A CROSS SECTIONAL STUDY OF LIPID PROFILE IN NON-DIABETICS WITH STROKE IN URBAN CHITRADURGA
DOI:
https://doi.org/10.11603/ijmmr.2413-6077.2021.1.12109Keywords:
lipid profile, dyslipidemia, non-diabetic stroke, serum cholesterolAbstract
Background. The amount of evidence regarding the relation between serum lipids, lipoproteins and cerebrovascular accident is not adequate. The atherogenecity of diabetics and non-diabetics are different. Therefore, non-diabetic patients were included in the study.
Objective. To study lipid abnormalities in non-diabetic stroke patients in our setup.
Methods. The study was carried out at the Department of General Medicine, BMCH, Chitradurga, during the period from June 2020 to December 2020. The lipid profile and the fasting blood sugar rates of 50 stroke patients without diabetes were studied. Their serum samples were assessed for fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) by using standard biochemical methods.
Results. The age distribution of the subjects was from 19 to 72 years with a mean age of patients 54.8±15.75 years. Among patients 31 (62%) were males and 19 (38%) were females. Among the study subjects 58% were hypertensive, 76% were smokers, 32% were alcoholics and 34% had family history of cerebrovascular accident. Among ischemic stroke group, the most common deranged value in the ischemic group was decreased HDL deranged in 54.1% of patients; the second most common deranged value – increased VLDL deranged in 40.5%. Among the hemorrhagic group the most common deranged value was also decreased HDL, which was deranged in 46.1% of patients and the second most common deranged value – increased total cholesterol, which was deranged in 53.8% patients.
Conclusion. Lipid profile should be considered while predicting the risk of stroke.
References
World Health Organization. The world health report 2002: reducing risks, promoting healthy life. World Health Organization; 2002.
Smith WS, Johnston SC, Hemphill III JC. Cerebrovascular Diseases. In: Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J eds. Harrison’s Principle of Internal Medicine. 20th ed. McGraw Hill; 2020:2559-86.
Kar A, Dash C, Murmu M, KP KM. Study of lipid profile in cases of non-diabetic stroke. International Journal of Advances in Medicine. 2018 Jan 18;5(1):82-90.
DOI: 10.18203/2349-3933.ijam20180063
Nigam PK. Serum lipid profile: fasting or non-fasting. Indian J Clin Biochem 2011;26(1):96-7.
DOI: 10.1007%2Fs12291-010-0095-x
Sreedhar K, Srikant B, Joshi L, Usha G. Lipid profile in non-diabetic stroke-a study of 100 cases. J Assoc Physicians India. 2010;58:547-51.
DOI: 10.18203/2349-3933.ijam20180063
Benfante R, Yano K, Hwang LJ, Curb JD, Kagan A, Ross W. Elevated serum cholesterol is a risk factor for both coronary heart disease and thromboembolic stroke in Hawaiian Japanese men. Implications of shared risk. Stroke. 1994;25(4):814-20.
DOI: 10.1161/01.STR.25.4.814
Dimascio R, Marchiolli R, Vituollo F, Dipasquale A, Cavasinni L, Tognoni G. Serum cholesterol and risk of ischemic stroke: results of a case-control study. Prev Med. 1995;24(2):128-33.
DOI: 10.1006/pmed.1995.1025
Iso H, Jacobs DR, Wentworth D, Neaton JD, Cohen JD, MRFIT Research Group. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N Engl J Med. 1989;320(14):904-10.
DOI: 10.1056/nejm198904063201405
Harmsen P, Rosengren A, Tsipogianni A, Wilhelmsen L. Risk factors for stroke in middle-aged men in Göteborg, Sweden. Stroke. 1990;21(2):223-9.
DOI: 10.1161/01.str.21.2.223
Rastenyte D, Tuomilehto J, Domarkiene S, Cepaitis Z, Reklaitiene R. Risk factors for death from stroke in middle-aged Lithuanian men. Stroke. 1996;27(4):672-6.
DOI: 10.1161/01.str.27.4.672
Hart CL, Hole DJ, Smith GD. Risk factors and 20-year stroke mortality in men and women in the Renfrew/Paisley study in Scotland. Stroke. 1999; 30(10):1999-2007.
DOI: 10.1161/01.str.30.10.1999
Tilvis RS Erkinjunti J ,Sulkava R et al.Serum lipids and fatty acids in ischemic stroke.American heart journal1987;113;615-619.
DOI: 10.1161/01.str.26.5.778
Farid N. R, Anderson. J: Cerebrovascular disease and hyper-lipoproteinemias. Lancet 1, 1398; 1972.
DOI: 10.1016/s0140-6736(72)91136-1
Hatchinski V Graffagnino C,Beaudry,Bernier G, Buck,Donner A, SpenceD,DoidG& WolfeBMF1996.Lipids and stroke a paradox resolved,Arch Neuro53; 303-308
AlbucherJF,Ferrieros J et al.serum lipids in young patients with ischemic stroke,a case control study.J Neurology Neurosurgery psychiatry 2000; 69(1);29-33.
DOI: 10.1136/jnnp.69.1.29
Simons LA, McCallum J, Friedlander Y, Simons J. Risk factors for ischemic stroke: Dubbo study of the Elderly. Stroke 1998;29:1341-1346.
DOI: 10.1161/01.str.29.7.1341
Alok mohankar, Ravindrakumar Garg et al.serum lipids and stroke.neurology India 1993.
Botet PJ, Senti M, Nogues X, Rubies-Prat J, Roquer J, D’Olhaberriague L et al. Lipoprotein and apolipoprotein profile in men with ischemic stroke: Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke 1992; 23:1556-62.
DOI: 10.1161/01.str.23.11.1556
Kurth T.Everett et al,Lipid levels and the risk of ischemic stroke in women.Neurology 2007;68;556-562.
DOI: 10.1212/01.wnl.0000254472.41810.0d
Bidyadhar S et al. Plasma lipids and lipoproteins in patients with premature IHD and ICD.Japi 1984;32;11.
DOI: 10.2337/diacare.27.6.1496
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 International Journal of Medicine and Medical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
