REGULATION OF OXIDATIVE STRESS AND LIPID PEROXIDATION INDUCED BY EPINEPHRINE: THE CORRECTIVE ROLE OF L-GLUTAMIC ACID
DOI:
https://doi.org/10.61751/ijmmr.2413-6077.2023.1.32Keywords:
activity, biochemical reactions, damage, antioxidant enzymes, ratsAbstract
Oxidative stress is related to the development of metabolic and chronic diseases. Mitigation and prevention
of the oxidative stress influence remain one of the most pressing issues in biology and medicine. The objective of the
research was to examine and compare the role of the glutamic acid, both individually and in combination with pyridoxine, in mitigating the oxidative stress effects elicited by epinephrine. Biochemical methods (determination of the
activity of antioxidant enzymes, alanine and aspartate aminotransferases, lipid peroxidation products) and statistical
methods were used in the research. The findings indicate that the additional use of L-glutamic acid, both individually
and in combination with pyridoxine, allows the body to reach control values or approach them to a greater extent than
in groups of animals that did not receive these substances. In particular, such data were found for the following indicators: restored glutathione, lipid hydroperoxides (third experimental group), glutathione peroxidase, thiobarbituric acid
reactive substances (second and third experimental groups), superoxide dismutase (spleen, liver, brain), catalase (liver,
brain). In contrast, in the first experimental group, which only experienced stress, the activity of superoxide dismutase
(spleen, brain, and liver) and catalase (brain, liver, and lungs) decreased compared to the control and the second and
third experimental groups. When modelling epinephrine-induced oxidative stress, L-glutamic acid, both individually
and in combination with pyridoxine, demonstrated a mitigating effect on the oxidant-antioxidant imbalance, which
is a key factor in the level of oxidative stress. The research has shown the potential application of L-glutamic acid for
mitigating and protecting the body during states accompanied by oxidative stress
Received: 01.03.2023 | Revised: 28.04.2023 | Accepted: 30.05.2023
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