Quantitative morphological evaluation of age remodeling of the venous bed of the prostate

Abstract

Summary. It is known that the venous bed plays an important role in the drainage of venous blood from organs. When this function is impaired, venous plethora develops in the organs, which is complicated by hypoxia, dystrophy and necrobiosis of cells and tissues. It should be noted that age-related structural changes in the venous bed of the prostate have not been studied enough.

The aim of the study – quantitative morphological methods to study the features of age-related remodeling of the venous bed of the prostate.

Materials and Methods. A set of morphological methods studied the venous bed of the prostate gland of 40 laboratory white male rats, which were divided into 2 groups. Group 1 consisted of 20 intact almost healthy animals aged 8 months, group 2 – 20 white rats, aged 24 months. Euthanasia of animals was performed by bloodletting under conditions of thiopental anesthesia. Histological micronutrients were made of the prostate gland, which determined the diameter of capillary venules, venules, external and internal, wall thickness of venous vessels, height of endothelial cells, diameters of their nuclei, nuclear-cytoplasmic ratios in these cells, relative volumes of damaged endotheliocytes. Quantitative indicators were processed statistically.

Results. It was morphometrically established that with age the diameter of capillary venules of the prostate increased by 7.4 %, venules – by 6.7 %, outer diameter of venous vessels – by 5.8 %, inner – by 11.9 %, the relative volume of damaged endotheliocytes – 2 times the thickness of the vein wall decreased – by 8.5 %, the height of endotheliocytes – by 3.9 %, their nuclei – by 4.3 %. Microvascular density and nuclear-cytoplasmic ratios in endothelial cells did not change, indicating age-related stability of tissue and cellular structural homeostasis.

Conclusions. Age-related structural reconstruction of the venous bed of the prostate in laboratory white rats is characterized by dilation of the venous bed of the hemomicrocirculatory tract, venous vessels, reduction of their wall thickness, atrophy of endotheliocytes, increase in the relative volume of damaged endothelial cells. The degree of age structural reconstruction of the venous bed of the prostate dominates in the capillary venules and venules.