CHANGES IN THE MUCOSAL BARRIER IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
DOI:
https://doi.org/10.11603/mie.1996-1960.2022.3.13370Keywords:
mucosal barrier of the bowel, functional bowel disease, irritable bowel syndrome, tight junction, claudinAbstract
Background. The intestinal mucosal barrier may change under the influence of exogenous and endogenous factors. Changes in its physical and chemical characteristics are observed in patients with gastrointestinal diseases, such as irritable bowel syndrome, and with other pathologies, such as diabetes mellitus, food allergies, rheumatoid arthritis, etc. Also, the permeability of the intestinal wall was influenced by tight junctions, which are weakened due to eating disorders, psycho-emotional factors, and chemical agents. The purpose of the study was evaluating of changes in the mucosal barrier in patients with functional bowel diseases.
Materials and methods. 90 patients with different subtypes of irritable bowel syndrome were examined. Colonoscopy followed by a morphological assessment of biopsy specimens and immunohisto-chemical studies using markers of clau-din 1 and claudin 7.
Results. A decrease in the level of tight junction proteins called claudins was observed in patients with functional bowel disease. Patients with irritable bowel syndrome associated with diarrhea had a lower level of claudin-1 only, while patients with mixed form had also a lower level of claudin-7.
Conclusions. The pathogenesis of a violation of the protective function of the mucosa of functional and inflammatory bowel disease is different, which may determine approaches to the treatment of patients with such pathologies.
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