CELL IMMUNITY PECULIARITIES IN PRE- AND MENOPAUSAL WOMEN WITH HYPERPLASTIC ENDOMETRIAL PROCESSES
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2019.2.10626Keywords:
hyperplastic processes, endometrial hyperplasia, perimenopausal, cellular immunityAbstract
The aim of the work. To learn the indicators of cellular immunity in patients with endometrial hyperplastic processes.
Materials and Methods. We studied biopsy material and analyzed cellular immunity rates in 33 pre- and menopausal women, who were divided into three groups: group I consisted of 11 women with simple hyperplasia without atypia; group II – 2 women with simple atypical hyperplasia; group III – 20 women with complex hyperplasia without atypia. The control group consisted of 12 women without endometrial disease. A number of parameters were investigated: relative and absolute amounts of different subpopulations of peripheral blood lymphocytes, circulating immune complexes, basic functional indicators of phagocytic leukocytes in serum of venous blood.
Results and Discussion. In patients with endometrial hyperplastic processes, immunological homeostasis abnormalities manifested by T-lymphopenia, an imbalance in the subpopulation of T cells, mainly due to a decrease in circulating T-helper/inducers, leading to a decrease in CD4/CD8 factor and indicated the formation of secondary immunodeficiency. Individual analysis of the immunograms of patients with endometrial hyperplastic processes showed that in women with simple hyperplasia without atypia, the immunodeficiency was more often diagnosed by the hyposuppressive type, in patients with simple atypical hyperplasia showed immunosuppressive variant, and in women with complex endometrial hyperplasia, a predominantly proportional decrease in the CD4/CD8 immunoregulatory index was observed. Impaired local immunity function was found to be a significant decrease in phagocytic index in all women with hyperplastic endometrial processes and a decrease in proliferative activity of lymphocytes in women with simple endometrial hyperplasia without atypia and a tendency to increase it in patients with simple atypical endometrial hyperplasia.
Conclusions. The study of cellular immunity in patients with various types of endometrial hyperplasia revealed an increase in small circulating immune complexes in all patients and an increase in the concentration of medium circulating immune complexes in patients with simple hyperplasia without atypia and complex endometrial hyperplasia.
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Accepted 2019-12-18
Published 2020-01-31
