STUDY OF CHANGES OF SKIN REPARATIVE ABILITY OF POSTOPERATIVE WOUNDS IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES

Abstract

Summary. Diabetes mellitus (DM) is recognized as one of the most important non-contagious diseases worldwide. Diabetes mellitus and its complications are one of the most important causes of death, and one of the important consequences of diabetes is impaired ability to repair.

The aim of the study – to identify changes in the reparative ability of the skin in rats with streptozotocin-induced diabetes, where different ways of closing postoperative wounds were used.

Materials and Methods. Experimental studies were performed on 130 white outbred adult male rats, which were divided into 4 groups: Group I (30 rats) – healthy, nodal sutures were used for the wound closure; Group II (30 rats) – healthy, skin glue was used for the wound closure; Group III (30 rats) – with diabetes mellitus, nodal sutures were used for the wound closure; Group IV (30 rats) – with diabetes mellitus, skin glue was used for the wound closure. For control, all the results were compared with those of intact animals (10 rats).

Results. Our research proves that the wound process leads to a decrease in the reparative ability of the skin at an early stage of observation. In the long-term follow-up, the reparative ability of the dermis in healthy groups of rats restore in contrast to groups of rats with streptozotocin diabetes.

Conclusion. The results show a decrease of the reparative ability of the skin, caused by wound healing in rats with experimental diabetic and in healthy rats where skin glue was used for the wound closure. However, the use of skin glue is more effective for the formation of normal scar in rats with diabetes, compared with the imposition of nodal sutures for the wound closure.