Investigation and monitoring of immunosupressive status in patients with rheumatoid arthritis

Authors

  • O. I. Zarydna І. Horbachevsky Ternopil National Medical University
  • A. A. Hont І. Horbachevsky Ternopil National Medical University
  • D. O. Zarudna І. Horbachevsky Ternopil National Medical University
  • S. V. Danchak І. Horbachevsky Ternopil National Medical University
  • Y. Y. Yelisieiev І. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/bmbr.2706-6290.2021.4.12758

Keywords:

rheumatoid arthritis, immunosuppressive status, questionnaire

Abstract

Summary. The article presents the results of a study of the immunosuppressive status in patients with rheumatoid arthritis to assess the safety of standard treatment regimens for this disease.

The aim of the study – to assess the impact of standard RA treatment of patients' immune status and safety using diagnostic screening methods and questionnaires.

Materials and Methods. The treatment programs of 65 patients diagnosed with RA were evaluated. Screening diagnostic methods were used: determination of the total number of leukocytes and blood lymphocytes. Patients were also offered questionnaires to assess the frequency of infectious processes.

Results. To study the phenomenon of controlled immunosuppression in RA patients, they were divided according to their immunosuppressive status:  50 – those with immunosuppressive status, 8 – with low immunosuppressive status and 7 with indeterminate status. The number of leukocytes and lymphocytes  in these groups was determined. It was determined that no result goes beyond the normal ranges.  It was found that the number of leukocytes was even higher in patients with immunosuppressive status,  but lymphocytes were significantly lower compared to patients who did not receive immunosuppressive agents during  the study. Qualitative analysis of questionters and medical records revealed that patients with immunosuppressive status showed an infections  20 % more often than patients with low immunosuppressive status.

Conclusions. The assessment of white blood cell and lymphocyte counts, as a screening method, did not reveal significant abnormalities in RA with immunosuppressive therapy. However, a more detailed analysis of the group according to the status revealed that besides sufficient number of leukocytes in patients with immunosuppressive state, they have a significant decrease in the number of lymphocytes. Qualitative study of the questioneers and medical records revealed a higher ratio of infectious process in patients with RA and immunosuppressive status than in cases with low immunosuppressive status.

References

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Published

2022-02-23

How to Cite

Zarydna, O. I., Hont, A. A., Zarudna, D. O., Danchak, S. V., & Yelisieiev, Y. Y. (2022). Investigation and monitoring of immunosupressive status in patients with rheumatoid arthritis. Bulletin of Medical and Biological Research, (4), 41–45. https://doi.org/10.11603/bmbr.2706-6290.2021.4.12758

Issue

No. 4 (2021): Bulletin of Medical and Biological Research

Section

Original research

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