Morphometric aspects of studying the features of age structural reconstruction of the walls of the prostate arteries

Abstract

Summary. Age structural changes in the organ artery to date are the subject of study for morphologists and clinicians. At the same time, the age features of remodeling of the prostate arteries remain poorly understood.

The aim of the study – morphometric study of the features of age structural reconstruction of the prostate artery wall.

Materials and Methods. Morphometrically studied the structural age reconstruction of the prostate artery wall of 45 white rats, which were divided into 2 groups. Group 1 consisted of 15 animals aged 6 months, group 2 – 30 rats aged 24 months. Euthanasia of animals was performed by bloodletting under conditions of thiopental anesthesia. Histological micropreparations were made from the prostate gland, which morphometrically determined the outer and inner diameters, intima thicknesses, media, adventitia, intimo-medial, intimo-adventitia, adventitial-medial indices of arteries of small and medium calibers, relative volumes of damage endotheliocytes. Quantitative morphological parameters were processed statistically.

Results. The age structural reorganization of the arterial walls of the prostate gland, which was characterized by an increase in the thickness of the media, adventitia, atrophy of the intima, violation of the relationship between their morphometric parameters, increasing the number of damaged endothelial cells. The detected structural changes dominated in the arteries of small caliber of the studied organ, which play a major role in ensuring blood supply to the studied organ. The increase in the relative volume of damaged endothelial cells in the arterial bed of the prostate in laboratory white male rats was mainly due to apoptotically altered endotheliocytes, the number of which increases with age.

Conclusions. With age, morphological changes in the walls of the prostate arteries of laboratory adult white male rats are characterized by their thickening, narrowing of the lumen, atrophic processes in the intima, increasing thickness of the media and adventitia, disruption of relations between them, increasing the relative volume of damaged endoteliocytes. The severity of age-related structural changes in the walls of the arterial bed of the prostate dominates in the arteries of small caliber.