COURSE OF PREGNANCY, CHILDBIRTH, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF THE PLACENTA IN PREGNANT WOMEN WITH CORONAVIRUS DISEASE COVID-198
DOI:
https://doi.org/10.11603/mie.1996-1960.2022.3.13378Keywords:
pregnancy, COVID-19, complications of pregnancy, complications of childbirth, D-dimer, C-reactive protein, procalcitonin, blood plasmaAbstract
Background. The purpose of the study: to establish the complications of the course of pregnancy, childbirth, histological and immunohistochemical features of the placenta in women with the coronavirus disease COVID-19.
Material and methods. A comprehensive clinical examination of 65 pregnant women aged 22 to 34 years was conducted. Two groups were formed: the main group consisted of pregnant women who were diagnosed with COVID-19 during pregnancy; the comparison group was made up of pregnant women who did not have concomitant coronavirus disease during pregnancy.
Results. As a result of the study, it was established that women who were diagnosed with COVID-19 in the second and third trimesters of pregnancy had more frequent complications of pregnancy, which were manifested by fetal distress, uterine fibroids, hypohydramnios or polyhydramnios, VUI, compared to pregnant women who did not suffer from coronavirus the disease At the same time, in the group of patients with COVID-19, a higher percentage of premature births, fetal distress, chorioamnionitis, and acute respiratory distress syndrome of the fetus was observed, and a high percentage of operative deliveries was noted. At the same time, along with the development of the acute phase of inflammation, which is evidenced by an increase in the level of C-reactive protein (CRP), microthrombotic complications were observed, which was indicated by a high level of D-dimer in the blood plasma. An elevated procalcitonin level in pregnant women with COVID-19 indicates the presence of a localized infection.
Conclusions. Pregnancy and childbirth complications were more common in pregnant women with COVID-19 compared to pregnant women without coronavirus infection. Timely diagnosis of complicated pregnancy and childbirth using dopplerometry, biophysical profile of the fetus, determination of PSA, D-dimer, procalcitonin contributes to pathogenetic treatment and prevention negative perinatal consequences.
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