HEMODYNAMIC FEATURES OF PREGNANT WOMEN WITH ATRIAL SEPTAL DEFECT IN THE THIRD TRIMESTER OF PREGNANCY: A LITERATURE REVIEW
DOI:
https://doi.org/10.61751/ijmmr.2413-6077.2023.1.60Keywords:
congenital malformations, gestation, cardiovascular complications, risk factors, open oval window, pulmonary hypertensionAbstract
Due to the decline in mortality rates among children with heart disease, a significant number of such children have reached reproductive age. However, since knowledge about the impact of pregnancy on haemodynamics in women with heart disease is limited, this study is extremely relevant. The study aimed to provide a comprehensive review of current scientific sources and consolidate the knowledge gained on haemodynamic features in pregnant women with atrial septal defects. Several methods were used in the study: analysis, including comparative analysis, synthesis, bibliography, systematisation, and categorisation. A two-stage approach in the form of a systematic literature review was also used. The complex haemodynamic changes that occur in pregnant women, both in normal and pathological conditions, in particular in pregnant women with atrial septal defect, are considered. The question is specified as to why hemodynamic changes become most significant in the third trimester of pregnancy, their impact on the course of pregnancy, and the outcome of labor completion. The topic of acute and chronic complications of atrial septal defect and modern principles of their prevention and treatment are covered. Special attention is paid to the methods of correction of this heart defect, considering their advantages, disadvantages and possible complications. The experience of perinatal centres in several European countries in managing pregnancies in women with cardiovascular disease, in particular with atrial septal defects, is reviewed. Gaps in knowledge about the prevalence of these defects and risk factors were filled. The study addressed the lack of a comprehensive view of this problem: from pathophysiological basis and epidemiology to treatment and modification of risk factors. The study is of great practical value for healthcare professionals, as it can serve as a basis for the development of preventive programmes and other interventions for pregnancies of women with congenital cardiovascular disease
Received: 24.02.2023 | Revised: 03.05.2023 | Accepted: 30.05.2023
References
Yaroslavskyi V, Tsysar Yu. Modern views on the course of cardiovascular pathology during pregnancy. Med Forum. 2021;24(24):102–4
Triska S, Vasiuk, Yu, Yashan N. Congenital and acquired heart defects and pregnancy: Features of pregnancy and delivery management. South Ukr Med Sci J. 2019;23(23):11–3
Kravchuk I, Kurtash N, Kusa O, Neiko O, Snizhko T. Algorithm for the management of pregnant women with thrombophilia. In: Pluzhnik E, Polyvana L, Mushenyk I, Prudka L, Marchenko D, Harchenko R, et al., editors. Young Scientists and Methods of Improving Modern Theories. Proceedings of the II International Scientific and Practical Conference; 2023; Milan, Italy. International Science Group. 2023. P. 110–4. DOI: 10.46299/ISG.2023.2.2
Kryvetskyi V, Rotar H, Protsak T, Shafraniuk V. Congenital heart defects: Current state and present issues. Clin Anat Oper Surg. 2018;17(1):108–13. DOI: 10.24061/1727-0847.17.1.2018.18
Shevchenko T, Shaposhnyk O, Sorokina S, Kudrya I, Efremenko V. Features of management of patients with late diagnosed congenital heart disease. World Med Biol. 2019;1(67):111–16. DOI: 10.26724/2079-8334-2019-1-67-111
Boell SK, Cecez-Kecmanovic D. On being “systematic” in literature reviews in IS. J Inform Technol. 2015;30(2):161–73. DOI: 10.1057/jit.2014.26
Khudoykulova N. Congenital anomalies, their analysis and development in the Navoi region. Int J Philos Stud Soc Sci. 2022;2(2):46–49
Protsak T, Khovanets K. Developmental cardiovascular anomalies. Med Forum. 2018;15(15):61–63.
