ULTRASTRUCTURAL CHANGES OF PERIODONTAL COMPONENTS UNDER EXPERIMENTAL PERIODONTITIS COMBINED WITH HYPERTHYROIDISM
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2019.2.10611Keywords:
periodontitis, hyperthyroidism, periodontium, ultrastructural changesAbstract
The aim of the work. To investigate the ultrastructural changes of periodontium in experimental periodontitis combined with hyperthyroidism.
Materials and Methods. Studies were conducted on 36 outbred mature white male rats, which were divided into the following groups: I – control animals; II – animals with periodontitis; III – rats with periodontitis and hyperthyroidism. Periodontal tissues were examined by electronic microscopic examination on the day 22 of the experiment.
Results and Discussion. Ultrastructural studies of the periodontal components of rats in periodontitis demonstrated the reorganization of its structural elements. Affected microcirculation led to edema of the basic substance of the gums and periodontium, and also changes in the ultrastructure of cellular elements and damage of fibrous structures were found. Submicroscopic studies of the periodontal components of rats in periodontitis with underlying hyperthyroidism showed more pronounced destructive-degenerative and inflammatory changes of the epithelial and deep mucosa in all areas of the gums and periodontitis; damage of the nuclei and cytoplasm of keratinocytes, fibroblasts, leukocytes, fragmentation and lysis of fibers, swelling of the amorphous component were also observed.
Conclusions. Experimental periodontitis combined with hyperthyroidism is accompanied by more marked destructive-degenerative and inflammatory changes of periodontal tissues comparing with periodontitis without concomitant pathology that indicates a negative effect of thyroid dysfunction on the periodontitis.
References
Ohiienko SA, Piuryk VP, Popadynets OH. [Ultrastructural state of the periodontium in improvement of flap surgery in the treatment of patients with generalized periodontitis]. Klin stomat. 2017;4: 11-21. Ukrainian.
Biloklytska HF, Kopchak OV. [A new approach to the complex treatment of generalized periodontitis associated with cardiovascular pathology]. Visn stomat. 2017;4: 30-5. Ukrainian.
Pavlenkova E, Pavlenko S, Tkachenko I, Sidorova A. [Clinical and laboratory justification for the use of the drug based on the antiseptic Troklosene for the treatment of patients with chronic generalized periodontitis II and III severity]. Wiad Lek. 2018;71(4): 855-60. Russian. DOI: https://doi.org/10.29254/2077-4214-2018-4-1-146-28-31
Tomilina TV. [The development of dysbiosis in periodontal rats after splenectomy]. Journal of Health Sciences. 2014;04(01): 125-34. Russian.
Shcherba VV, Korda MM. [Peculiarities of the microbiocenosis of the oral cavity in animals with periodontitis on aphid hypertension and hypothyroidism]. Klin stomat. 2019;2: 65-71. Ukrainian.
Schneider SA. [Morphogenesis of experimental chronic periodontitis]. Morfolohiia. 2011;V(1): 38-41. Ukrainian.
Moyseeva EH. Metabolic homeostasis and immune reactivity of the body in the dynamics of inflammation in periodontal tissues. [Метаболический гомеостаз и имунная реактивность организма в динамике воспаления в тканях пародонта: экспериментальное исследование] Moscow: Russian University of People’s Friendship; 2008. Russian.
Ratushnenko VO. [Functional role of thiol-disulphide system in experimental hypo- and hyperthyroidism.]. Odes med zhurn. 2010; 2(118): 17-20. Ukrainian.
European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of Europe. Strasbourg; 1986.
Horalskyi LP, Khomych VT, Kononskyi OI. Basics of histological technique and morphofunctional methods of research in normal and pathology. [Основи гістологічної техніки і морфофункціогальні методи досліджень у нормі та при патолоії] Zhytomyr: Polissia; 2011. Ukainian.
Kopchak OV, Biloklytska HF, Stechenko LO, Kryvosheieva OI. [Periodontal ultrastructure in complex treatment of generalized periodontitis in patients with cardiovascular disease under conditions of PRP]. Visn prob biol i med. 2017;3(2): 179-88. Ukainian.
Kolesnik KA. [Pathogenetic approaches to the complex treatment of dentofacial anomalies in children with diffuse non-toxic goiter]. Extended abstract of Doctor’s thesis. Simferopol; 2014. Russian.
Sutaeva T.R. [Clinical and therapeutic features of periodontitis in patients with functional thyroid disorders]: Extended abstract of Doctor’s thesis. Moscow: 2010. Russian.
Bassett JH, van der Spek A, Logan JG. Thyrostimulin regulates osteoblastic bone formation during early skeletal development. Endocrinology. 2015; 156(9): 3098-113. DOI: https://doi.org/10.1210/en.2014-1943
Zahid ТМ, Wang BY, Cohen RE. The effects of thyroid hormone abnormalities on periodontal disease status. J Int Acad Periodontol. 2011;13(3): 80-5.
Iakovou I, Goulis DG, Tsinaslanidou Z, Giannoula E, Katsikaki G, Konstantinidis I. Effect of recombinant human thyroid-stimulating hormone or levothyroxine withdrawal on salivary gland dysfunction after radioactive iodine administration for thyroid remnant ablation. Head Neck. 2014;23: 23974.
Sutayeva TR, Minkailova SR, Shamov IM, Omarov OG. [Chronic generalized periodontitis in patients with endemic goiter]. Vest nov med tekhnol. 2012;19(3): 46-7. Russian.
Moskvina TS, Ivanova LI, Kaplin VN. [The state of periodontal and nonspecific resistance in the dynamics of experimental hypo- and hyperthyroidism]. Stamatologiya. 1993;3: 4-7. Russian.
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Accepted 2019-12-18
Published 2020-01-31
