Carbon nanotubes; their uses and health risks.
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i3.6953Keywords:
nanoparticles, carbon nanotubes, toxicityAbstract
The study analyzes the published literature data on key properties of one of the most important nanomaterials,carbon nanotubes. This material has a wide range of applications for biological and medical use. Among them there are visualization of molecular, cellular and tissue structures; construction of biosensors and electrodes; targeted delivery of various substances; and the use in radiation and photothermal therapies. It was demonstrated that depending on the route of administration and the dose, body carbon nanotubes are can be harmful to human body. At the same time, increasing use of this material suggests that further research of its characteristics and their impact on human health is needed.
References
Durnev, A. D. (2008). Toksykolohyia nanochastyts. Biull. Eksperym. byolohyy y medytsyny, 145 (1), 72–74.
Zahorodnii, I. V., Dmukhovska, T. M., Sydorenko, M. O., & Semenova, N. V. (2013). Problemy hihiieny pratsi ta bezpeky u vyrobnytstvi ta vykorystanni nanochastynok i nanotekhnolohii. Medytsyna sohodni i zavtra, 3 (60), 52–56.
Mykytiuk, M. V. (2011). Nanochastynky ta perspektyvy yikh zastosuvannia v biolohii i medytsyni. Problemy ekolohii ta medytsyny, 15 (5–6), 41–49.
Mytrofanova, Y. V., Mylto, Y. V., Sukhodolo, Y. V., & Vasiukov, H. Yu. (2014) Vozmozhnosty byomedytsynskoho prymenenyia uhlerodnykh nanotrubok. Biull. sybyrskoi medytsyny,13(1), 135–144.
Moskalenko, V. F., & Yavorovskyi, O. P. (2009). Ekolohichni i toksykoloho-hihiienichni aspekty biolohichnoi bezpeky nanotekhnolohii, nanochastynok ta nanomaterialiv. Nauk. visn. Nats. med. un-tu im. O. O. Bohomoltsia, 3, 25–35.
Moskalenko, V. F., Lisovyi, V. M., & Chekman, I. S. (2009). Naukovi osnovy nanomedytsyny, nanofarmakolohii ta nanofarmatsii. Nauk. visn. Nats. med. un-tu im. O. O. Bohomoltsia, 2, 17–31.
Lakhtyn, V. M., Afanasev, S. S., & Lakhtyn, M. V. (2008). Nanotekhnolohyy y perspektyvy ykh yspolzovanyia v medytsyne y byotekhnolohyy. Vestn. RAMN, 4, 50–55.
Moskalenko, V. F., Rozenfeld, L. H., Movchan, B. O., & Chekman, I. S. (2008). Nanotekhnolohii, nanomedytsyna, nanofarmakolohiia: stan, perspektyvy naukovykh doslidzhen, vprovadzhennia v medychnu praktyku. Chelovek y lekarstvo. Ukrayna. materyaly I nats. konhr. K, 167–168.
Prylutska, S. V., Remeniak, O. V., & Honcharenko, Yu. V. (2009). Vuhletsevi nanotrubky yak novyi klas materialiv dlia bionanotekhnolohii. Biotekhnolohiia, 2, 13–24.
Radylov, A. S. (2008). Obespechenye bezopasnosty razrabotky nanotekhnolohyi, oborota nanomateryalov y produktsyy na ykh osnove. dokl. na II Mezhdunar. forume po nanotekhnolohyiam, Rusnanotech. SPb, 34.
Rotko, D. M., Prylutska, S. V., Bohutska, K. I., & Prylutskyi, Yu. I. (2011). Vuhletsevi nanotrubky yak novitni materialy dlia neiroinzhenerii. Biotekhnolohiia, 4, 9–24.
Telehieieva, P. H., Yefremenko, D. S., Telehieiev, H. D., & Maliuta, S. S. (2013). Zastosuvannia nanochastynok u biomedytsyni. Biotekhnolohiia, 6 (2), 21–32.
Chekman, I. S., Serdiuk, A. M., & Kundiiev, Yu. I. (2009). Nanotoksykolohiia: napriamky doslidzhen. Dovkillia ta zdorovia, 1 (48), 3–7.
Chekman, I. S., Horchakova, N. O., Nahorna, O. O., & Nahorna, T. I. (2010). Nanochastynky: vprovadzhennia u medychnu praktyku. Visn. farmakolohii ta farmatsii, 10, 2–11.
Shatorna, V. F. (2013). Nanotekhnolohii, nanomedytsyna, nanobiolohiia:pohliad na problem. Visn. problem biolohii i medytsyny, 2 (99), vyp. 1, 40–44.
Bhirde, A. A., Patel, V., & Gavard, J. (2009). Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano, 2 (3), 307–316.
Carbon nanotubes in cancer theragnosis (2010). Nanomedecine, 5, 1277–1301.
Cheng, S. H. (2011). Toxicology and Applied Pharmacology, 250, 184–193.
Risom, L., Jacobsen, N., & Wallin, H. (2009). Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environmental Health Perspectives, 117 (5), 1557–1566.
Ji, S., Liu, C., Zhang, B., & Yang, F. (2010). Carbon nanotubes in cancer diagnosis and therapy. Biochimica et Biophysica Acta, 1806, 1121–112.
Kateb, B., Yamamoto, V., & Alizadeh, D. (2010). Multi-walled carbon nanotube (MWCNT) synthesis, preperetion, labeling, and functionalization. Immunotherapy of Cancer, Methods in Molecular Biology, 651, 307–317.
Liu, Z., Fan, A. C., & Rakhra, K. (2009). Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy, Angew. Chem. Int. Ed Engl, 41 (48), 7668–7672.
Mahmood, M. (2010). Cytotoxicity and biological effects of functional nanomaterials delivered to various cell lines. J. Appl. Toxicol, 30, 74–83.
Mahmood, M., Karmakar, A., & Fejleh, A. (2009). Synergistic enhancement of cancer therapy using a combination of carbon nanotubes and antitumor drug. Nanomedicine. (London), 4, 883–893.
Mercer, R. R., Scabilloni, J., & Wang, L. (2008). Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am. J. Physiol. Lung. Cell. Mol. Physiol, 294, 87–97.
Reilly, R. M. (2007). Carbon nanotubes: potential benefits and risks of nanotechnology in nuclear medicine. The J. of Nuclear Medicine, 48 (7), 1039–1042.
Shvedova, A. A., Kisin, E. R., & Porter, P. (2009). Mechanism of pulmonary toxicity and medical applications of carbon nanotubes: two faces of Janus. Pharmacology & Therapeutics, 121, 192–204.
Subbiah, R. P., Veerapandian, M., Sadhasivam, S., & Yun, K. (2011). Structural and biological evaluation of a multifunctional SWCNT-AgNPs-DNA/PVA bio-nanofilm. Electronic supplementary material, 4, 547–560.
Tsuda, H., Xu, J., & Sakai, Y. (2009). Toxicology of engineered nanomaterials – a review of carcinogenic potential. Asian Pacific Journal of Cancer Prevention, 10, 975–980.
Yamashita, K. (2010). Carbon nanotubes elicit DNA damage and in-flammatory response relative to their size and shape. In-flammation, 33 (4), 276–280.
