RELATIONSHIPS BETWEEN THE PARAMETERS OF JOINT PAIN AND EXCRETORY INSUFFICIENCY OF THE PANCREAS IN OSTEOARTHRITIS WITH COMORBID CONDITIONS
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.2.11265Keywords:
primary osteoarthritis, excretory insufficiency of the pancreas, clinical indices of joint pain, fecal α-elastaseAbstract
Summary. In recent years, it has been found that comorbid pathology significantly increases the level of disability and causes higher mortality in patients with osteoarthritis (OA). Lesions of the gastrointestinal tract (GIT), accompanied by a decrease in excretory function of the pancreas, are frequent pathological processes that accompany primary OA as comorbid conditions.
The aim of the study – to investigate the parameters of joint pain and their relationship with indicators of excretory function of the pancreas in patients with primary OA with comorbid conditions.
Materials and Methods. 132 outpatients with primary OA in combination with diseases associated with decreased excretory function of the pancreas were examined. The diagnosis of OA was established on the basis of diagnostic criteria of the ACR and the European League Against Rheumatism (EULAR). To assess the depth of the decrease in the secretory function of the pancreas, the level of fecal α-elastase was determined.
Results. There was a decrease in excretory function of the pancreas in patients with primary OA in the content of fecal α-elastase and coprogram score, which were statistically different for the control group (p<0,05). In patients with OA with comorbid conditions with excretory insufficiency, a statistically significant increase in the indices of VAS, Leken, WOMAC, a decrease in the Harris index relative to those in the control group (p <0.05). According to the rank indices of pain and the attitude of the McGill questionnaire, despite the chronic nature of pain, patients with primary OA in combination with a decrease in excretory function of the pancreas much attention paid to sensory features that are characteristic of emotionally stable individuals. The inverse correlations between the Leken index and the fecal α-elastase content, the Leken index and the coprogram score, as well as the high strength of the direct correlations between the Harris index and the fecal α-elastase content were also found.
Conclusions. The identified correlations proved the interdependence of the strength of the joint pain syndrome in primary OA and a decrease in the excretory function of the pancreas.
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