SYSTEMS INTERACTION microRNAs IN PATHOGENESIS OF CARDIOVASCULAR DISEASES
DOI:
https://doi.org/10.11603/mie.1996-1960.2019.3.10428Keywords:
systems medicine, microRNAs (miRNAs), cardial hyperthrophy, fibrosis, apoptosis, cardiovascular disease, network, regulation.Abstract
Background. A review - analytical article is devoted to the analysis of the role of microRNAs (miRNAs) in modulating gene expression in biological events, primarily in cardiovascular diseases. Separate microRNAs are presented that have a systemic regulatory effect on the expression of target genes of processes such as myocardial hypertension, fibrosis, and apoptosis.
Purpose. The purpose of this review is to analyze the literature data on the regulatory effects of microRNAs in heart remodeling, in particular with myocardial hypertrophy, fibro-formation and apoptosis.
Results. Materials and methods. A group of miRNAs is analyzed, which may be of particular importance in the ontogenesis of cardiovascular diseases (CVD), since they modulate the expression of genes from target clusters, sites of many pathological cardiovascular reactions, the review illustrates the involvement of miRNAs in the network interaction of intracellular signaling pathways and positions important regulatory microRNA cooperation in CVD. It is postulated that the accumulated data on the role of miRNAs in the pathogenesis of diseases, primarily in the pathogenesis of cardiovascular diseases, are the basis for subsequent innovative solutions in the development of diagnostic methods and systemic therapy based on the use of post-translational regulators.
Conclusion. Circulating miRNAs can be proposed as promising diagnostic and prognostic biomarkers of CVDs, such as myocardial infarction, atherosclerosis, coronary heart disease, heart failure, etc.
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