LIVER REMODELING IN POLYORGANIC INSUFFICIENCY SYNDROME
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.4.11826Keywords:
polyorganic insufficiency, acute respiratory distress syndrome, liver, remodelingAbstract
Summary. The basic principles of treatment of acute lung injury syndrome remain symptomatic and are aimed primarily at maintaining and normalizing oxygenation and eliminating the causes underlying acute lung injury. In the modern literature insufficient attention is paid to the correction of morphofunctional damage of the heart, kidneys and liver.
The aim of the study – to analyze the literature on the features of liver remodeling in polyorganic insufficiency syndrome.
Materials and Methods. The study looked at scientific publications over the last decade that are available on the Internet, with the keywords "polyorganic insufficiency syndrome", "liver remodeling".
Results. Summarizing the analysis of literature sources, we can talk about progress in the study of the field of organ failure in ARDS, improvement of terms and concepts, although to this day in scientific sources there are debatable data. Many modern studies relate to the features of compensatory-adaptive, detoxication and metabolic processes and the relationship between the morphometric parameters of the hepatic veins and liver lobes in the field of organ failure in ARDS.
Conclusions. Analytical review of the main trends of scientific research indicates an important place in the pathogenesis of polyorganic insufficiency syndrome structural changes of the liver as a central organ, which has a leading role in ensuring, at the level of stromal-parenchymal relationships, compensatory-adaptive, detoxification and metabolic processes. This justifies the need for further expand and deepen the understanding of the main structural changes that develop in this syndrome.
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