RESULTS OF TREATMENT OF COMPLICATIONS OF DIABETIC FOOT SYNDROME WITH THE USE OF BIOBANDAGE
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.2.11271Keywords:
diabetic foot syndrome, bio bandage, phagocytosis, leukocytes, smears-imprintsAbstract
Summary. In 2017, the Center for Medical Statistics of the Ministry of Health of Ukraine recorded 2,757.7 million people with diabetes. However, due to latent forms of diabetes, the number of patients in Ukraine is 2–3 times higher than abovementioned. The wound process in patients with diabetic foot syndrome has its own peculiarities, so it requires the use of special dressings.
The aim of the study – to improve the results of treatment of complications of diabetic foot syndrome.
Materials and Methods. Analysis of the results of treatment of 29 patients with complicated forms of diabetic foot by conventional methods and 34 patients who underwent the use of biobandage. The control of the wound process was carried out by examining smears for the presence of the following elements: the number of leukocytes, the characteristics of phagocytosis, as well as other cellular elements of blood and connective tissue.
Results. In smears-imprints of both groups of patients the percentage of destruction of leukocytes decreased in time. On the 4th day, in the main group the indicator was 90.19 %, in the control group – 95.65 %; on the 8th day – 20.17 % and 33.89 %; on the 10th day – 1.5 % and 5.32 %, respectively. A significant decrease in the number of incomplete and degenerative types of phagocytosis in relation to the completed in the main group compared with the control was obtained on the 4th and 14th day of the wound process. Bacteriological examination yielded positive culture results and isolated 25 bacterial cultures. The rate of epithelialization in the main group was 4.4–4.6 % per day, compared with the control group, where it was 1.7–2.2 % per day.
Conclusions. Comparative evaluation of the results showed the effectiveness of the use of cultured tissue equivalents based on allofibroblasts, in the local treatment of complications of diabetic foot in comparison with traditional drugs.
References
Alekseev AA, Fystal NN, Podurets DP. [The effect of allofibroblast transplantation on the wound process and its outcomes in burned patients]. Kletochnye tekhnologii v biologii i meditsyne. 2010;1: 36-9. Russian.
Yarets YuI, Novykova IA, [Laboratory prognosis of the risk of autodermotransplant rejection]. Vestnik khirurgii. 2010;2: 34-8. Russian.
Myshalov VН, Kryvorchuk IH, Seliuk VM, Tesliuk II. [Cell and tissue transplantation in the complex treatment of patients with coronary heart disease]. Sertse i sudyny. 2004;1: 52-54. Ukrainian.
[Directory of the main indicators of the endocrinology service of Ukraine for 2015]. Endokrynolohiia. 2016;21(1): 40. Ukrainian.
Kolesnyk, YM, Ivanenko, TV, Abramov AV, Kuzo NV. [Current method soft hemodeling of experimental diabetes mellitus type 2: a literature review]. Patolohiia. 2016;1: 10-4. Ukrainian.
Slesarenko SV, Badiul PA, [The use of local flaps and the propeller technique for plastic restoration of integumentary tissue defects]. Khirurhiia Ukrainy. 2012;1(41): 103-12. Ukrainian.
Shkvarkovskyi IV, Antoniuk TV, Filipets OI, [The use of vacuum-cavitation rehabilitation methods in the treatment of diabetic syndrom]. 2014;1: 45-8. Ukrainian.
Anykyn AY, Horiunov SV, [Dermatoplastic interventions for diabetic foot syndrome]. Mizhnarodnyi endokrynolohichnyi zhurnal. 2009;5(23): 17-24. Ukrainian.
Vasyliuk SM, Krymets SA, [Surgical treatment of infected ulcers in patients with diabetic foot syndrome]. Ukrainskyi zhurnal khirurhii.2013;1(20): 20-24. Ukrainian.
Zaitseva EL, Tokmakova AYu, [The role of growth factors and cytokines in reparative processes in soft tissues in patients with diabetes mellitus].Tsukrovyi diabet. 2014;3: 57-62. Russian. DOI: https://doi.org/10.14341/DM2014157-62
