CHANGES OF LIPOPEROXIDATION INDICATORS IN EXPERIMENTAL PERIODONTITIS OF BACTERIAL-IMMUNE GENESIS AND EFFECT OF QUERCETIN ON THEM
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2020.2.11263Keywords:
periodontitis, inflammation, lipoperoxidation, diene conjugates, triene conjugates, flavonol, quercetinAbstract
Summary. Activation of lipid peroxidation and reduction of antioxidant activity disrupt the dynamic stability of erythrocyte membranes and contribute to the development of a pathological process in the periodontal complex. Multifactorial pathogenesis of generalized periodontitis involves adequate selection and prescription of drugs. Some flavonoids of plant origin, in particular quercetin, deserve special attention. Antioxidant activity of the drug is associated with its ability to inhibit lipid peroxidation, reduce the concentration of free radicals and toxic peroxidation products, stimulate catalase and superoxide dismutase activity of the organism.
The aim of the study – to determine the effect of flavonol quercetin on serum lipoperoxidation in experimental periodontitis of bacterial-immune genesis.
Materials and Methods. Biochemical studies of the activity of free radical processes in blood serum were performed, which were evaluated by the content of diene conjugates and triene conjugates on the 14th day of the study in the development of experimental periodontitis both before and after the use of water-soluble form of flavonol quercetin was administered to experimental animals intramuscularly at a dose of 100 mg/kg of animal weight for 7 days (from the 7th to the 14th day).
Results. This article covers the study of the peculiarities of lipoperoxidation processes in white rats in different periods of development of experimental periodontitis. In the process of forming an experimental bacterial-immune inflammatory process in the periodontal complex, which included the period from the 1st to the 14th day of experimental observation, there was an excessive accumulation in the serum of lipoperoxidation products, as evidenced by an increase in serum diene and triene conjugates. The use of the antioxidant flavonoid origin of quercetin led to a decrease in the content of lipoperoxidation products in the serum of animals.
Conclusions. In experimental periodontitis, products of lipid peroxidation accumulate, which affects the nature of the course and completion of the inflammatory process. A significant increase in the content of DC and TC indicates the role of the activity of free radical oxidation of lipids in the development of inflammation in the mechanisms of formation of its bacterial and immune components. Flavonol quercetin stabilizes the prooxidant system during experimental bacterial-immune periodontitis.
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