systemic biomedicine, cardiovascular diseases, robustness of biological systems, emergence of systems, fundamental directions, conceptual aspects


Background. An attempt was made to link the basic conceptual approaches of systems biology: networking, modular thinking, emergence, as well as biological interaction limits and robustness with clinical medicine. With the help of these conceptual approaches, the growth of robustness (biological stability) and stability in the development of cardiac diseases has been explained.

Results. Possible pathways from modular activation to clinical phenotype are analyzed. It is postulated that systemic medical and systemic-biological studies are crucial for ensuring the success of efforts in the early diagnosis and personalized treatment of patients with cardiovascular pathology. They must prioritize and lead to the achievement of specific and realistic goals for strategies to intervene in the prevention of cardiovascular diseases. It is also shown that system-medical presentations provide a deeper understanding of which risk factors require the most attention, which drug-based approaches will be most effective and feasible in the context of limited time and cost resources.

Conclusions. Finally, it is concluded that the development of agreed key indicators is an important next step in system research. Alignment of key indicators will ensure effective monitoring of the course of coronary heart disease and an assessment of the dynamics of risk factors.


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How to Cite

Mintser, O. P., & Zaliskyi, V. M. (2019). СONCEPTUAL FRAMEWORK FOR THE APPLICATION OF SYSTEMIC BIOMEDICINE METHODOLOGY FOR THE ANALYSIS OF THE DEVELOPMENT OF CARDIOVASCULAR DISEASES. Medical Informatics and Engineering, (4), 29–40. https://doi.org/10.11603/mie.1996-1960.2018.4.9842