REGENERATIVE MODULATION OF CARBOHYDRATE METABOLISM AND INCRETORY ACTIVITY OF Β-CELLS OF THE PANCREAS
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.2.11382Keywords:
type 2 diabetes mellitus, glycosylated hemoglobin, C-peptide, cell therapyAbstract
Summary. The acuteness of the problem of carbohydrate metabolism disorders – metabolic syndrome and diabetes mellitus – does not require evidence. Epidemiological data on these diseases, disability and premature mortality are very eloquent. Simultaneously, the issues of rational compensation of carbohydrate metabolism disorders and the inextricably linked with it restoration of the incretory activity of the pancreas remain relevant.
The aim of the study – in order to determine the effectiveness of treatment, the content of glycosylated hemoglobin (HbA1c) and C-peptide was analyzed in patients with type 2 diabetes mellitus who received traditional antidiabetic therapy before admission to the clinic and were under dispensary supervision at the place of residence.
Materials and Methods. At the clinic "MC" Institute of Family Medicine Plus" patients underwent comprehensive treatment, which included: correction of antidiabetic therapy, detoxification, pathogenetic physiotherapy and regenerative therapy: intravenous infusion of multipotent mesenchymal stem cells and subcutaneous injections of placenta extract. Before and after treatment, a comprehensive examination was performed, which included, in addition to general clinical and biochemical analyzes, a study of the carbohydrate metabolism panel, with the determination of HbA1c and C-peptide.
Results. Using of mesenchymal stem cells can not only increase the effectiveness of the type 2 diabetes treatment with traditional means and techniques, but sometimes allows completely abandon them. Stem cells restore the sensitivity of human tissues and cells to insulin action; significantly improve the function of the pancreas, which leads to the normalization of blood sugar levels.
Conclusions. The data obtained after re-examination of patients, conducted 3 months after treatment, indicate the prospects for the using of cell therapy as a pathogenetic method of compensating for carbohydrate metabolism disorders and preventing complications of diabetes.
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