(literature review)




dry socket, treatment, compositions, medicines, Flupetsal


Background. Tooth extraction is the most common surgical intervention in the outpatient practice of a dental surgeon. In most cases, bone wound healing is uncomplicated. However, in some patients the course of healing is complicated by acute inflammatory process of dry socket (alveolar osteitis), the frequency of which increases with increasing trauma of surgery. In dentally healthy patients with typical tooth extraction, dry socket occurs in 2.55%, with difficult – in 9.84%, with atypical extraction of the lower wisdom tooth – in 31.03% of cases. In the presence of diabetes, the incidence of dry socket with typical removal is much higher and according to various authors it is 9.7-13.5%.

Objective. The aim of the research was to study the publications and their analysis on the current diagnosis, prevention and treatment of patients with dry socket.

Methods. Scientific sources were the articles in world periodicals on dental surgery and therapy, microbiology as well as some electronic resources and patents.

Results. At present, many techniques, methods, schemes, compositions for treatment of various forms of dry socket are established. Most often, antibacterial drugs or their combinations with other drugs are used. However, antibacterial drugs do not always have a pronounced anti-inflammatory effect due to the high resistance of the oral microflora. In these cases, contemporary drugs in the form of a composition with long-term antiseptic, anti-inflammatory and analgesic action are rational.

Conclusions. The action of a Flupetsal composition, which contains antimicrobial and immunomodulatory drug flurenizide, was clinically proven for treatment of patients with dry socket; the properties of the available ingredients provide a high disinfectant effect, prevent development of inflammation in the tissues and its transition to purulence. A contemporary effective method of treating patients with dry socket is carried out according to the developed method.

Author Biography


Associate Professor, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine


Varava GN, Tereshina TP, Raiswich OE, The organization of the work of oral hygiene offices for the prevention of dental diseases: guidelines. – Kyiv: 2008;42. [In Ukrainian].

Lomnitsky IYa. Propaedeutics of surgical dentistry. – Lviv: GalDent, 2001;114. [In Ukrainian].

Kovalenko VN. Compendium. – Kyiv: MORION. 2006;2270. [In Ukrainian].

Gumetsky RA, Zavadka OE, Rozhko MM. Psychological and medical training of patients in dental practice. – Lviv: Nautilus. 2000;135–40. [In Ukrainian].

Timofeev AA, Gorobets EV, Vesova EP. The experience of using the drug “ketones” in maxillo­facial surgery. Modern dentistry. 2003;2:73–5. [In Ukrainian].

Bernadsky YuI. Fundamentals of maxillofacial surgery and surgical dentistry. Bernadsky. – Vitebsk, 2003;416.

Livshits YaG, Timofeev GA, Sadkov SA. Application of antiseptic sponge with kanamycin in outpatient dental practice. Dentistry. 2004;1:92–7.

Baglyk TV. X-ray characteristics of norm and pathology in dentistry. Dentist. 2002;4:50–4.

Aupois R. Postextraction dry socket. Inf. Dent. 2006;88:19:29–32.

Dmitrieva AA, Ignatenko NM. The frequency of tooth extraction surgery depending on the pa­tient’s age and tooth location in the formula. Questions of experimental and clinical dentistry. 2001;4:128–30.

Iordanishvili AK. Treatment of dry socket with solcoseryl jelly and cream “Dermazin”. Health of Belarus. 1992;2:59–61.

Malanchuk VO, Ostapenko OO, Dobry-Vechir TV. Method of surgical treatment of difficult eruption of lower wisdom teeth. Visnyk stomatologii. 2006;2:69–70. [In Ukrainian].

Burgonsky VG. Modern technology of local anesthesia in dentistry. Modern dentistry. 2009;2:99.

Livshits YaG, Timofeev GA, Sadkov SA. Application of antiseptic sponge with kanamycin in outpatient dental practice. Dentistry. 2004;1:92–7.

Tomilin VV, Loganovskaya EN, Doroshenko SI. Hemostatic therapy of patients with mild and latent forms of coagulopathies and thrombocytopathies in surgical dental interventions. Dental technologies. 2003;2:7–8.

Guseva SA, Dubkova AG, Voznyuk VP. Here­ditary and acquired hematological syndromes in clinical practice. – Kiev: LOGOS. 2000;117– 46.

Mitchenok MP. Probable causes of dry socket in patients with type 2 diabetes. Bulletin of Dentistry. 2008;1:145–6. – Journal access mode. [In Ukrainian].


