ATRIAL FIBRILLATION SCREENING, ITS CAUSAL MECHANISMS, ANALYSIS OF ETIOLOGICAL FACTORS AND TRIGGERS IN PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES MELLITUS

(LITERATURE REVIEW AND OWN OBSERVATIONS)

Authors

  • Yu. V. Honcharuk І. Horbachevsky Ternopil National Medical University
  • M. V. Hrebenyk І. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/bmbr.2706-6290.2020.4.11633

Keywords:

arterial hypertension, diabetes mellitus, atrial fibrillation

Abstract

Summary: Increases in blood pressure are registered in almost 25 % of the world's population. The prevalence of arterial hypertension (AH) increases significantly with age and in 50–60 years is 70 %. According to the WHO, 171 million (8.5 %) of the world's adult population have confirmed diabetes, and in 20 years the proportion of its detection is predicted to increase to 366 million or 114 %.  DM in patients with hypertension is 2–3 times more common than in people without hypertension. One of the most common complications of hypertension and diabetes is atrial fibrillation.

The aim of the study – to analyze the state of study and scientific achievements related to the prediction and course of AF in comorbid hypertension and diabetes and to conduct clinical and statistical comparisons with the data of their own observations.

Materials and Methods. Scientific sources for 20092018 were analyzed. 186 patients with hypertension and diabetes aged 20 to 74 years were examined.

Results.  According to the characteristics range of our results coincided with the literature. But, not all epidemiological studies gave a clear positive answer to the question of the independence of the causal nature of the relationship between hypertension, diabetes and the occurrence or deterioration of the prognosis of AF. Probably, the difference could be related to different research methodologies, including different characteristics of AF paroxysms, duration of diabetes, degree of glycemic control, etc.

Conclusions. Thus AF is a fairly common clinical syndrome, especially in conditions of comorbidity. Currently, the prevalence of hypertension in combination with diabetes is significant and is undoubtedly associated with the occurrence of AF. In this case, they together have a direct impact on the course of the underlying pathology and the course of the arrhythmic syndrome. Therefore, further careful study of the problem of the origin and development of AF in comorbid hypertension and diabetes becomes especially relevant.

References

Aleksandrov АА, Yadrykhynska MN, Kukharenko SS. Atrial fibrillation: a new facet of diabetes mellitus in the XXI century. Diabetes mellitus. 2011;(1): 53-9. Available from: https://doi.org/10.14341/2072-0351-6250.

Barsukov AV, Sveklyna TS, Talantseva MS., Shustov SB. Hypertension, type 2 diabetes mellitus, and atrial fibrillation as a separate medical problem. Arterial hypertension. 2011;17(2): 108-14. Available from: https://doi.org/10.18705/1607-419X-2011--2-.

Bevzyuk LV, Mudruk IV. 24-h blood pressure monitoring in elderly hypertensive patients with atrial fibrillation. Cardiology: from science to practice. 2017;(2): 19-28.

Eremenko EY, Ehorova EA, Sokolova LA. Hypertensive myocardial remodeling as a risk factor of atrial fibrillation in patients with arterial hypertension. Journal of Arrhythmology. 2011;(64): 38-43.

Sokolova YA, Bilovol OM, Ilchenko IA. The influence of myocardium remodeling on the emergence of arrhythmias in patients with hypertension and diabetes mellitus. Young Scientist. 2017;(9): 67-9.

Fushtei IM, Solovyev AV, Sid EV. [Analysis of heart rate variability in patients with persistent atrial fibrillation associated with arterial hypertension]. Zapor med zhurn. 2014;1(82): 64-5. Available from: https://doi.org/10.14739/2310-1210.2014.1.23769. Russian.

Shorikov EI. [The predictors of paroxysmal atrial fibrillation in patients with arterial hypertension and concomitant diabetes mellitus of type 2: results of long-term investigation]. Nauk. visn Uzhhorod univer. Ser «Med». 2013;(1): 60-5. Ukrainian.

Andrade J, Khairy P, Dobrev D, Nattel S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014;114: 1453-68. Available from: https://doi: 10.1161/CIRCRESAHA.114.303211.

Smith JG, Platonov PG, Hedblad B, Engström G, Melander O. Atrial fibrillation in the Malmö diet and cancer study: A study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol. 2010;(25): 95-102. Available from: https://doi:10.1007/s10654-009-9404-1.

Brandes A, Smit MD, Nguyen BO, Rienstra M, Van Gelder I. Risk factor management in atrial fibrillation. Arrhythmia & Electrophysiology Review. 2018;7(2): 118-27. Available from: https://doi: 10.1007/s10654-009-9404-1.

Koektuerk B, Aksoy M, Horlitz M, Bozdag-Turan I, Turan RG. Role of diabetes in heart rhythm disorders. World J. Diabetes. 2016;7(3): 45-9. Available from: https://doi: 10.4239/wjd.v7.i3.45.

Nattel S., Harada M. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives. J Am Coll Cardiol. 2014;63(22): 2335-45. Available from: https://doi: 10.1016/j.jacc.2014.02.555.

Salam АM, Gersh BJ, AlBinali HA, Singh R, Asaad N, Al-Qahtan A, et al. The prognostic implications of lack of palpitations in patients hospitalised with atrial fibrillation: observations from a 20-year registry. International J Clin Pract. 2014;68: 122-9. Available from: https://doi:10.1111/ijcp.12230.

Shkala LV, Mishanich GI, Shkala OV, Cherpak OV, Karapetyan EA, Volkovskaya TG. Pathogenetic mechanisms and signs of cardiovascular disorders in type 2 diabetes mellitus. Международный эндокринологический журнал. 2018;14(3): 235-9. Available from: https://doi.org/10.22141/2224-0721.14.3.2018.136418.

Szymanski FM, Filipiak KJ, Platek AE, Kotkowski M, Opolski G. Prevalence of arterial hypertension in patients with atrial fibrillation undergoing ablation. A prospective, cohort study. J of Hypertension. 2015;33;65. Available from: https://doi: 10.1097/01.hjh.0000467523.89875.59.

Published

2021-02-25

How to Cite

Honcharuk, Y. V., & Hrebenyk, M. V. (2021). ATRIAL FIBRILLATION SCREENING, ITS CAUSAL MECHANISMS, ANALYSIS OF ETIOLOGICAL FACTORS AND TRIGGERS IN PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES MELLITUS: (LITERATURE REVIEW AND OWN OBSERVATIONS). Bulletin of Medical and Biological Research, (4), 26–31. https://doi.org/10.11603/bmbr.2706-6290.2020.4.11633