SOFTWARE FOR PHARMACOKINETIC SYSTEM RESEARCH

Authors

  • I. Ye. Andrushchak Volyn National University by Lesya Ukrainka

DOI:

https://doi.org/10.11603/mie.1996-1960.2009.3.94

Abstract

In this work there is fulfilled the analysis of software used for executing pharmacokinetic research. There are offered conceptual approaches in the form of informational models for development of web-integrated software environment including Java-classes library allowing to model basic ways of drugs injections

References

Menzel D.B. R.L. [et al.] Resources available for simulation in toxicology: specialized computers, generalized software and communication networks / D.B. Menzel, R.L. Wolpert, J.R. Boger, Drink Water and Health. - 1987. 8: - P. 229-254.

Burmaster D.E. Trivariate distribution for the height, weight, and fat of adult men / D.E. Burmaster, D.M.A. // Murray Risk Anal. 1998. Vol. 8. - P. 385-389.

Easterling M.R. Comparative analysis of software for physiologically based pharmacokinetic modeling: simulation, optimization, and sensitivity analysis / M.R. Easterling, M.V Evans, E.M. Kenyon // Toxicol. Methods. - 2000. - Vol. 10. - P. 203-229.

Reddy M.B. [et al]. Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise / M.B. Reddy, M.E. Andersen, P.E. Morrow // Toxicol. Sci. - 2003 - Vol. 72. - P. 3-18.

Blancato J.N. Physiologically based pharmacokinetic models. Examples of their use in exposure and risk assessment / J.N. Blancato, M.A. Saleh, C.H. Nauman, eds. In: Biomarkers of human exposure to pesticides. - Washington, DC: American Chemical Society. - 1994. - P. 264-283.

Haddad S., Pelekis M., Krishnan K. A methodology for solving physiologically based pharmacokinetic models without the use of simulation softwares // Toxicol. Lett. - 1996. 85. - P. 113-126.

Holmes S.L., Ward. R.C., Galambos J.D. [et al]. A method for optimization of pharmacokinetic models // Toxicol. Methods. 2000. - Vol. 10. - P. 41-53.

Clark L.H., Setzer R.W., Barton H.A. Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment // Risk Anal. - Vol. 24, .№ 6. - P. 16971717.

Hoang K.C.T. Physiologically based pharmacokinetic models-mathematical fundamentals and simulation implementations // Toxicol. Lett. - 1995. - Vol. 79. - P. 87-98.

Karba R., Zupancic B., Bremsak F. Simulation tools in pharmacokinetic modelling // Acta Pharm. Jugosl. - 1990. -Vol. 40. - P. 247-262.

Ramsey J.C., Andersen M.E. (1984) Aphysiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans // Toxicol. Appl. Pharmacol. - 1984. - Vol. 73.- P. 159-175.

Dong M.H. Microcomputer programs for physiologically-based pharmacokinetic (PB-PK) modelling // Comput. Methods Programs Biomed. - 1994. - Vol. 45. - P. 213-221.

Rey T.D., Havranek W.A. Some aspects of using the SimuSolv program for environmental, pharmacokinetics and toxicological applications // Ecological Modeling. - 1996. -Vol. 86. - P. 277-282.

Johanson G, Naslund P.H. Spreadsheet programming: a new approach in physiologically based modeling of solvent toxicokinetics // Toxicol. Lett. - 1988. - Vol. 41. - P. 115-127.

Ball R., Schwartz S.L. Cmatrix: software for physiologically based pharmacokinetic modeling using a symbolic matrix representation system // Comput. Biol. Med. - 1994. - Vol. 24.- P. 269-276.

Nichols J., Rheingans P., Lothenbach D. et al. Three-dimensional visualization of physiologically based kinetic model outputs // Environ. Health Perspect. - 1994. - Vol. 102.- P. 952-956.

Jonsson F., Johanson G. The Bayesian population approach to physiological toxicokinetic-toxicodynamic models-an example using the MCSim software // Toxicol. Lett. - 2003. - P. 143-150.

Минцер О.П. Биологическая и медицинская кибернетика: Справочник / Минцер О.П., Молотков В.Н., Угаров Б.Н. - К.: Наукова думка, 1989. - 375 с.

Марценюк В.П. Компартментний та перфузійний підходи до побудови моделей фармакокінетики / Марценюк В.П., Андрущак І. Є. // Медична інформатика та інженерія, .№3. - 2008. - С. 7-16.

Published

2012-11-12

How to Cite

Andrushchak, I. Y. (2012). SOFTWARE FOR PHARMACOKINETIC SYSTEM RESEARCH. Medical Informatics and Engineering, (3). https://doi.org/10.11603/mie.1996-1960.2009.3.94

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Articles