THE EFFECT OF CHRONIC ETHANOL INTOXICATION ON THE REPRODUCTIVE SYSTEM
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.3.11527Keywords:
ethanol, biological membranes, enzymes, angiopathyAbstract
Summary. Alcoholism is one of the most serious medical and social significant problems. The scale and rate of spread of alcoholism threaten physical and mental health. An important problem is the effect of excessive ethanol consumption on the reproductive system. A number of studies emphasize that alcohol is one of the main factors in male and female infertility.
The aim of the study – to analyze the current domestic and foreign literature on the effects of chronic ethanol intoxication on the reproductive system.
Materials and Methods. The material for the work was the data from literature about the problem of chronic effects of ethanol on the body to clarify current trends and views on the causal factors in the development of pathology of the reproductive system.
Results. The analysis of the literature suggests that chronic alcohol intoxication adversely affects almost all organs and systems of humans and experimental animals. Possessing a powerful membrane-tropic effect, ethanol and its metabolites lead to a sharp increase in the permeability of the microcirculatory tract, severe disorders of protein, lipid, carbohydrate metabolism, endocrinological and immunological changes. With the systemic nature of the lesion, due to chronic ethanol intoxication at a certain stage dominated pathology of one of the target organs, although a combination of injuries is possible, and their severity does not always correlate with the stage of chronic alcoholism.
Conclusions. In recent years, knowledge about the pathological effects of chronic alcohol intoxication on the organs and systems of the body has significantly expanded. A number of researchers report that alcohol is a major factor in male and female infertility. However, there is no complex morphological and pathophysiological substantiation of changes in male and female organs of reproductive system, which requires further detailed study.
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