BONE TISSUE METABOLISM AND CHANGES IN THE ORAL CAVITY IN REDUCED FUNCTIONAL ACTIVITY OF THE THYROID GLAND
(literature review)
DOI:
https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12426Keywords:
periodontitis, thyroid glandAbstract
Background. Decreased functional activity of the thyroid gland leaves affects many organs and systems as well as bone tissue, pathological changes of which in the oral cavity are most often observed in periodontitis. However, the relationship between thyroid hypofunction and periodontitis or other inflammatory diseases of the oral cavity is still not confirmed.
Objective. The aim of the review was to study the published information and analyse bone metabolism and its relationships between autoimmune thyroiditis and oral diseases.
Methods. The articles in foreign periodicals on endocrinology, pathophysiology, dental surgery and therapy were the scientific sources for research.
Results. Understanding the mechanisms of bone metabolism under the action of thyroid hormones is an important aspect of treatment and diagnostic process, as local treatment of dental pathology without reducing the impact on systemic factors ultimately does not have any positive result. Decreased functional activity of the thyroid gland leads to homeostasis imbalance in the body. The thyroid hormones are important for bone metabolism, publications on periodontitis incidence in cases of autoimmune pathology of the thyroid gland are the most common. However, despite the number of studies, most authors agree that they are currently insufficient to clearly establish a causal relationship between autoimmune thyroid disease and maxillofacial disorders.
Conclusions. The study expands our knowledge, but there is still a need for further detailed studies that would clearly define the mechanisms of development of the disorders of the oral bone tissues and its relationships with autoimmune pathology of the thyroid gland.
References
Kravchenko VI. Iodine deficiency as a cause of high prevalence of thyroid pathology in the population of regions affected by the chernobyl accident. Zhurnal NAMN Ukrainy. 2016;22(2):222-9 [in Ukrainian].
Chukur OO. Dynamics of morbidity and prevalence of thyroid pathology among the adult population of Ukraine. Bulletin of social hygiene and health care organization of Ukraine. 2018;4(78):19-25 [in Ukrainian].
Vladymyrova IM, Heorhiiants VA. Farmakoterapevtychni napriamky zastosuvannia yodovmisnykh likarskykh roslyn pry riznykh hrupakh zakhvoriuvan shchytopodibnoi zalozy [Pharmacotherapeutic directions of application of iodine-containing medicinal plants in different groups of diseases of the thyroid gland]. Scientific Journal “ScienceRise”. 2015;11/4 (16):46-54 [in Ukrainian].
Pankiv IV. Influence of the functional state of the thyroid gland on bone mineral density. Trauma. 2015;6(16):33-41 [in Ukrainian].
Kothiwale S, Panjwani V. Impact of thyroid hormone dysfunction on periodontal disease. J Sci Soc. 2016;43:34-47.
Aldulaijan HA, Cohen RE, Stellrecht E, Levine MJ. Relationship between hypothyroidism and periodontitis: A scoping review. Clin Exp Dent Res. 2020;6:147-57.
https://doi.org/10.1002/cre2.247
Patil B, Patil S, Gururaj T. Probable autoimmune causal relationship between periodontitis and Hashimotos thyroidits: A systemic review. Nigerian journal of clinical practice. 2011;14:253-61.
https://doi.org/10.4103/1119-3077.86763.
Allen MR, Burr DB. Bone Modeling and Remodeling. Basic and Applied Bone Biology 2014;Chapter 4:75-90.
Kenkre JS., Bassett J. The bone remodelling cycle. Ann Clin Biochem. 2014;55(3):308-27.
https://doi.org/10.1177/0004563218759371.
Siddiqui JA, Partridge NC. Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement. Physiology (Bethesda), May, 31 (3). 2016;233-45.
DOI:10.1152/physiol.00061.2014.
Martin TJ, Sims NA. RANKL/OPG; Critical role in bone physiology. Rev Endocr Metab Disord, Jun. 2015;16(2):131-9.
https://doi.org/10.1007/s11154-014-9308-6.
Walsh MC, Choi Y. Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond. Front Immunol. Oct 20; 5, 511. 2014.
https://doi.org/10.3389/fimmu.2014.00511.
