MORPHOMETRIC ASPECTS OF THE ANALYSIS OF AGE-RELATED STRUCTURAL CHANGES OF THE URETHRAL ARTERIES
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2021.3.12561Keywords:
urethra, arteries, morphometryAbstract
Summary. The study of angioarchitectonics of the intraorganic vascular bed in the organs at normal and in various pathological conditions is constantly in the field of interest of scientists. The variety of age-related vascular reactions of the urethra remain contradictory.
The aim of the study – morphometric research of age-related structural changes in the urethral arteries.
Material and Methods. The arteries of the urethra of 15 male Vietnamsese pigs, which were divided into 2 groups, were morphologically studied. Group 1 counted 8 intact practically healthy animals aged 3.5–4 months, group 2 – 7 intact pigs aged 6.5–7 months. Histological micronutrients were made from the urethra. Morphometry of urethral arteries was performed and their outer and inner diameters, media and adventitial thicknesses, endotheliocyte height, nucleus diameter, Wagenworth index, nuclear cytoplasmic ratio in endotheliocytes and relative volume of damaged endotheliocytes were measured. Quantitative indicators were processed statistically.
Results. The morphometric parameters of arteries of small caliber of the urethra changed significantly with age. The outer diameter of the studied vessels increased by 0.6 %, the thickness of the media – by 9.8 %, the Wagenworth index – by 21.9 %, the thickness of the adventitia – by 35.2 % (p <0.001). The inner diameter of small caliber arteries decreased by 9.3 % (p<0.001). The detected indicated an age-related decrease of capacity of the urethral arteries and deterioration of its blood supply. With age, atrophic and apoptotic changes in endothelial cells occur at stability of cellular structural homeostasis.
Conclusions. Age-related structural rearrangement of ureteral arteries in experimental animals is characterized by thickening of their wall, increasing media thickness, adventitia, Wagenworth index, narrowing of their lumen, reduced capacity of the studied vessels and deterioration of blood supply of organ. With age, the height of endotheliocytes decreases, the diameters of their nuclei increase, and the relative volume of damaged endotheliocytes increases with the stability of cellular structural homeostasis. The degree of age-related remodeling of the studied vessels dominates in the arteries of small urethral caliber.
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