RESPONSE OF THE REDOX SYSTEM TO THE EFFECT OF VARIOUS DRUGS FOR ANESTHESIA UNDER EXPERIMENTAL HYPERTHYROIDISM
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.3.11298Keywords:
free radical oxidation, antioxidant enzymes, hyperthyroidism, sodium thiopental, dexmedetomedineAbstract
Summary. The peculiarities of the processes of the redox system on the action of various drugs for anesthesia under conditions of hyperthyroidism in the experiment were studied. It was found that in experimental hyperthyroidism the intensity of free radical oxidation on the background of various drugs for anesthesia is more active than in euthyroidism and is accompanied by depletion of enzymes of the antioxidant system (catalase, reduced glutathione, glutathione peroxidase, superoxiddysmutase).
The aim of the study – to find out the peculiarities of the reaction of the redox system of experimental animals under the conditions of simulated hyperthyroidism to the action of various drugs for anesthesia.
Materials and Methods. Rats were injected with L-thyroxine for 21 days to simulate the state of hyperthyroidism. We compared the effect of euthyroidism and hyperthyroidism on the state of the redox system on the introduction of sodium thiopental and dexmedetomedine in the experiment.
Results. In the plasma of animals with experimental hyperthyroidism, an increase in the level of TBA-active products (initial and final products of free radical oxidation of lipids) and a significant difference in the effect of sodium thiopental and dexmedetomedine hydrochloride on the activity of antioxidant enzymes under hyper- and hyporthyroidism.
Conclusions. Activation of metabolic processes of the thyroid gland affects the universal protective systems of the body, which are especially pronounced under operational and perioperative stress by activating the redox system and depletion of antioxidant enzymes, which leads to the search for drugs to correct homeostasis.
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