F, Lubberink M, Tegner Y, Johansson J, Blennow K, et al. Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients – A PET/MR study. Neuroimage Clin. 2021;30:e102665. DOI: 10.1016/j.nicl.2021.102665
Ng SY, Lee AYW. Traumatic brain injuries: Pathophysiology and potential therapeutic targets. Front Cell Neurosci. 2019;13:e528. DOI: 10.3389/fncel.2019.00528
Graham NSN, Cole JH, Bourke NJ, Schott JM, Sharp DJ. Distinct patterns of neurodegeneration after TBI and in Alzheimer's disease. Alzheimer's Dement. 2023;19(7):3065–77. DOI: 10.1002/alz.12934
Harrington DL, Hsu PY, Theilmann RJ, Angeles-Quinto A, Robb-Swan A, Nichols S, et al. Detection of chronic blast-related mild traumatic brain injury with diffusion tensor imaging and support vector machines. Diagnostics. 2022;12(4):e987. DOI: 10.3390/diagnostics12040987
Dhote VV, Samundre P, Upaganlawar AB, Ganeshpurkar A. Gene therapy for chronic traumatic brain injury: Challenges in resolving long-term consequences of brain damage. Curr Gene Ther. 2023;23(1):3–19. DOI: 10.2174/1566523221666211123101441
Classification of Health Problems and Related Issues [Internet]. 2021 [cited 2024 Feb 13]. NC 025:2021. Available from: https://www.dec.gov.ua/wp-content/uploads/2021/11/naczionalnyj-klasyfikator-nk-025.pdf
On Amendments to the Guideline “Medicinal Products. Proper Clinical Practice ST-N MOZU 42-7.0:2008”, Order of the Ministry of Health of Ukraine No. 1169 [Internet], 2017 Sep 26 [cited 2024 Feb 13]. Available from: https://zakon.rada.gov.ua/rada/show/v0095282-09#Text
The Convention on Human Rights and Biomedicine: Convention on Human Rights and Biomedicine. 1997. Oviedo. Spain. Available from: https://zakon.rada.gov.ua/laws/show/994_334#Text
The World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects [Internet]. Available from: https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/
Ethical Code of the Scientist of Ukraine, Resolution of the General Meeting of the National Academy of Sciences of Ukraine No. 2, Apr 15, 2009. Available from: https://zakon.rada.gov.ua/go/v0002550-09
Üstün TB, Kostanjsek N, Chatterji S, Rehm J, editors. Measuring health and disability: Manual for WHO disability assessment schedule (WHODAS 2.0) [Internet]. Geneva: WHO Press; 2010 [cited 2024 Feb 13]. 152 p. Available from: https://iris.who.int/bitstream/handle/10665/43974/9789241547598_eng.pdf?isAllowed=y&sequence=1
Mayer AR, Quinn DK. Neuroimaging biomarkers of new-onset psychiatric disorders following traumatic brain injury. Biol Psychiatry. 2022;91(5):459–69. DOI: 10.1016/j.biopsych.2021.06.005
Patel JB, Wilson SH, Oakes TR, Santhanam P, Weaver LK. Structural and volumetric brain MRI findings in mild traumatic brain injury. AJNR Am J Neuroradiol. 2020;41(1):92–99. DOI: 10.3174/ajnr.A6346
Stein MB, Yuh E, Jain S, Okonkwo DO, Mac Donald CL, Levin H, et al. Smaller regional brain volumes predict posttraumatic stress disorder at 3 months after mild traumatic brain injury. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6(3):352–59. DOI: 10.1016/j.bpsc.2020.10.008
Esagoff AI, Stevens DA, Kosyakova N, Woodard K, Jung D, Richey LN, et al. Neuroimaging correlates of post-traumatic stress disorder in traumatic brain injury: A systematic review of the literature. J Neurotrauma. 2023;40(11-12):1029–44. DOI: 10.1089/neu.2021.0453
de Souza NL, Esopenko C, Jia Y, Parrott JS, Merkley TL, Dennis EL, et al. Discriminating mild traumatic brain injury and posttraumatic stress disorder using latent neuroimaging and neuropsychological profiles in active-duty military service Members. J Head Trauma Rehabil. 2023;38(4):254–66. DOI: 10.1097/HTR.0000000000000848
Siddiqi SH, Kandala S, Hacker CD, Bouchard H, Leuthardt EC, Corbetta M, et al. Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury. Sci Transl Med. 2023;15(703):eabn0441. DOI: 10.1126/scitranslmed.abn0441
McGrath H, Zaveri HP, Collins E, Jafar T, Chishti O, Obaid S, et al. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Sci Rep. 2022;12(1):e18778. DOI: 10.1038/s41598-022-21543-3
Ricchi I, Tarun A, Maretic HP, Frossard P, Van De Ville D. Dynamics of functional network organization through graph mixture learning. NeuroImage. 2022;252:e119037. DOI: 10.1016/j.neuroimage.2022.119037
Van Praag DLG, Van Den Eede F, Wouters K, Wilson L, Maas AIR, The Center-TBI Investigators And Participants. The impact of neurocognitive functioning on the course of posttraumatic stress symptoms following civilian traumatic brain Injury. J Clin Med. 2021;10(21):e5109. DOI: 10.3390/JCM10215109
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Olena Smashna

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.