Iordanishvili AK. Prevention and treatment of complications arising after tooth extraction surgery. Dentist. 2001;3:19–21.

Chereda VV. Microflora as a factor in the occur­rence of inflammatory periodontal diseases. Ukrainian Dental Almanac. 2007;1:77–9. [In Ukrai­nian].

Moroz VM, Paliy GK, Sobolev VO. Comparative study of antimicrobial properties of antiseptics. Bul­letin of Vinnytsia State Medical University. 2002;2:315–20. [In Ukrainian].

Artyushkevich A, Roman G. Odontogenic infection: modern pathogenetic therapy. Dentist. 2004;2:46–9.

Ushakov RV, Tsarev VN, Ochirov E. Prevention of postoperative infectious complications. Dentist. 2004;4:20–4.

Goth I, Adamovich O, Masna-Chala O. Socially significant infections in dentistry. Lviv: “Compact-LV”. 2005;123. [In Ukrainian].

Ponur BA, Shikon YuN, Karmelyuk LO. Ana­lysis of antibiotic sensitivity of bacterial strains iso­lated from patients with purulent-inflammatory processes. Ukrainian Chemotherapeutic Journal. 2000;1:39–42. [In Ukrainian].

Lakhtin YV. Features of the clinic, diagnosis and treatment of generalized periodontitis in the invasion of oral protozoa: author dis. for science degree of Cand honey. Science: special. 14.01.22 “Dentistry” – Poltava. 1997;17. [In Ukrainian].

Biryukova SV. Interaction of normal micro­biota with macro organism. Clinical antibiotic the­rapy. 2000;2:8–11.

Savichuk NO, Savichuk OV. Microecology of the oral cavity, dysbacteriosis and ways of its cor­rection. Modern dentistry. 2002;4:7–9.

Tsarev VN, Ushakov RV. Antimicrobial pre­vention of inflammatory complications in surgical dentistry. Dentist. 2004;4:23–6.

Timofeev AA, Grokhotov VA. The severity of microbial sensitization in patients with dry socket. Modern dentistry. 2006;2:84–8. [In Ukrainian].

Tsarev VN, R. V. Ushakov Antimicrobial prevention of inflammatory complications in surgical dentistry. Russian Journal of Dentistry. 2003;4:21–5.

Zero AA. Relation between microbiological and clinical parameters in periodontal disease. J. Am. dent. Assoc. 2004;29:4:451–6.

Bloomer CR. Alveolar osteitis prevention by immediate placement of medicated packing. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2000;90:3:282–4.

Francetti L, Fabbro M, Testori T, Weinstein RL. Chlorhexidine spray versus chlorhexidine mouthwash in the control of dental plaque after periodontal surgery. J. Clin. Periodontol. 2000;27:6:425–30.

Leyes Borrajo JL, Garcia VL,. Lopez CG. Efficacy of chlorhexidine mouthrinses with and without alcohol: a clinical Study. J. Periodontol. 2002;73:3: 317–21.

Tsarev VN, Ushakov RV, Plakhtiy LYa. The use of adhesive films “Diplen-dent” in the complex treatment of periodontitis. Manual of dentistry. 2002;90.

Grishanin GG, Tsyganenko AYa. Pat. 21104U Ukraine, MKV6 A 61 C 17/00 Method of treatment of oral dysbiosis. Applicant and patent owner Kharkiv State Medical University – № u200611282; declared 26.10.06; publ. 15.02.07;2. [In Ukrainian].

Varenyeva NO. Antibacterial activity of a new antiseptic rinse for the mouth “Naturosept” and the effectiveness of its use for the prevention of dry socket. Dental technologies. 2008;4:16–7. [In Ukrainian].

Kovalchuk VP, Kondratyuk VM. New anti­septics of domestic production. Comparative cha­rac­­teristics of antimicrobial activity. Vinnytsia National Medical University named after Pirogov MI. Depart­ment of Microbiology, Immunology and Virology. The Art of Treatment. – Mode of access to magazines. [In Ukrai­nian].

Paliy VG, Barilo AS, Chesnokova AA. Pathogens of purulent-inflammatory diseases of the maxillofacial region and their sensitivity to antibiotics. Biomedical and Biosocial Anthropology. 2006;6:84–7. [In Ukrai­nian].

Baffo FG, Lossenberg RT. Hygiene of a cavity in surgical dentistry. Oral. Maxillofac. Surg. 2007;65: 3:315–8.