Honma M, Ikebuchi Y, Suzuki H. Mechanisms of RANKL delivery to the osteoclast precursor cell surface. J Bone Miner Metab. 2021;Jan 39(1):27-33.
https://doi.org/10.1007/s00774-020-01157-3.
Kiyoi T. Bone Resorption Activity in Mature Osteoclasts. Methods Mol Biol. 2018;1868:215-22.
https://doi.org/10.1007/978-1-4939-8802-0_22.
Horwood NJ. Macrophage Polarization and Bone Formation: A review. Clin Rev Allergy Immunol. 2016;Aug;51(1):79-86.
https://doi.org/10.1007/s12016-015-8519-2.
Delaisse JM. The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation. Bonekey Rep. 2016;5:856.
https://doi.org/10.1038/bonekey.2016.88.
Kini U, Nandeesh BN. Physiology of Bone Formation, Remodelling, and Metabolism. In: Fogelman, I., Gnanasegaran, G. and Wall, H., Eds., Radionuclide and Hybrid Bone Imaging, Springer, Berlin, Heidelberg. 2012;29-57.
Nudelman F, Pieterse K, George A, Bomans PH, Friedrich H, Brylka LJ, Hilbers PA, de With G, Sommerdijk NA. The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors. Nat Mater, 2010;Dec;9(12):1004-9.
https://doi.org/10.1038/nmat2875.
Wu V, van Oers RFM, Schulten EAJM, Helder MN, Bacabac RG, Klein-Nulend, J. Osteocyte morphology and orientation in relation to strain in the jaw bone. Int J Oral Sci. 2018;Feb 26, 10(1):2.
https://doi.org/10.1038/s41368-017-0007-5.
Klein-Nulend J, Bakker AD, Bacabac RG, Vatsa A, Weinbaum S. Mechanosensation and transduction in osteocytes. Bone. 2013;54:182-190.
https://doi.org/10.1016/j.bone.2012.10.013.
Capulli N, Paone R, Rucci N. Osteoblast and osteocyte: Games ithout frontiers. Arch Biochem Biophys. 2014;Nov 1,561:3-12.
https://doi.org/10.1016/j.abb.2014.05.003.
Bizzaro G., Shoenfeld Y.Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. Immunol Res. 2015;61(1-2):46-52.
https://doi.org/10.1007/s12026-014-8579-z.
Gromova OA, Torshin IYU, Limanova OA. Mnogogrannaya rol’ makro- i mikroyelementov v postroyenii kostnoy tkani. Ginekologiya. 2014;2:50-6.
https://doi.org/10.26442/2079-5831_16.2.50-56.
Panʹkiv VI. Syndrom hipotyreozu. Mezhdunarodnyy éndokrynolohycheskyy zhurnal, 2012;5(45):136-48.
Polovina SP, Miljic D, Zivojinovic S, Milic N, Micic D, Brkic VP. The impact of thyroid autoimmunity (TPOAb) on bone density and fracture risk in postmenopausal women. Hormones (Athens, Greece), 2017;16(1):54-61.
https://doi.org/10.14310/horm.2002.1719.
Lee K, Lim S, Park H, Woo HY, Chang Y, Sung E, Jung HS, Yun KE, Kim CW, Ryu S, Kwon MJ. Subclinical thyroid dysfunction, bone mineral density, and osteoporosis in a middle-aged Korean population. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2020;31(3):547-55.
https://doi.org/10.1007/s00198-019-05205-1.
Baliram R, Latif R, Zaidi M, Davies TF. Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology. Front. Endocrinol. 2017;8:252.
https://doi.org/10.3389/fendo.2017.00252.
Bassett JH, Williams GR. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. Endocr Rev. 2016;37(2):135-87.
https://doi.org/10.1210/er.2015-1106.
Duncan Bassett JH, Williams GR. Analysis of Physiological Responses to Thyroid Hormones and Their Receptors in Bone. Methods in molecular biology (Clifton, N.J.). 2018;1801:123-54.
https://doi.org/10.1007/978-1-4939-7902-8_12.
Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG, Smith SA, Daniels GH, Cohen HD. American Thyroid Association guidelines for detection of thyroid dysfunction. Archives of internal medicine. 2020;160(11):1573-5.
https://doi.org/10.1001/archinte.160.11.1573.
Kosińska A, Syrenicz A, Kosiński B, Garanty-Bogacka B, Syrenicz M, Gromiak E. Osteoporoza w chorobach tarczycy. Endokrynol Pol. 2005;2:185-93.
