Coronary heart disease and dynamics of intracardiac haemodynamics after hospitalisation for COVID-19: Results of a 12-month follow-up study
DOI:
https://doi.org/10.63341/bmbr/4.2024.23Keywords:
heart failure, inflammatory process, myocardial recovery, functional heart disorders, cardiac markersAbstract
The study aimed to evaluate the dynamics of intracardiac haemodynamics in patients with coronary heart
disease (CHD) after COVID-19 over 12 months. To achieve this goal, patients with COVID-19 and diagnosed with CHD
were monitored at the clinical sites of the Bogomolets National Medical University and the cardiology department of the
Road Clinical Hospital No. 2, Kyiv Clinical Hospital No. 18, and the Medbud Medical Centre. The main parameters studied
were left ventricular ejection fraction (LVEF), end-diastolic volume (EDV), cardiac output, troponins I and T, natriuretic
peptide, and C-reactive protein levels. The study determined that LVEF decreased to 47% in the 3rd month after COVID-19
and partially recovered to 52% in 12 months, but did not reach the control values. The EDV increased to 160 ml at month
3 and then decreased to 147 ml at month 12, indicating a volume overload of the left ventricle. Cardiac output at the
beginning of the study was 3.8 l/min, and at the end – 4.3 l/min, which indicated positive dynamics, but incomplete
recovery. The levels of troponins and natriuretic peptide were initially elevated, but gradually decreased to normal levels,
indicating the recovery of cardiac function. The elevated level of C-reactive protein recorded at the beginning of the study
indicated the presence of an active inflammatory process, which gradually decreased to normal values over 12 months.
This is a substantial indicator of inflammation reduction and improvement of the general condition of patients after
COVID-19. The results of the study indicated a partial recovery of heart function in patients but also demonstrated that
the recovery process is long and does not always result in a complete return to normal cardiac function
Received: 10.08.2024 | Revised: 28.10.2024 | Accepted: 26.11.2024
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