Kovalenko VN, Viktorova AP. Compendium 2006 – drugs. – Kyiv: Morion. 2006;2270. [In Ukrai­nian].

Skripnikov PN, Kolomiets SV. Combined antibiotics in the surgical treatment of periodontal diseases. Innovative technologies – in dental prac­tice: III (X) Congress of the Association of Dentists of Ukraine October 16–18 2008;326. [In Ukrainian].

Mozgovaya NV, Terezina TP, Varenyeva NO. Experimental study of a new antiseptic composition for the oral cavity. Bulletin of dentistry. 2007;4:142–3. [In Ukrainian].

Kovalchuk VP, Paliy VG, Grabik IM. Cha­racteristics of preventive and curative efficacy of a new domestic antiseptic drug gorosten. New Medi­cine. 2006;1 (24):72–5. [In Ukrainian].

Patent 17420 Ukraine, IPC A 61 K 31/14, 9/08. Antiseptic composition for skin disinfection “Goro­sten”. Paliy GK, Kovalchuk VP, Paliy VG, Vovk IM, Koget TO, Paliy IG. – application. 30.03.95;1. [In Ukrainian].

Grabik IM, Paliy VG. Prospects for the use of a new domestic antiseptic drug gorosten in the prevention of dental diseases. Biomedical and Biosocial Anthropology. 2006;6:56–9. [In Ukrainian].

Ipitovsky SB. Modern trends in the production of liquid oral hygiene. New in dentistry. 2001;4 (94):50–2.

Pat. 55125A Ukraine, IPC A 61 K 31/07, 33/04. Method of zaapical therapy of chronic apical perio­dontitis / Sinitsa VV, Zubchyk VM.; applicant and patent owner Sinitsa VV. 02.07.02; publ. March 17, 2003;3. [In Ukrainian].

Zeisler YuV, Artamonov IG. POVISEP - new in dentistry. Dentist. 2008;8:16–7.

Nagirny YaP, Hutor NS. Clinical effectiveness of polybiolin-curiosin mixture for the treatment of dry socket. Clinical dentistry. 2018;3:70–5. [In Ukrai­nian].

Petrukh LI. Certificate of Ukraine for the mark of goods and services № 24424. “Flurenizide”. Phar­maceutical and medical drugs used for humans and in veterinary medicine. application. 10.02.99; publ. 04/15/02;4. [In Ukrainian].

Nizelsky YuM. Flureniside - Ukrainian medi­cines of the XXI century. Bukovynian. Medical Bul­letin. 2002;6:1:192–3. [In Ukrainian].

Flurenizide – a new original Ukrainian drug with anti-TB and antimicrobial action. Register of industry innovations. Issue. Register 2001;87:14–5. [In Ukrainian].

Petrukh LI. Fluorenes as tuberculostatics. Flurenizide: micro-biological, pharmacological and clinical aspects. Lviv. 2008;463. [In Ukrainian].

Sibirna RI. Bacteriostatic activity of flurenizide against atypical mycobacteria. Microbiological Journal. 1994;56:1:98–9. [In Ukrainian].

Pat. 75600С2 Ukraine, MPK6 А61К 31/10, А61К 31/465, А61Р 31/02 Antiseptic. Petrukh LI, Mikhalyk OI.; applicant and patent owner Lviv National Medical University. Danylo Halytsky – № 2002129962 appli­cation. from 11.12.02; publ. 15.05.06;5. [In Ukrainian].

Pat. 82787С2 Ukraine, MPK6A 61 K 31/10, A 61 K 31/465, A 61 K 47/10, A 61 D 99/00, A 61 P 43/00. Application of pharmaceutical composition for the treatment of chronic otodectosis. Petrukh LI, Ostrov­skaya LL, Mikhalyk OI, Ostrovsky YaZ.; applicant and patent owner Petrukh Lyubov Ivanivna; Lviv National Medical University named after Danylo Halytsky – № а200613873; declared 26.12.06; publ. 12.05.08;9. [In Ukrainian].

Zhuraev R, Vynnyk-Zhuraeva I, Krystopchuk S, Patko J. The effectiveness of the solution “Flupetsal” in the complex treatment of reactive chlamydia-associated arthritis. 65th scientific conference. with international participation of students and young scientists 2004: thesis add. – Lviv, 2004;206–7. [In Ukrainian].




How to Cite

Hutor, N. S. (2022). CURRENT DIAGNOSIS, PREVENTION AND TREATMENT OF DRY SOCKET: (literature review). International Journal of Medicine and Medical Research, 7(2), 58–65.