Sheremet MI, Shidlovskiy VА, Sydorchuk LP. Autoimmune thyroiditis. Modern views on the pathogenesis and treatment (literature review). Endocrynologia. 2014;19(3):227-35. [in Ukrainian].
Mazur IP, Pavlenko OV. The current state of dental care in Ukraine Health of Ukraine. 2017;18 (415):74-5. [in Ukrainian].
Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. International journal of health sciences. 2017;11(2):72-80.
Borgnakke WS. Does Treatment of Periodontal Disease Influence Systemic Disease? Dental clinics of North America. 2015;59(4):885-917.
https://doi.org/10.1016/j.cden.2015.06.007.
Kowalski J, Górska R. Clinical and microbiological evaluation of biofilm-gingival interface classification in patients with generalized forms of periodontitis. Polish Journal of Microbiology. 2014;63(2):175-181.
Kang W, Hu Z, Ge S. Healthy and Inflamed Gingival Fibroblasts Differ in Their Inflammatory Response to Porphyromonas gingivalis Lipopolysaccharide. Inflammation. 2016;39(5):1842-52.
https://doi.org/10.1007/s10753-016-0421-4.
Onyshchenko VS, Ovcharenko OM, Trofymenko OA. Lazerna dopplerivsʹka floumetriya v otsintsi pokaznykiv mikrotsyrkulyatsiyi pry zakhvoryuvannyakh tkanyn parodontu na riznykh etapakh ortopedychnoho likuvannya // Materialy nauk.-prakt. konf. z mizhnar. uchastyu, XII zasidannya Ukrayinsʹkoho Dopplerivsʹkoho Klubu “Ulʹtrazvukova ta funktsionalʹna diahnostyka v anhiolohiyi”. 2006;46-8.
Lira-Junior R, Figueredo CM, Bouskela E, Fischer RG. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. Journal of periodontology. 2014;85(12):1648-57.
https://doi.org/10.1902/jop.2014.140189.
Zyul’kina LA, Sabayeva MN, Ivanov PV, Shastin YeN. Mikrotsirkulyatsiya tkaney parodonta: prichiny narusheniy i mekhanizmy korrektsii. Sovremennyye problemy nauki i obrazovaniya. 2017;2.
Scardina GA, Messina P. Modifications of interdental papilla microcirculation: a possible cause of periodontal disease in Hashimoto’s thyroiditis? Ann Anat. 2008;190(3):258-63.
https://doi.org/10.1016/j.aanat.2007.12.004.
Morais AМ, Pereira J. Hashimoto Thyroiditis and Periodontal Disease: A Narrative Review. Acta Médica Portuguesa. 2016;29(10):651-7.
https://doi.org/10.20344/amp.6704.
Bhankhar RR, Hungund S, Kambalyal P, Singh V, Jain K. Effect of nonsurgical periodontal therapy on thyroid stimulating hormone in hypothyroid patient with periodontal diseases. Indian J Dent Res. 2017;2:16-21.
https://doi.org/10.4103/ijdr.IJDR_174_16.
Rakhymov CHR. Likuvalʹno-profilaktychni osoblyvosti zakhvoryuvanʹ parodonta u khvorykh na hipotyreoz. Suchasna stomatolohiya. 2020;1:34-8.
https://doi.org/10.33295/1992-576X-2020-1-34.
Yussif NM, El-Mahdi FM, Wagih R. Hypothyrodism as a risk factor of periodontitis and its relation with vitamin D deficiency: mini-review of literature and a case report. Clin Cases Miner Bone Metab. 2017;14(3):312-6.
https://doi.org/10.11138/ccmbm/2017.14.3.312.
Bizzaro G, Shoenfeld Y. Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. Immunol Res. 2015;Feb;61(1-2):46-52.
https://doi.org/10.1007/s12026-014-8579-z.
Tuchendler D, Bolanowski M. The influence of thyroid dysfunction on bone. Thyroid Research. 2014;7:12.
https://doi.org/10.1186/s13044-014-0012-0.
Rahangdale SI, Galgali SR. Periodontal status of hypothyroid patients on thyroxine replacement therapy: A comparative cross-sectional study. J Indian Soc Periodontol. 2018;22(6):535-40.
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