Murzakanova G, Räisänen S, Jacobsen AF, Yli BM, Tingleff T, Laine K. Trends in term intrapartum stillbirth in Norway. JAMA Netw Open. 2023;6(9):e2334830. DOI: 10.1001/jamanetworkopen.2023.34830
Frescura C, Thiene G. In Thiene, G., Basso, C., Rizzo, S., Della Barbera, M., Valente, M., Bortolotti, U., editors. Congenital anomalies of the cardiac valves. Pathology of Cardiac Valve Disease. Cham: Springer International Publishing; 2023. P. 63–86. DOI: 10.1007/978-3-031-35498-4_5
Gelb BD. Prospects for precision genetic medicine in congenital heart disease. Curr Opin Genet Dev. 2022;77:e101983. DOI: 10.1016/j.gde.2022.101983
Wen X, Belviso N, Murray E, Lewkowitz AK, Ward KE, Meador KJ. Association of gestational opioid exposure and risk of major and minor congenital malformations. JAMA Netw Open. 2021;4(4):e215708. DOI: 10.1001/jamanetworkopen.2021.5708
Mallah N, Tohidinik HR, Etminan M, Figueiras A, Takkouche B. Prenatal exposure to macrolides and risk of congenital malformations: A meta-analysis. Drug Saf. 2020;43:211–21. DOI: 10.1007/s40264-019-00884-5
Liang Z, Yin M, Ma M, Wang Y, Kuang Y. Effect of maternal advanced endometriosis on risk of congenital malformations for infants born after in vitro fertilization and frozen-thawed embryo transfer: analysis of 28,600 newborns. Front Endocrinol. 2019;10:e763. DOI: 10.3389/fendo.2019.00763
Costa NZ, Nora CRD, Souto LHD, Carlotto FD, Afonso, RDS, Riquinho DL. Exposure to toxic agrochemicals and development of congenital malformations: A scoping review. Texto Contexto-Enfermagem. 2021;30:e20200372. DOI: 10.1590/1980-265X-TCE-2020-0372
de Ramírez-Altamirano MJ, Fenton-Navarro P, Sivet-Chiñas E, Harp-Iturribarria Fde M, Martínez-Cruz R, Cruz PH, et al. The relationship of aluminium and silver to neural tube defects; a case control. Iran J Pediatr. 2012;22(3):369–74
Seyi-Olajide JO, Ma X, Guadagno E, Ademuyiwa A, Poenaru D. Screening methods for congenital anomalies in low and lower-middle income countries: A systematic review. J Pediatr Surg. 2023;58(5):986–93. DOI: 10.1016/j.jpedsurg.2023.01.038
Xia Y, Cheng L, Duan J, Ma J, Zhang Y. Identification of gravida serum biomarkers for noninvasive prenatal diagnosis foetal congenital heart disease. J Cardiovasc Trans Res. 2023;16:255–66. DOI: 10.1007/s12265-022-10301-5
Konovalova M, Mykhailovska N. The impact of concomitant anemic syndrome on the clinical course of coronary artery disease. Pathol. 2021;18(3):263–8. DOI: 10.14739/2310-1237.2021.3.237926
Troiano NH. Physiologic and hemodynamic changes during pregnancy. AACN Adv Crit Care. 2018;29(3):273–83. DOI: 10.4037/aacnacc2018911
Ren J, Fan Z, Li J, Wang Y, Zhang J, Hua S. Blood pressure patterns of hypertensive disorders of pregnancy in first and second trimester and contributing factors: A retrospective study. J Obstet Gynaecol. 2023;43(1):e2171776. DOI: 10.1080/01443615.2023.2171776
Sima RM, Findeklee S, Bădărău IA, Poenaru MO., Scheau C, Pleș L. Comparison of maternal third trimester hemodynamics between singleton pregnancy and twin pregnancy. J Perinat Med. 2021;49(5):566–71. DOI: 10.1515/jpm-2020-0169
Pascual ZN, Langaker MD. Physiology, pregnancy [Internet]. Treasure Island: StatPearls Publishing; 2023 [cited 2023 Nov 28]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559304/
Warren BB, Moyer GC, Manco-Johnson MJ. Hemostasis in the pregnant woman, the placenta, the fetus, and the newborn infant. Semin Thromb Hemost. 2023;49(4):319–29. DOI: 10.1055/s-0042-1760332
Bester M, Joshi R, Mischi M, van Laar JOEH, Vullings R. On the distinct differences in autonomic regulation between pregnant and non-pregnant women-a heart rate variability analysis. Physiol Meas. 2023;44(5):e055001. DOI: 10.1088/1361-6579/acce1e
Binh VT, Thi H, Anh HD, Anh NT, Thanh BD, Pho DC, et al. Assessment of morphological and hemodynamic changes in adult atrial septal defect before and after percutaneous trans-catheter closure: The initial result in Vietnamese patient. Eur Rev Med Pharmacol Sci. 2022;26(24):9240–49. DOI: 10.26355/eurrev_202212_30677
Muroke V, Jalanko M, Haukka J, Sinisalo J. Cause‐specific mortality of patients with atrial septal defect and up to 50 years of follow‐up. J Am Heart Assoc. 2023;12(2):e027635. DOI: 10.1161/JAHA.122.027635
Sjöberg P, Arheden H, Heiberg E, Stephensen S, Carlsson M. Haemodynamic left-ventricular changes during dobutamine stress in patients with atrial septal defect assessed with magnetic resonance imaging-based pressure-volume loops. Clin Physiol Funct Imaging. 2022;42(6): 422–29. DOI: 10.1111/cpf.12781
