Regularities of structural organisation of the heart myxomas in patients with Karney complex
DOI:
https://doi.org/10.61751/bmbr.2706-6290.2023.2.23Keywords:
benign tumours, morphology, mitral valve, Carney syndrome, light microscopyAbstract
Myxomas of the heart are one of the most common primary heart tumours, which most often develop in the
left atrium, are characterised by a benign nature and no relapses after surgical removal of the tumour. Karney complex
is an autosomal dominant disease characterised by numerous tumours, in particular, myxomas of the heart. Insufficient
coverage of this pathology in the literature leads to an erroneous diagnosis, progression of the disease and inadequate
treatment. The purpose of the study was to determine the morphological features of heart myxomas in patients with
Karney complex. Using light microscopy, a morphological examination of the heart myxomas was performed, which were
removed during 7 operations. Histological sections were made from the operating material, which were stained with
hematoxylin and eosin, according to Van Gieson, fuchselin, and Masson's Trichrome Stain in the Zerbino-Lukasevich
modification. A comparison of the group of heart myxomas of patients with the Karney complex (16 tumours) with a
group with myxomas of the heart that occur sporadically (278 tumours) was made to identify morphological features. It
was established that myxomas of the heart are multiple, they were detected with the same frequency in the right and left
chambers of the heart. It was generalised that in myxomas of the heart, signs of both alteration and high proliferative
activity of endotheliocytes and fibrous connective tissue cells are noted. Secondary myxomas of the heart in patients
with the Karney complex have the same structural organisation as primary tumours, but most often they are not relapses,
more often they are multiple and do not have a predominant localisation in the left atrium. The analysis established an
identical cellular composition of both groups of heart myxomas, which suggests the same source of tumour growth, but
the presence of more complex cell formations in sporadic myxomas and the predominance of single cells in Karney heart
myxomas indicate the existence of differences in their morphogenesis
Received: 28.02.2023| Revised: 15.05.2023| Accepted: 26.06.2023
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