CHANGES IN THE MUCOSAL BARRIER IN PATIENTS WITH IRRITABLE BOWEL SYNDROME

Authors

DOI:

https://doi.org/10.11603/mie.1996-1960.2022.3.13370

Keywords:

mucosal barrier of the bowel, functional bowel disease, irritable bowel syndrome, tight junction, claudin

Abstract

Background. The intestinal mucosal barrier may change under the influence of exogenous and endogenous factors. Changes in its physical and chemical characteristics are observed in patients with gastrointestinal diseases, such as irritable bowel syndrome, and with other pathologies, such as diabetes mellitus, food allergies, rheumatoid arthritis, etc. Also, the permeability of the intestinal wall was influenced by tight junctions, which are weakened due to eating disorders, psycho-emotional factors, and chemical agents. The purpose of the study was evaluating of changes in the mucosal barrier in patients with functional bowel diseases.

Materials and methods. 90 patients with different subtypes of irritable bowel syndrome were examined. Colonoscopy followed by a morphological assessment of biopsy specimens and immunohisto-chemical studies using markers of clau-din 1 and claudin 7.

Results. A decrease in the level of tight junction proteins called claudins was observed in patients with functional bowel disease. Patients with irritable bowel syndrome associated with diarrhea had a lower level of claudin-1 only, while patients with mixed form had also a lower level of claudin-7.

Conclusions. The pathogenesis of a violation of the protective function of the mucosa of functional and inflammatory bowel disease is different, which may determine approaches to the treatment of patients with such pathologies.

References

Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M. R., Moraveji, S., Talmon, G., Rezaei, N., Hughes, P. A., Bian, Z. X., Choi, C. H., Lee, O. Y., Co§ffier, M., Chang, L., Ohman, L., Schmulson, M. J., McCallum, R. W., Simren, M., Sharkey, K. A., Barbara, G. (2018). Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30(1). DOI: 10.1111/nmo.13192. DOI: https://doi.org/10.1111/nmo.13192

Camilleri, M., Bueno, L., de Ponti, F., Fioramonti, J., Lydiard, R. B., Tack, J. (2006). Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders. Gastroenterology.130(5), 1421-1434. DOI: 10.1053/j.gastro. 2005.08.062. DOI: https://doi.org/10.1053/j.gastro.2005.08.062

Leech, B., Schloss, J., Steel, A. (2019). Treatment Interventions for the Management of Intestinal Permeability: A Cross-Sectional Survey of Complementary and Integrative Medicine Practitioners. Journal of alternative and complementary medicine (New York, N.Y.), 25(6), 623-636. DOI: 10.1089/ acm.2018.0374. DOI: https://doi.org/10.1089/acm.2018.0374

Farre, R., Vicario, M. (2017). Abnormal Barrier Function in Gastrointestinal Disorders. Handbook of experimental pharmacology. 239, 193-217. DOI: 10.1007/164_2016_107. DOI: https://doi.org/10.1007/164_2016_107

Zihni, C., Mills, C., Matter, K., Balda, M. S. (2016). Tight junctions: from simple barriers to multifunctional molecular gates. Nature reviews. Molecular cell biology. 17(9), 564-580. DOI: 10.1038/ nrm.2016.80. DOI: https://doi.org/10.1038/nrm.2016.80

Simren, M., Tack, J. (2018). New treatments and therapeutic targets for IBS and other functional bowel disorders. Nature reviews. Gastroenterology & hepatology. 15(10), 589-605. DOI: 10.1038/s41575-018-0034-5. DOI: https://doi.org/10.1038/s41575-018-0034-5

Enck, P., Mazurak, N. (2018). Dysbiosis in Functional Bowel Disorders. Annals of nutrition & metabolism. 72(4), 296-306. DOI: 10.1159/000488773. DOI: https://doi.org/10.1159/000488773

Tsukita, S., Tanaka, H., Tamura, A. (2019). The Claudins: From Tight Junctions to Biological Systems. Trends in biochemical sciences. 44(2), 141-152. DOI: 10.1016/j.tibs.2018.09.008. DOI: https://doi.org/10.1016/j.tibs.2018.09.008

Suzuki, T. (2020). Regulation of the intestinal barrier by nutrients: The role of tight junctions. Animal science journal = Nihon chikusan Gakkaiho. 91(1), e13357. DOI: 10.1111/asj.13357. DOI: https://doi.org/10.1111/asj.13357

Citi, S. (2019). The mechanobiology of tight junctions. Biophysical reviews. 11(5), 783-793. DOI: 10.1007/s12551-019-00582-7. DOI: https://doi.org/10.1007/s12551-019-00582-7

Lu, S., Singh, K., Mangray, S., Tavares, R., Noble, L., Resnick, M. B., Yakirevich, E. (2013). Claudin expression in high-grade invasive ductal carcinoma of the breast: correlation with the molecular subtype. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc. 26(4), 485-495. DOI: 10.1038/modpathol.2012.187. DOI: https://doi.org/10.1038/modpathol.2012.187

Shibutani, M., Noda, E., Maeda, K., Nagahara, H., Ohtani, H., Hirakawa, K. (2013). Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Anticancer research. 33(8), 33013306.

SQren, D., Yildirim, M., Kaya, V., Alikanoglu, A. S., BQlbQller, N., Yildiz, M., Sezer, C. (2014). Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma. Medical science monitor: international medical journal of experimental and clinical research. 20, 1255-1262. DOI: 10.12659/MSM.890598. DOI: https://doi.org/10.12659/MSM.890598

Kim, N. Y., Pyo, J. S., Kang, D. W., Yoo, S. M. (2019). Loss of claudin-1 expression induces epithelial-mesenchymal transition through nuclear factor-KB activation in colorectal cancer. Pathology, research and practice. 215(3), 580-585. DOI: 10.1016/j.prp.2019.01.015. DOI: https://doi.org/10.1016/j.prp.2019.01.015

Robles, A., Perez Ingles, D., Myneedu, K., Deoker, A., Sarosiek, I., Zuckerman, M. J., Schmulson, M. J., Bashashati, M. (2019). Mast cells are increased in the small intestinal mucosa of patients with irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 31(12), e13718. DOI: 10.1111/ nmo.13718. DOI: https://doi.org/10.1111/nmo.13718

Published

2023-05-26

How to Cite

Dorofeyev, A. E., Dyadyk О. О., & Prykhodko, V. M. (2023). CHANGES IN THE MUCOSAL BARRIER IN PATIENTS WITH IRRITABLE BOWEL SYNDROME. Medical Informatics and Engineering, (3), 24–29. https://doi.org/10.11603/mie.1996-1960.2022.3.13370

Issue

Section

Articles