Morphological features of liver injury in COVID-19 according to data of own histological and literary research

Authors

  • D. O. Koshovska I. Horbachevsky Ternopil National Medical University
  • I. R. Okhotnytska I. Horbachevsky Ternopil National Medical University
  • K. M. Kovalchuk I. Horbachevsky Ternopil National Medical University
  • A. O. Stelmach I. Horbachevsky Ternopil National Medical University
  • T. K. Holovata I. Horbachevsky Ternopil National Medical University
  • A. Z. Mykolenko I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/bmbr.2706-6290.2021.4.12777

Keywords:

COVID-19, liver damage, hepatocytes steatosis

Abstract

Summary. SARS-CoV-2 infection is highly pathogenic and tropic to tissues of various internal organs. Severe course of COVID-19 is often accompanied by multiple organ failure, including liver damage. Therefore, the study of the morphogenesis features of liver tissue is an urgent task, because hepatocyte dysfunction is registered with a high frequency and the severity of the disease is associated with the degree of liver damage.

The aim of the study – to investigate the pathomorphological features of liver damage in COVID-19.

Materials and Methods. Scientific literature and histological studies of liver tissues of 4 patients, who died from complications of SARS-CoV-2 infection in hospitals of Ternopil region, were analyzed.

Results. It was prooved, that severe course of SARS-CoV-2 infection is accompanied by multiple organ failure, including dystrophic, inflammatory and ischemic liver damage.

Conclusion. Liver damage in severe course of COVID-19 manifests as significant macrovesicular steatosis, hepatocyte necrosis, lymphomacrophage infiltration of the portal tracts, and venous plethora in the vascular bed. These changes are the result of multiorgan inflammation, hypoxia, systemic inflammatory reactions, comorbidities that cause liver dysfunction and hepatotoxic effects of certain drugs.

References

Cao, X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20: 269-70. Available from: https://doi.org/10.1038/s41577-020-0308-3

Arno R Bourgonje, Amaal E Abdulle, Wim Timens, Jan-Luuk Hillebrands, Gerjan J Navis, Sanne J Gordijn et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol 2020; 251(3): 228-48. Available from: https://doi.org/10.1002/path.5471

Hoffman M. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020. Available from: https://doi.org/10.1016/j.cell.2020.02.052

Sufang Tian, Yong Xiong, Huan Liu, Li Niu, Jianchun Guo, Meiyan Liao et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Pathol. 2020;33(6): 1007-14. Available from: https://doi.org/10.1038/s41379-020-0536-x

Komisarenko SV. [Hunting of scientists for coronavirus SARS-COV-2, which causes COVID-19: scientific strategies for overcoming the pandemic]. Visn NAN Ukrainy. 2020;8: 29-71. Available from: https://doi.org/10.15407/visn2020.08.029. Ukrainian.

Fadieienko GD, Nikiforova YaV. [Tropism COVID-19 to the digestive system. Features of the lesion and approaches to treatment]. Such hastroenterol. 2020; 4(114): 65-72. Available from: https://doi.org/10.30978/MG-2020-4-65. Ukrainian.

Downloads

Published

2022-02-23

How to Cite

Koshovska, D. O., Okhotnytska, I. R., Kovalchuk, K. M., Stelmach, A. O., Holovata, T. K., & Mykolenko, A. Z. (2022). Morphological features of liver injury in COVID-19 according to data of own histological and literary research. Bulletin of Medical and Biological Research, (4), 182–185. https://doi.org/10.11603/bmbr.2706-6290.2021.4.12777

Issue

No. 4 (2021): Bulletin of Medical and Biological Research

Section

Short reports

License

Copyright (c) 2022 Bulletin of Medical and Biological Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.