Cool CJ, Kamarullah W, Pranata R, Putra ICS, Khalid AF, Akbar MR, et al. A meta-analysis of atrial septal defect closure in patients with severe pulmonary hypertension: is there a room for poking holes amidst debate? Curr Probl Cardiol. 2023:e102121. DOI: 10.1016/j.cpcardiol.2023.102121
Bradley EA, Zaidi AN. Atrial septal defect. Cardiol Clin. 2020;38(3):317–24. DOI: 10.1016/J.CCL.2020.04.001
Potapchuk A, Onipko Y, Almashi V, Rak Y, Hegedűs C, Kryvanych V, Sheveria S. Evaluation of dynamic changes in the microcirculation of the mucosa in the zone of dental implantation with immediate intraoperative load. Med Adv. 2023;76(9):1891–9. DOI: 10.36740/WLek202309101
Kadirogullari E, Onan B, Timur B, Birant A, Reyhancan A, Basgoze S, Aydin U. Transcatheter closure vs totally endoscopic robotic surgery for atrial septal defect closure: A single‐center experience. J Card Surg. 2020;35(4):764–71. DOI: 10.1111/jocs.14456
Qiu HF, Chen Q, Hong Z-N, Chen LW, Huang XS. Transcatheter and intraoperative device closure and surgical repair for atrial septal defect. J Cardiothorac Surg. 2019;14:e136. DOI: 10.1186/s13019-019-0957-0
Seol JH, Jung SY, Lee HB, Kim AY, Kim EH, Min IK, et al. Outcomes in patients with pulmonary arterial hypertension underwent transcatheter closure of an atrial septal defect. J Clin Med. 2023;12(7):e2540. DOI: 10.3390/jcm12072540
Zwijnenburg RD, Baggen VJ, Geenen LW, Voigt KR, Roos-Hesselink JW, van den Bosch AE. The prevalence of pulmonary arterial hypertension before and after atrial septal defect closure at adult age: A systematic review. Am Heart J. 2018;201:63–71. DOI: 10.1016/j.ahj.2018.03.020
Ladouceur M, Benoit L, Radojevic J, Basquin A, Dauphin C, Hascoet S, et al. Pregnancy outcomes in patients with pulmonary arterial hypertension associated with congenital heart disease. Heart. 2017;103(4):287–92. DOI: 10.1136/heartjnl-2016-310003
Shevchenko A, Krut Yu. Evaluation of risk factors and modern possibilities for prediction of preterm labour. Zaporozhye Med J. 2019;21(6):759–63. DOI: 10.14739/2310-1210.2019.6.186500
Malakhova S, Syvolap V, Potapenko M. Features of cardiac remodeling depending on the mode of training session. Zaporozhye Med J. 2020;22(5):643–51. DOI: 10.14739/2310-1210.2020.5.214735
Khara M, Korda I, Podilska T. Gestational diabetus mellitus and its complications, role of desynchronosis in pathogenesis (a review). Pathologia. 2023;20(2):195–2. DOI: 10.14739/2310-1237.2023.2.282626
Loia N, Korchynska O, Herzanych S, Hetzko N. Characteristics of pregnancy and delivery in women with vitamin D deficiency. Zaporozhye Med J. 2020;22(4):440–45. DOI: 10.14739/2310-1210.2020.4.208347
Aleksieiev O. Perspective and current state of international standards influence on prevention and treatment of diseases through the prism of developing high-quality and safe medicines. Zaporozhye Med J. 2022;24(4):448–53. DOI: 10.14739/2310-1210.2022.4.256025
Zhang B, Li D, Song A, Ren Q, Cai S, Wang P, et al. Characteristics of patent foramen ovale: Analysis from a single center. Cardiol Res Pract. 2022;e5430598. DOI: 10.1155/2022/5430598
Chen L, Deng W, Palacios I, Inglessis-Azuaje I, McMullin D, Zhou D, et al. Patent foramen ovale (PFO), stroke and pregnancy. J Invest Med. 2016;64(5):992–1000. DOI: 10.1136/jim-2016-000103
Brida M, Chessa M, Celermajer D, Li W, Geva T, Khairy P, et al. Atrial septal defect in adulthood: A new paradigm for congenital heart disease. Eur Heart J. 2022;43(28):2660–71. DOI: 10.1093/eurheartj/ehab646
Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, et al. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010;31(17):2124–32. DOI: 10.1093/eurheartj/ehq200
Udholm S, Udholm L, Nyboe C, Kesmodel US, Hjortdal VE. Pregnancy outcome in women with atrial septal defect: Associated with in vitro fertilisation and pre-eclampsia. Open Heart. 2019;6(2):e001148. DOI: 10.1136/openhrt-2019-001148
Roos-Hesselink J, Baris L, Johnson M, De Backer J, Otto C, Marelli A, et al. Pregnancy outcomes in women with cardiovascular disease: Evolving trends over 10 years in the ESC registry of pregnancy and cardiac disease (ROPAC). Eur Heart J. 2019;40(47):3848–55. DOI: 10.1093/eurheartj/ehz136
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Serhii Nakonechnyi, Iryna Sokolovska, Iryna Hanzhyi

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.








