MAIN INDICATORS OF THE OXIDANT-ANTIOXIDANT SYSTEM AND THEIR RELATIONSHIP WITH THE FORCE OF THE RESPIRATORY MUSCLES IN ADULT PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

Authors

DOI:

https://doi.org/10.11603/ijmmr.2413-6077.2021.1.12251

Keywords:

community-acquired pneumonia, respiratory muscles, oxidative-antioxidant system

Abstract

Background. Currently, pneumonia ranks 4-5 rate in the world in the structure of death causes after cardiovascular and cancer diseases, cerebrovascular pathology, injuries and poisonings.

Objective. The aim of the study was to evaluate the indicators of the oxidative-antioxidant system and their relationship with the strength of the respiratory muscles in adult patients with community-acquired pneumonia.

Methods. The study was carried out in the period 2017-2020 on the basis of the therapeutic department of the Municipal non-profit enterprise "City Clinical Multidisciplinary Hospital № 25" of Kharkiv City Council. The study involved 52 adult patients with CAP aged 18 to 80 years. The control group consisted of 20 apparently healthy humans. It was determinated the activity of malondialdehyde, catalase and superoxide dismutase, level of reduced glutathione, glutathione reductase and glutathione peroxidase. The assessment of the RM strength was investigated by recording the maximum static pressures at the level of the mouth and nose with “closed” airways using a MicroRPM apparatus on the 1st and 10th days of illness.

Results. Dysfunction of expiratory respiratory muscles prevailed in patients with non-severe CAP, and inspiratory respiratory muscles in patients with severe CAP. Were established significant negative correlations of malondialdehyde with indicators of respiratory muscles strength and positive correlations with glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase.

Conclusions. The presence of relationships between pro- and antioxidant indicators and respiratory muscles strength complements the concept of the body's systemic response on pulmonary inflammation – one of the markers of respiratory muscles dysfunction.

KEYWORDS: community-acquired pneumonia, respiratory muscles, oxidative-antioxidant system.

Author Biography

V. I. Bereznyakov, KHARKIV MEDICAL ACADEMY OF POSTGRADUATE EDUCATION, KHARKIV, UKRAINE

PhD, Associate Professor, Department of General Practice – Family Medicine, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

References

Avdeev SN, Chuchalin AG. [Severe community-acquired pneumonia]. Russian medical journal 2001; 5:177-181. (In Russian).

Lanks CW, Musani AI, Hsia DW. Community-acquired Pneumonia and Hospital-acquired Pneu­monia. Med Clin North Am 2019; 103(3): 487-501.

DOI: 10.1016/j.mcna.2018.12.008.

Prina E, Ranzani OT, Torres A. Community-acquired pneumonia. The Lancet 2015; 386(9998): 1097-1108.

DOI: 10.1016/S0140-6736(15)60733-4.

Wunderink RG, Waterer G. Advances in the causes and management of community acquired pneumonia in adults. BMJ 2017; 358: j2471.

DOI: 10.1136/bmj.j2471.

Eshwara VK, Mukhopadhyay C, Rello J. Community-acquired bacterial pneumonia in adults: An update. Indian J Med Res 2020; 151(4): 287-302.

DOI: 10.4103/ijmr.IJMR_1678_19.

Chuchalin AG, Sinopalnikov AI, Kozlov RS, Avdeev SN, Tyurin IE et al. [Diagnosis, treatment and prevention of severe community-acquired pneumo­nia in adults]. Pulmonology 2014; 4: 13-48. (In Russian).

Kolek V, Jakubec P, Losse S. Diagnostics and treatment of community-acquired pneumonia - simplicity is the key to success. Vnitr Lek 2018; 63(11): 770-775.

Ozlek E, Biteker FS, Cil C, Celik O et al. The risk stratification in community-acquired pneumonia. The American Journal of Emergency Medicine 2019; 37(1): 171.

DOI: https://doi.org/10.1016/j.ajem.2018.05.061

Jones B, Waterer G. Advances in community-acquired pneumonia. Therapeutic Advances in Infectious Disease 2020; 7: 1-11.

DOI: 10.1177/2049936120969607

Soodaeva SK, Klimanov IA, Nikitina LYu. [Nitrosative and oxidative stress in respiratory diseases]. Pulmonology 2017; 2(27): 262-273. (In Russian).

Demidchik LA, Muravleva LE, Molotova-Luchanskaya VB, Bakirova RE, Klyuev DA et al. [Characteristics of the oxidative metabolism of erythrocytes in patients with community-acquired pneumonia]. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences 2016; 3-2(109): 26-28. (In Russian).

Geltser BI, Kurpatov IG, Dey AA, Kozhanov AG. [Respiratory muscle dysfunction and respiratory diseases]. Therapeutic archive 2019; 91(3): 93-100. (In Russian).

Segizbaeva MO, Aleksandrova NP. [Asses­sment of the resistance of different groups of in­spiratory muscles to fatigue during exercise against the background of simulated airway obstruction]. Fiziol. person 2014; 40(6): 683-689. (In Russian).

Stalnaya ID. [Method for the determination of malonic dialdehyde using thiobarbituric acid. Modern methods in biochemistry]. Moscow: Me­dicine, 1977: 66-68. (In Russian).

Girin SV. [Modification of the method for determining the activity of catalase in biochemical substrates]. Lab. diagnostics 1999; 4: 45-46. (In Russian).

Saydam N, Kirb A, Demir O, Hazan E, Oto O, Saydam O, Güner G. Determination of glutathione, glutathione reductase, glutathione peroxidase and glutathione S-transferase levels in human lung cancer tissues. Cancer Lett. 1997; 119(1): 13-9.

DOI: 10.1016/s0304-3835(97)00245-0.

Kabitz HJ, Walterspacher S, Mellies U. et al. Recommendations for respiratory muscle testing. Pneumologie 2014; 68(5): 307-314.

DOI: 10.1055/s-0034-1365283

Lapach SN, Chubenko AV, Babich PN. [Statistical Methods in Biomedical Research Using Exel]. 2nd ed. K.: Morion, 2001; 408 p. (In Russian).

Somov DA, Makarova MR, Makarova IN. [The value of muscle imbalance for the development of therapeutic exercises in patients with pneumonia]. Questions of balneology, physiotherapy and physical therapy 2015; 3(92): 7-10. (In Russian).

Downloads

Published

2021-11-22

How to Cite

Bereznyakov, V. I. (2021). MAIN INDICATORS OF THE OXIDANT-ANTIOXIDANT SYSTEM AND THEIR RELATIONSHIP WITH THE FORCE OF THE RESPIRATORY MUSCLES IN ADULT PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA. International Journal of Medicine and Medical Research, 7(1), 35–41. https://doi.org/10.11603/ijmmr.2413-6077.2021.1.12251