ANTI-INFLAMMATORY EFFECTS OF PROPOXAZEPAM ON DIFFERENT MODELS OF INFLAMMATION

  • N. Ya. Golovenko A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE https://orcid.org/0000-0003-1485-128X
  • T. A. Kabanova A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE
  • S. A. Andronati A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE https://orcid.org/0000-0001-8451-6327
  • O. I. Halimova A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE
  • V. B. Larionov A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE
  • A. S. Reder A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE https://orcid.org/0000-0002-1801-8378
Keywords: propoxazepam, diclofenac sodium, anti-inflammatory effect, carrageenan, formalin

Abstract

Background. Propoxazepam, 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin-2(3H)-one, is a promising analgesic and anticonvulsant and is on preclinical trial.

Objective. The aim of the research was to study the anti-inflammatory and analgesic action of Propoxazepam.

Methods. The anti-inflammatory action was evaluated by carrageenan induced rat paw edema, formalin-induced paw licking response in mice and bradykinin-induced pain response in rat models.

Results. It was established for the first time that the administration of Propoxazepam caused a significant anti-inflammatory activity when tested in different in vivo chemical experimental models of induced inflammation, i.e. carrageenan-, bradykinin- and formalin-induced inflammation tests.

Conclusions. Propoxazepam significantly reduced acute and sub-acute inflammation and proved its efficacy and similar to anti-inflammatory action.

Author Biographies

N. Ya. Golovenko, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., DSc, academician of National academy of Medical Sciences of Ukraine, Chief Researcher of laboratory of Physico-Chemical Pharmacology of Medicinal Chemistry Department, A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

T. A. Kabanova, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., Senior researcher of Medicinal Chemistry Department of A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

S. A. Andronati, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., Senior researcher of Medicinal Chemistry Department of A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

O. I. Halimova, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., Senior researcher of Medicinal Chemistry Department of A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

V. B. Larionov, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., DSc, Head of Laboratory of Physical-Chemical Pharmacology of Medicinal Chemistry Department of A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

A. S. Reder, A.V. BOGATSKY PHYSICO-CHEMICAL INSTITUTE OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE, ODESA, UKRAINE

Ph.D., Senior Researcher of A.V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odesa, Ukraine

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Published
2020-02-27
How to Cite
Golovenko, N. Y., Kabanova, T. A., Andronati, S. A., Halimova, O. I., Larionov, V. B., & Reder, A. S. (2020). ANTI-INFLAMMATORY EFFECTS OF PROPOXAZEPAM ON DIFFERENT MODELS OF INFLAMMATION. International Journal of Medicine and Medical Research, 5(2), 105-112. https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10900